Výsledky vyhledávání - "Petäjä-Repo U"

GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin

Autor: Mattila, S. O. (S. Orvokki), Tuhkanen, H. E. (Hanna E.), Lackman, J. J. (Jarkko J.), Konzack, A. (Anja), Morató, X. (Xavier), Argerich, J. (Josep), Saftig, P. (Paul), Ciruela, F. (Francisco), Petäjä-Repo, U. E. (Ulla E.)

GPR37 is an orphan G protein-coupled receptor (GPCR) implicated in several neurological diseases and important physiological pathways in the brain. We previously reported that its long N-terminal ectodomain undergoes constitutive metalloprotease-medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::5beb7ea88f417fc3dbda14a0551a1e40
http://urn.fi/urn:nbn:fi-fe2021060132573

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G protein-coupled receptors in the sweet spot:glycosylation and other post-translational modifications

Autor: Goth, C. K. (Christoffer K.), Petäjä-Repo, U. E. (Ulla E.), Rosenkilde, M. M. (Mette M.)

Post-translational modifications (PTMs) are a fundamental phenomenon across all classes of life and several hundred different types have been identified. PTMs contribute widely to the biological functions of proteins and greatly increase their divers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::d76862656df0dadb48f8d8f2d12e376b
http://urn.fi/urn:nbn:fi-fe2020042119535

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The Parkinson’s-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding

Autor: Mattila, S. O. (S. Orvokki), Tuusa, J. T. (Jussi T.), Petäjä-Repo, U. E. (Ulla E.)

The G-protein-coupled receptor 37 ( GPR37) has been implicated in the juvenile form of Parkinson’s disease, in dopamine signalling and in the survival of dopaminergic cells in animal models. The structure and function of the receptor, however, have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::be1ec99102bcfe46117bef80f9fe789d
http://urn.fi/urn:nbn:fi-fe2019120345449

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N-glycan-dependent and -independent quality control of human δ opioid receptor N-terminal variants

Autor: Lackman, J. J. (Jarkko J.), Markkanen, P. M. (Piia M. H.), Hogue, M. (Mireille), Bouvier, M. (Michel), Petäjä-Repo, U. E. (Ulla E.)

Quality control (QC) in the endoplasmic reticulum (ER) scrutinizes newly synthesized proteins and directs them either to ER export or ER-associated degradation (ERAD). Here, we demonstrate that the human δ-opioid receptor (hδOR) is subjected to ERQ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::32834bc81cf4492540073f2df4a773c7
http://urn.fi/urn:nbn:fi-fe2019120545771

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Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization

Autor: Leskelä, T. T. (Tarja T.), Lackman, J. J. (Jarkko J.), Vierimaa, M. M. (Miia M.), Kobayashi, H. (Hiroyuki), Bouvier, M. (Michel), Petäjä-Repo, U. E. (Ulla E.)

The important role of G protein-coupled receptor homo/heteromerization in receptor folding, maturation, trafficking, and cell surface expression has become increasingly evident. Here we investigated whether the human δ-opioid receptor (hδOR) Cys-27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::f70d062e70fc11dfbaff3ec9dff46697
http://urn.fi/urn:nbn:fi-fe2019120445647

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Human β1-adrenergic receptor is subject to constitutive and regulated N-terminal cleavage

Autor: Hakalahti, A. E. (Anna E.), Vierimaa, M. M. (Miia M.), Lilja, M. K. (Minna K.), Kumpula, E.-P. (Esa-Pekka), Tuusa, J. T. (Jussi T.), Petäjä-Repo, U. E. (Ulla E.)

The β₁-adrenergic receptor (β₁AR) is the predominant βAR in the heart, mediating the catecholamine-stimulated increase in cardiac rate and force of contraction. Regulation of this important G protein-coupled receptor is nevertheless poorly und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::6793a59806b30d904f8b64f69b6d4950
http://urn.fi/urn:nbn:fi-fe2019120445642

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N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded alfa-opioid receptors at the cell surface

Autor: Markkanen, P. M. (Piia M. H.), Petäjä-Repo, U. E. (Ulla E.)

A great majority of G protein-coupled receptors are modified by N-glycosylation, but the functional significance of this modification for receptor folding and intracellular transport has remained elusive. Here we studied these phenomena by mutating t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::ee7da05c707db6e24607d8b8e1565216
http://urn.fi/urn:nbn:fi-fe2019121948904

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Opioid receptor pharmacological chaperones act by binding and stabilizing newly synthesized receptors in the endoplasmic reticulum

Autor: Leskelä, T. T. (Tarja T.), Markkanen, P. M. (Piia M. H.), Pietilä, E. M. (E. Maritta), Tuusa, J. T. (Jussi T.), Petäjä-Repo, U. E. (Ulla E.)

Accumulating evidence has indicated that membrane-permeable G protein-coupled receptor ligands can enhance cell surface targeting of their cognate wild-type and mutant receptors. This pharmacological chaperoning was thought to result from ligand-medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::b3b00b4c27eda4113c17bb10954e7106
http://urn.fi/urn:nbn:fi-fe2019121948927

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