Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

Autor: Vuorela, A., Freitag, T. L., Leskinen, K., Pessa, H., Härkönen, T., Stracenski, I., Kirjavainen, T., Olsen, P., Saarenpää-Heikkilä, O., Ilonen, J., Knip, M., Vaheri, A., Partinen, M., Saavalainen, P., Meri, S., Vaarala, O.

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Narcolepsy type 1 (NT1) is a chronic neurological disorder having a strong association with HLA-DQB1*0602, thereby suggesting an immunological origin. Increased risk of NT1 has been reported among children or adolescents vaccinated with AS03 adjuvant

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https://trepo.tuni.fi/handle/10024/132381

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Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.

Autor: Vuorela A; Clinicum, University of Helsinki, Helsinki, Finland., Freitag TL; Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. tobias.freitag@helsinki.fi.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland. tobias.freitag@helsinki.fi., Leskinen K; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Pessa H; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Härkönen T; Clinicum, University of Helsinki, Helsinki, Finland., Stracenski I; Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland., Kirjavainen T; Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland., Olsen P; Department of Child Neurology, Oulu University Hospital, Oulu, Finland., Saarenpää-Heikkilä O; Department of Pediatrics, Tampere University Hospital, Tampere, Finland., Ilonen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland., Knip M; Clinicum, University of Helsinki, Helsinki, Finland.; Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Vaheri A; Department of Virology, University of Helsinki, Helsinki, Finland., Partinen M; Clinicum, University of Helsinki, Helsinki, Finland.; Department of Neurosciences, University of Helsinki, Helsinki, Finland.; Helsinki Sleep Clinic, Vitalmed Research Center, Helsinki, Finland., Saavalainen P; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Meri S; Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Vaarala O; Clinicum, University of Helsinki, Helsinki, Finland.

Publikováno v: Nature communications [Nat Commun] 2021 Apr 16; Vol. 12 (1), pp. 2283. Date of Electronic Publication: 2021 Apr 16.