Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

Autor: Cristiano Scottà, Marianna Esposito, Henrieta Fazekasova, Giorgia Fanelli, Francis C. Edozie, Niwa Ali, Fang Xiao, Mark Peakman, Behdad Afzali, Pervinder Sagoo, Robert I. Lechler, Giovanna Lombardi

Publikováno v: Haematologica, Vol 98, Iss 8 (2013)

Adoptive transfer of ex vivo expanded CD4+CD25+FOXP3+ regulatory T cells is a successful therapy for autoimmune diseases and transplant rejection in experimental models. In man, equivalent manipulations in bone marrow transplant recipients appear saf

Externí odkaz: https://doaj.org/article/ed6bd5a55ae64dfe92fe7066766dc3c7

The transformative potential of HSC gene therapy as a genetic medicine

Autor: Pervinder Sagoo, H. Bobby Gaspar

Publikováno v: Gene Therapy. 30:197-215

Hematopoietic stem cells (HSCs) are precursor cells that give rise to blood, immune and tissue-resident progeny in humans. Their position at the starting point of hematopoiesis offers a unique therapeutic opportunity to treat certain hematologic dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb8ee9a1d9c1c7ffbaba3e539345e9a1
https://doi.org/10.1038/s41434-021-00261-x

Monitoring the efficacy of dendritic cell vaccination by early detection of 99mTc-HMPAO-labelled CD4+ T cells

Autor: Robert I. Lechler, Lesley A. Smyth, John Leech, Pervinder Sagoo, Giovanna Lombardi, Niwa Ali, Ehsan Sharif-Paghaleh, Kavitha Sunassee, Gregory E. D. Mullen

Publikováno v: European Journal of Immunology

DC vaccines have been used to induce tumour-specific cytotoxic T cells . However, this approach to cancer immunotherapy has had limited success. To be successful, injected DCs need to migrate to the LNs where they can stimulate effector T cells . We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c187e5c9b28fa947684d221a4a27d71a
http://europepmc.org/articles/PMC4211358

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

Autor: Béatrice Breart, Susanna Celli, David Michonneau, Pervinder Sagoo, Zacarias Garcia, Philippe Bousso

Publikováno v: Immunity
Immunity, 2016, CellPress, 44 (1), p143-154. ⟨10.1016/j.immuni.2015.12.008⟩
Immunity, Elsevier, 2016, CellPress, 44 (1), p143-154. ⟨10.1016/j.immuni.2015.12.008⟩

International audience; Allogeneic hematopoietic stem cell transplantation (allo-HSCT), a curative treatment for hematologic malignancies relies on donor cytotoxic T lymphocyte (CTL)-mediated graft-versus-leukemia (GVL) effect. Major complications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb94e9b006dd5ed6d23bf3f2ddca851e
https://hal-pasteur.archives-ouvertes.fr/pasteur-01296510/document

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

Autor: Béatrice Breart, Matthew L. Albert, Fabrice Lemaître, David Michonneau, Philippe Bousso, Zacarias Garcia, Pervinder Sagoo, Yves Levy

Publikováno v: Nature Medicine
Nature Medicine, 2015, 22 (1), pp.64-71. ⟨10.1038/nm.4016⟩
Nature Medicine, Nature Publishing Group, 2015, 22 (1), pp.64-71. ⟨10.1038/nm.4016⟩

International audience; The inflammasome is activated in response to a variety of pathogens and has an important role in shaping adaptive immunity, yet the spatiotemporal orchestration of inflammasome activation in vivo and the mechanisms by which it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbdd67e421ab9ac25057d9b23f2367c
https://hal-pasteur.archives-ouvertes.fr/pasteur-01253201/file/BoussoNatMed2015.pdf