Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Perttu, Permi"'
Autor:
Lina Antenucci, Salla Virtanen, Chandan Thapa, Minne Jartti, Ilona Pitkänen, Helena Tossavainen, Perttu Permi
Publikováno v:
eLife, Vol 13 (2024)
Orchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of
Externí odkaz:
https://doaj.org/article/b157d9722e894309b11a1b24ac6a49b2
Autor:
Jukka E. Hintikka, Juha P. Ahtiainen, Perttu Permi, Sirpa Jalkanen, Marko Lehtonen, Satu Pekkala
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Physical activity is essential in weight management, improves overall health, and mitigates obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual exercise may improve gut’s microbial diversity and increase
Externí odkaz:
https://doaj.org/article/9e07fcef98e841a3842c9fc70d66c8a0
Autor:
Annsy Arredondo-Nuñez, Gisele Monteiro, Carol N. Flores-Fernández, Lina Antenucci, Perttu Permi, Amparo Iris Zavaleta
Publikováno v:
Life, Vol 13, Iss 11, p 2145 (2023)
L-asparaginases from bacterial sources have been used in antineoplastic treatments and the food industry. A type II L-asparaginase encoded by the N-truncated gene ansZP21 of halotolerant Bacillus subtilis CH11 isolated from Chilca salterns in Peru wa
Externí odkaz:
https://doaj.org/article/eb996385304f4acd8144c151d7879083
Autor:
Terhi Maula, Nelli Vahvelainen, Helena Tossavainen, Tuuli Koivunen, Marja T. Pöllänen, Anders Johansson, Perttu Permi, Riikka Ihalin
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 1239-1257 (2021)
Late embryogenesis abundant (LEA) proteins are important players in the management of responses to stressful conditions, such as drought, high salinity, and changes in temperature. Many LEA proteins do not have defined three-dimensional structures, s
Externí odkaz:
https://doaj.org/article/550f4ceee2c0421892f94678d1e2a434
Autor:
Ayman Khattab, Mikel Rezola, Marta Barroso, Mikael Kyrklund, Tero Pihlajamaa, Tobias L. Freitag, Geert-Jan van Gemert, Teun Bousema, Perttu Permi, Ossi Turunen, Robert Sauerwein, Adrian J. F. Luty, Seppo Meri
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces. Here, we report hijacking of the c
Externí odkaz:
https://doaj.org/article/f2b7bff8992c46d0b53b8fb320cfed0c
Autor:
Zhe Zhao, Riku Fagerlund, Helena Tossavainen, Kristina Hopfensperger, Rishikesh Lotke, Smitha Srinivasachar Badarinarayan, Frank Kirchhoff, Perttu Permi, Kei Sato, Daniel Sauter, Kalle Saksela
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1009728 (2021)
The accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is req
Externí odkaz:
https://doaj.org/article/1318f37ecbe84d2aabcfcf4234f5b6b8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has
Externí odkaz:
https://doaj.org/article/ce6b1deaeab1492aac1d0666019f2b51
Autor:
Sira Karvinen, Vasco Fachada, Ulla-Maria Sahinaho, Satu Pekkala, Juulia H. Lautaoja, Sakari Mäntyselkä, Perttu Permi, Juha J. Hulmi, Mika Silvennoinen, Heikki Kainulainen
Publikováno v:
Metabolites, Vol 12, Iss 4, p 328 (2022)
Impaired lipid metabolism is a common risk factor underlying several metabolic diseases such as metabolic syndrome and type 2 diabetes. Branched-chain amino acids (BCAAs) that include valine, leucine and isoleucine have been proven to share a role in
Externí odkaz:
https://doaj.org/article/9563f74eb14d4375a9cb8b2316539114
Autor:
Maria Kaukonen, Sean Woods, Saija Ahonen, Seppo Lemberg, Maarit Hellman, Marjo K. Hytönen, Perttu Permi, Tom Glaser, Hannes Lohi
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2643-2652 (2018)
Maternally skewed transmission of traits has been associated with genomic imprinting and oocyte-derived mRNA. We report canine congenital eye malformations, caused by an amino acid deletion (K12del) near the N terminus of retinol-binding protein (RBP
Externí odkaz:
https://doaj.org/article/19030cb9d7154372b571c14092bec77c
Autor:
Vytas Raulinaitis, Helena Tossavainen, Olli Aitio, Jarmo T. Juuti, Keiichi Hiramatsu, Vesa Kontinen, Perttu Permi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract We introduce LytU, a short member of the lysostaphin family of zinc-dependent pentaglycine endopeptidases. It is a potential antimicrobial agent for S. aureus infections and its gene transcription is highly upregulated upon antibiotic treatm
Externí odkaz:
https://doaj.org/article/c8e8573d85a24ba684ea4c55fbb932a8