Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Pertti Kaihovaara"'
Autor:
Ryuhei Maejima, Katsunori Iijima, Pertti Kaihovaara, Waku Hatta, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa, Mikko Salaspuro
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120397 (2015)
Acetaldehyde (ACH) associated with alcoholic beverages is Group 1 carcinogen to humans (IARC/WHO). Aldehyde dehydrogenase (ALDH2), a major ACH eliminating enzyme, is genetically deficient in 30-50% of Eastern Asians. In alcohol drinkers, ALDH2-defici
Externí odkaz:
https://doaj.org/article/7f98145d7dc04a5abe35b2652d0d0153
Autor:
Ioannis Dragatsis, Pradeep K. Shukla, Paula Dietrich, Toyohi Isse, Bhargavi Manda, Laura E. Nagy, Ruchika Gangwar, Radhakrishna Rao, Geetha Samak, Mikko Salaspuro, Kamaljit K. Chaudhry, Pertti Kaihovaara, Toshihiro Kawamoto, Hina Mir
Publikováno v:
Alcoholism: Clinical and Experimental Research. 39:1465-1475
Background Acetaldehyde, the toxic ethanol (EtOH) metabolite, disrupts intestinal epithelial barrier function. Aldehyde dehydrogenase (ALDH) detoxifies acetaldehyde into acetate. Subpopulations of Asians and Native Americans show polymorphism with lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84d73bfaee95e947155a736387bfb6b
https://doi.org/10.1111/acer.12777
https://doi.org/10.1111/acer.12777
Autor:
Dominic-Luc Webb, Lea Paloheimo, Axel Meierjohann, Leif Kronberg, Kari Syrjänen, Panu Hendolin, Per M. Hellström, Heidi Sundelin, Anders Millerhovf, Mikko Salaspuro, Pertti Kaihovaara
Introduction: Helicobacter-induced atrophic gastritis with a hypochlorhydric milieu is a risk factor for gastric cancer. Microbes colonising acid-free stomach oxidise ethanol to acetaldehyde, a recognised group 1 carcinogen. Objective: To assess gast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8d60672a6f30f1f0c65ea1043f7133
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316135
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316135
Autor:
Johanna Kurkivuori, Kirsti Kari, Pertti Kaihovaara, Jukka H. Meurman, Lisa Grönroos, Mikko Salaspuro, Ville Salaspuro, Riina Rautemaa
Publikováno v:
Oral Oncology. 43:181-186
Alcohol is a well documented risk factor for upper digestive tract cancers. It has been shown that acetaldehyde, the first metabolite of ethanol is carcinogenic. The role of microbes in the production of acetaldehyde to the oral cavity has previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ddb9d8b293d738f20e0bf405b8ece8
https://doi.org/10.1016/j.oraloncology.2006.02.005
https://doi.org/10.1016/j.oraloncology.2006.02.005
Publikováno v:
Annals of Pharmacotherapy. 36:971-974
BACKGROUND: Metronidazole, an effective antianaerobic agent, has been reported to have aversive properties when ingested with ethanol. This is thought to be due to the blocking of hepatic aldehyde dehydrogenase (ALDH) enzyme followed by the accumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd07e99739eb79ec2a31199b3c4d7ed
https://doi.org/10.1345/aph.1a066
https://doi.org/10.1345/aph.1a066
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:1113-1119
Ingested ethanol is transported to the colon via blood circulation, and intracolonic ethanol levels are equal to those of the blood ethanol levels. In the large intestine, ethanol is oxidized by colonic bacteria, and this can lead to extraordinarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a8a9fd96139b5a7cf64d24044a9277
https://doi.org/10.1111/j.1530-0277.1998.tb03709.x
https://doi.org/10.1111/j.1530-0277.1998.tb03709.x
Publikováno v:
Journal of Antimicrobial Chemotherapy. 41:171-177
Helicobacter pylori flavodoxin was purified to homogeneity from cell extracts of strain NCTC 11637. The molecular weight of the protein was estimated by gel electrophoresis to be 18 kDa. Oxidized flavodoxin showed an absorption spectrum with maxima a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee913a045cf55141acc0e9a2e6c72cc
https://doi.org/10.1093/jac/41.2.171
https://doi.org/10.1093/jac/41.2.171
Autor:
Riina Rautemaa, Malcolm Richardson, Emilia Marttila, Pertti Kaihovaara, Dominique Sanglard, Paul Bowyer, Mikko Salaspuro, Johanna Uittamo
Publikováno v:
Molecular oral microbiology. 28(4)
Acetaldehyde is a carcinogenic product of alcohol fermentation and metabolism in microbes associated with cancers of the upper digestive tract. In yeast acetaldehyde is a by-product of the pyruvate bypass that converts pyruvate into acetyl-Coenzyme A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac30bc96af542641ba71bb7f961f504
https://pubmed.ncbi.nlm.nih.gov/23445445
https://pubmed.ncbi.nlm.nih.gov/23445445
Publikováno v:
Alcoholism: Clinical and Experimental Research. 20:1011-1015
To evaluate the possible role of catalase in gastric ethanol metabolism in rats, we studied acetaldehyde formation from ethanol by gastric mucosal homogenate under various in vitro conditions. Homogenized rat gastric mucosa produced significant amoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a4c7b97be85b833ffef9ebab65f2fa
https://doi.org/10.1111/j.1530-0277.1996.tb01939.x
https://doi.org/10.1111/j.1530-0277.1996.tb01939.x
Autor:
Peter Rudnai, Tamás Pándics, Dana Mates, Pertti Kaihovaara, Jolanta Lissowska, Ariana Znaor, Mikko Salaspuro, Beata Swiatkowska, Paolo Boffetta
Intake of acetaldehyde in alcoholic beverages, in Central Europe, might explain the high rate of alcohol-related diseases in these countries. We measured the acetaldehyde level in 30 samples of home-made spirits and 12 samples of industry-made spirit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442ab2c3812863477cdffeeea8fd3615
https://www.bib.irb.hr/563107
https://www.bib.irb.hr/563107