Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Perspectives - Minireview"'
Autor:
Young-Joon Surh, Jiyoung Kim
Publikováno v:
Toxicological Research
Nuclear factor erythroid derived 2-related factor-2 (Nrf2) is a master transcription regulator of antioxidant and cytoprotective proteins that mediate cellular defense against oxidative and inflammatory stresses. Disruption of cellular stress respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49391c26007656925b4b084f350a2a4f
https://doi.org/10.5487/tr.2009.25.4.159
https://doi.org/10.5487/tr.2009.25.4.159
Autor:
Byung Mu Lee, Kyu-Bong Kim
Publikováno v:
Toxicological Research
Metabolomics which deals with the biological metabolite profile produced in the body and its relation to disease state is a relatively recent research area for drug discovery and biological sciences including toxicology and pharmacology. Metabolomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608d2c998048a147c9d5c4fdf5d8d0cb
http://europepmc.org/articles/PMC7006259
http://europepmc.org/articles/PMC7006259
Publikováno v:
Toxicological Research
Validation specifies and coordinates all relevant activities to ensure compliance with good laboratory practices (GLP) according to suitable international standards. This includes validation activities of past, present and future for the best possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49187cfcb5a3071561ebbec74569650b
http://europepmc.org/articles/PMC7006250
http://europepmc.org/articles/PMC7006250
Autor:
Jinhee Choi
Publikováno v:
Toxicological Research
While in some instances, loss of diversity results from acute toxicity (e.g. major pollution incidents), in most cases it results from long-term sub-lethal effects that alter the relative competitive ability and fitness of certain organisms. In such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3909958f19a09a4d789840635a9e38f
https://doi.org/10.5487/tr.2008.24.4.235
https://doi.org/10.5487/tr.2008.24.4.235
Publikováno v:
Toxicological Research
Recently, arsenic-toxicity has become the major focus of strenuous assessment and dynamic research from the academy and regulatory agency. To elucidate the cause and the mechanism underlying the serious adverse health effects from chronic ingestion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8bd96eb8c9c60ed9c266e45f95c265
https://doi.org/10.5487/tr.2008.24.3.161
https://doi.org/10.5487/tr.2008.24.3.161
Autor:
Sun-Young Han
Publikováno v:
Toxicological Research
Targeting protein kinases has been active area in drug discovery. The c-Jun N-terminal kinases (JNKs) have also been target for development of novel therapy in various diseases, since the roles of JNK signaling in pathological conditions were reveale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62fdde7230c0072758c1322a7888818
https://doi.org/10.5487/tr.2008.24.2.093
https://doi.org/10.5487/tr.2008.24.2.093
Autor:
Hyunsung Park
Publikováno v:
Toxicological Research
Studies on hypoxia-signaling pathways have revealed novel Fe(II) and α-ketoglutarate-dependent dioxygenases that hydroxylate prolyl or asparaginyl residues of a transactivator, Hypoxia-Inducible Factor-α (HIF-α) protein. The recognition of these u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c046e00afee87362231d777929d0e19f
https://pubmed.ncbi.nlm.nih.gov/32038783
https://pubmed.ncbi.nlm.nih.gov/32038783