Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Perspective Series"'
Publikováno v:
Journal of Clinical Investigation. 113:169-174
Damage to DNA, the prime target of anticancer therapy, triggers programmed cellular responses. In addition to apoptosis, therapy-mediated premature senescence has been identified as another drug-responsive program that impacts the outcome of cancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6065efbc1547243f22437b157d6c6456
https://doi.org/10.1172/jci20784
https://doi.org/10.1172/jci20784
Autor:
Ronald A. DePinho, Norman E. Sharpless
Publikováno v:
Journal of Clinical Investigation. 113:160-168
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(IN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7b0fb6fd3b236f5ed565e395a9287f
https://doi.org/10.1172/jci20761
https://doi.org/10.1172/jci20761
Autor:
Ittai, Ben-Porath, Robert A, Weinberg
Publikováno v:
Journal of Clinical Investigation. 113:8-13
Cells entering a state of senescence undergo a permanent cell cycle arrest, accompanied by a set of functional and morphological changes. Senescence of cells occurs following an extended period of proliferation in culture or in response to various ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80eb6d8b42d778e4a105dbc9a536c10
https://doi.org/10.1172/jci200420663
https://doi.org/10.1172/jci200420663
Autor:
Pelicci, Pier Giuseppe
Publikováno v:
Journal of Clinical Investigation. 113:4-7
Stem/progenitor cells ensure tissue and organism homeostasis and might represent a frequent target of transformation. Although these cells are potentially immortal, their life span is restrained by signaling pathways (p19-p53; p16-Rb) that are activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f11f15b34523db081104410b2d3210
https://doi.org/10.1172/jci200420750
https://doi.org/10.1172/jci200420750
Autor:
Roger S, Smith, Barbara H, Iglewski
Publikováno v:
Journal of Clinical Investigation. 112:1460-1465
Pseudomonas aeruginosa has two complete quorum-sensing systems. Both of these systems have been shown to be important for Pseudomonas virulence in multiple models of infection. Thus, these systems provide unique targets for novel antimicrobial drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4795117d8174f6df1fd013c7e85f103f
https://doi.org/10.1172/jci200320364
https://doi.org/10.1172/jci200320364
Autor:
William Costerton, Richard Veeh, Mark Shirtliff, Mark Pasmore, Christopher Post, Garth Ehrlich
Publikováno v:
Journal of Clinical Investigation. 112:1466-1477
Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d02a69294ac788cdbaf155150cbf92
https://doi.org/10.1172/jci200320365
https://doi.org/10.1172/jci200320365
Autor:
Michael Givskov, Morten Hentzer
Publikováno v:
Journal of Clinical Investigation. 112:1300-1307
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb753a1e4f4448ba25b607a0fb9b94c4
https://doi.org/10.1172/jci20074
https://doi.org/10.1172/jci20074
Publikováno v:
Journal of Clinical Investigation. 112:312-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630274d35ca1d2e840076e75099a730d
https://doi.org/10.1172/jci200319386
https://doi.org/10.1172/jci200319386
Autor:
Eamonn R. Maher, Wolf Reik
Publikováno v:
Journal of Clinical Investigation. 105:247-845
Genomic imprinting, a process that causes genes to be expressed according to their parental origin, affects a minority of human genes, probably less than 1,000. Nevertheless, this class of epigenetic modification acts on many genes with critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96d1ba2a72d69a7db90e909025e1e76
https://doi.org/10.1172/jci9340
https://doi.org/10.1172/jci9340
Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6697787168de2f2c94d6ff947ec220f
https://europepmc.org/articles/PMC311443/
https://europepmc.org/articles/PMC311443/
