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Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

Autor: Personne, Hippolyte, Siriwardena, Thissa N, Javor, Sacha, Reymond, Jean-Louis

Publikováno v: Personne, Hippolyte; Siriwardena, Thissa N; Javor, Sacha; Reymond, Jean-Louis (2023). Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis. ACS Omega, 8(5), pp. 5050-5056. American Chemical Society 10.1021/acsomega.2c07861

Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to strongly reduce aspartimide formation compared to piperidine (PPR) in high-temperature (60 °C) solid-phase peptide synthesis (SPPS). In contrast to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94bab1e38c6a5076b69bc6fdcf0cbca
https://doi.org/10.1021/acsomega.2c07861

To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide

Autor: Personne, Hippolyte, Paschoud, Thierry, Fulgencio, Sofia, Baeriswyl, Stéphane, Köhler, Thilo, van Delden, Christian, Stocker, Achim, Javor, Sacha, Reymond, Jean-Louis

Publikováno v: Personne, Hippolyte; Paschoud, Thierry; Fulgencio, Sofia; Baeriswyl, Stéphane; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2023). To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide. Journal of medicinal chemistry, 66(11), pp. 7570-7583. American Chemical Society 10.1021/acs.jmedchem.3c00460

Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address multidrug resistance; however, most AMPs are toxic and unstable in serum. These limitations can be partly overcome by introducing D-residues, which often con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cd560f00f640a411ea1d9947da5764
https://doi.org/10.1021/acs.jmedchem.3c00460

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Conference Report: DMCCB Basel Symposium on 'Targeting RNA by Small Molecules' Online, 4th February, 2021.

Autor: Carrel, Aline Lucie, Mulliri, Kleni, Personne, Hippolyte, Javor, Sacha

Publikováno v: Chimia; 2021, Vol. 75 Issue 5, p453-454, 2p