Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Personalised treatment"'
Autor:
Wendy M. Fernandes, Nicola Harris, Ane Zamalloa, Lissette Adofina, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Rosa Miquel, Yoh Zen, Geoff Kelly, James A. Jarvis, Alain Oregioni, Shilpa Chokshi, Antonio Riva, I. Jane Cox
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8924 (2024)
The global burden of liver cancer is increasing. Timely diagnosis is important for optimising the limited available treatment options. Understanding the metabolic consequences of hepatocellular carcinoma (HCC) may lead to more effective treatment opt
Externí odkaz:
https://doaj.org/article/128885824d1b46bfb3233aa17e04a5ab
Akademický článek
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Akademický článek
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Autor:
Qiang Liu, Nemanja Vaci, Ivan Koychev, Andrey Kormilitzin, Zhenpeng Li, Andrea Cipriani, Alejo Nevado-Holgado
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Donepezil, galantamine, rivastigmine and memantine are potentially effective interventions for cognitive impairment in dementia, but the use of these drugs has not been personalised to individual patients yet. We examined whether
Externí odkaz:
https://doaj.org/article/57bd273ee85540ff90a5ed124baaa671
Development of Organs-on-Chips and Their Impact on Precision Medicine and Advanced System Simulation
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2094 (2023)
Drugs may undergo costly preclinical studies but still fail to demonstrate their efficacy in clinical trials, which makes it challenging to discover new drugs. Both in vitro and in vivo models are essential for disease research and therapeutic develo
Externí odkaz:
https://doaj.org/article/e114dbec86be48fca77ed63d9474de56
Akademický článek
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Publikováno v:
Pharmacogenomics and Personalized Medicine, Vol Volume 14, Pp 327-333 (2021)
Ranjit Unnikrishnan,1 Venkatesan Radha,2 Viswanathan Mohan1 1Department of Diabetology, Dr. Mohan’s Diabetes Specialities Centre and Madras Diabetes Research Foundation, Chennai, India; 2Department of Molecular Genetics, Madras Diabetes Research Fo
Externí odkaz:
https://doaj.org/article/18363806c25d490a984394bbc7ec66f0
Autor:
Matthias Pierce, Richard Emsley
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that
Externí odkaz:
https://doaj.org/article/83b12a8d4fb64d0b9a557fd24e255d68
Autor:
Mary Ward, Catherine F. Hughes, J. J. Strain, Rosie Reilly, Conal Cunningham, Anne M. Molloy, Geraldine Horigan, Miriam Casey, Kevin McCarroll, Maurice O’Kane, Michael J. Gibney, Albert Flynn, Janette Walton, Breige A. McNulty, Adrian McCann, Laura Kirwan, John M. Scott, Helene McNulty
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background Genome-wide and clinical studies have linked the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) with hypertension, whilst limited evidence shows that intervention with riboflavin (i.e. the M
Externí odkaz:
https://doaj.org/article/cc6a7206cb9048789def0045b268de51
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Current quantitative methods for personalising psychotherapies for depression are unlikely to be able to inform clinical decision-making for hundreds of years. Novel alternative methods to generate hypotheses for prospective testi
Externí odkaz:
https://doaj.org/article/36965ffb5d374a748a1297b059dc7f2f