Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Perry Scott Brignola"'
Autor:
Christine R. Hoffman, Karen Lackey, Krystal J. Alligood, Mary B. Moyer, Sue H. Kadwell, Earnest Horne, Perry Scott Brignola, Wilson B. Knight, Kevin Blackburn, J. Darren Stuart, Edgar R. Wood, H. Luke Carter
Publikováno v:
Journal of Biological Chemistry. 277:1576-1585
Epidermal growth factor receptor (EGFR), ErbB-2, and ErbB-4 are members of the type 1 receptor tyrosine kinase family. Overexpression of these receptors, especially ErbB-2 and EGFR, has been implicated in multiple forms of cancer. Inhibitors of EGFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61284b3bec4306cfdbc8d396eae850e9
https://doi.org/10.1074/jbc.m105907200
https://doi.org/10.1074/jbc.m105907200
Autor:
Sarva M. Tadepalli, Alex G. Waterson, Perry Scott Brignola, Scott Howard Dickerson, Robert J. Mullin, Thomas R. Caferro, Craig D. Wagner, Hamilton D. Dickson, Dana E. Vanderwall, Kimberly G. Petrov, John C. Ulrich, Michael D. Gaul, Lisa M. Shewchuk, Anne M. Hassell, Kelly Horne Donaldson, Edgar R. Wood, David E. Uehling, Jon D. Williams, Ronald L. Brashear, Barry R. Keith, Wendy L. White, David W. Rusnak, Byron Ellis, Robert J. Griffin, Michael J. Reno
Analysis of the x-ray crystal structure of mono-substituted acetylenic thienopyrimidine 6 complexed with the ErbB family enzyme ErbB-4 revealed a covalent bond between the terminal carbon of the acetylene moiety and the sulfhydryl group of Cys-803 at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee325f04de0f7f4e5e90c473b3e261b
https://europepmc.org/articles/PMC2268535/
https://europepmc.org/articles/PMC2268535/
