Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Perry M. Kirkham"'
Autor:
Wonkyung Oh, Alyssa Min Jung Kim, Deepika Dhawan, Perry M. Kirkham, Raluca Ostafe, Jackeline Franco, Uma K. Aryal, Robert H. Carnahan, Valery Patsekin, J. Paul Robinson, Deborah W. Knapp, Seung-Oe Lim
Publikováno v:
Cancer Research Communications. 3:860-873
Immune checkpoint blockade therapy, one of the most promising cancer immunotherapies, has shown remarkable clinical impact in multiple cancer types. Despite the recent success of immune checkpoint blockade therapy, however, the response rates in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5940a2d7a40661a4e511fc366479fe2
https://doi.org/10.1158/2767-9764.crc-22-0468
https://doi.org/10.1158/2767-9764.crc-22-0468
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
The quality attributes of the purified anti-cPD-L1, 1210E4 (12C) chimeric antibody. A, Canine PD-L1, 12C10E4 chimeric antibody expression construct, pTRIOZ-cIgG2-cPD-L1 12C10E4. B, SDS-PAGE analysis of 12C chimeric antibody purity under nonreducing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd3711fb0d02ce9dca2a78cfe723223
https://doi.org/10.1158/2767-9764.22822013
https://doi.org/10.1158/2767-9764.22822013
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
Working flow chart for production and validation of the cPD-L1 antibody. A, Immunization of antigen, cPD-L1 protein. B, Establishment of hybridomas (over 2,000 clones). C, Evaluation of the cPD-L1 specific antibody by the live cell–based antibody b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f349bf5c084626a7d27c1d75041bb85
https://doi.org/10.1158/2767-9764.22822025
https://doi.org/10.1158/2767-9764.22822025
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
Immune checkpoint blockade therapy, one of the most promising cancer immunotherapies, has shown remarkable clinical impact in multiple cancer types. Despite the recent success of immune checkpoint blockade therapy, however, the response rates in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08daf95a320ab4fd4835db28b003c9dc
https://doi.org/10.1158/2767-9764.c.6647231.v1
https://doi.org/10.1158/2767-9764.c.6647231.v1
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
Evaluation of the caninized cPD-L1 chimeric antibody. A, 12C antibody binding on the BT549cPD-L1 cells. B, Flow cytometric analysis of the 12C chimeric antibody on the BT549cPD-L1 cells. cIgG serves as a negative control. C, 12C chimeric antibody bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29171929ccf015f96aff9b1869cb5934
https://doi.org/10.1158/2767-9764.22822010.v1
https://doi.org/10.1158/2767-9764.22822010.v1
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
The high-throughput screening of therapeutic antibodies. A, Schematic diagram of the cPD-L1 antibody binding assay. BT549 cells expressing cPD-L1 were seeded on 96-well or 384-well plates. cPD-L1 antibodies (from hybridomas) and Alexa Fluor 488–con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862eb8ed26ec7569a2b4ffaef98b93ec
https://doi.org/10.1158/2767-9764.22822019
https://doi.org/10.1158/2767-9764.22822019
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
cPD-L1 antibodies enhance antitumor immunity in the caninized PD-L1 syngeneic mouse model. A, Knock-in strategy of the caninized PD-L1 mice (c57BL/c background). B, Validation of cPD-L1 protein expression in the MB49cPD-L1 cells. Flow cytometric anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b17f754634d4f45c1ddd51708e12e2b
https://doi.org/10.1158/2767-9764.22822016
https://doi.org/10.1158/2767-9764.22822016
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
Pharmacokinetic analysis of 12C chimeric antibody in laboratory dogs. A, Schematic diagram of ELISA for pharamacokinetic analysis. The concentration of the 12C chimeric antibody was measured in the 2 mg/kg (B) or 5 mg/kg (C) 12C antibody-treated dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7f44b02777606a70b288b54fbba785
https://doi.org/10.1158/2767-9764.22822007.v1
https://doi.org/10.1158/2767-9764.22822007.v1
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
Summary of potential adverse events with the initial cPD-L1 antibody administration to laboratory dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fca8f8d69668665bd1d6b8b2c0e4f49
https://doi.org/10.1158/2767-9764.22822004.v1
https://doi.org/10.1158/2767-9764.22822004.v1
Autor:
Seung-Oe Lim, Deborah W. Knapp, J. Paul Robinson, Valery Patsekin, Robert H. Carnahan, Uma K. Aryal, Jackeline Franco, Raluca Ostafe, Perry M. Kirkham, Deepika Dhawan, Alyssa Min Jung Kim, Wonkyung Oh
The list of genes that were altered in the activated canine PBMCs from the nCounter canine immune-oncology panel analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d7cd37ffb1a52c94259ee382da1ed7
https://doi.org/10.1158/2767-9764.22822001.v1
https://doi.org/10.1158/2767-9764.22822001.v1