Likely causal effects of insulin resistance and IGF-1 bioaction on childhood and adult adiposity: a Mendelian randomization study.

Autor: Olwi DI; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Kaisinger LR; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Kentistou KA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Vaudel M; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.; Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, NO-0213, Oslo, Norway., Stankovic S; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Njølstad PR; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, NO-5021, Bergen, Norway., Johansson S; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.; Department of Medical Genetics, Haukeland University Hospital, NO-5021, Bergen, Norway., Perry JRB; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.; Metabolic Research Laboratory, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Day FR; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Ong KK; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK. ken.ong@mrc-epid.cam.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. ken.ong@mrc-epid.cam.ac.uk.

Publikováno v: International journal of obesity (2005) [Int J Obes (Lond)] 2024 Nov; Vol. 48 (11), pp. 1650-1655. Date of Electronic Publication: 2024 Aug 22.

Protein-truncating and rare missense variants in ATM and CHEK2 and associations with cancer in UK Biobank whole-exome sequence data.

Autor: Mukhtar TK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK tm621@medschl.cam.ac.uk.; Department of Primary Care and Public Health, Imperial College London, London, UK., Wilcox N; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Yang X; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Naven M; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Mavaddat N; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Perry JRB; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Gardner E; Metabolic Research Laboratory, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Publikováno v: Journal of medical genetics [J Med Genet] 2024 Oct 23; Vol. 61 (11), pp. 1016-1022. Date of Electronic Publication: 2024 Oct 23.

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.

Autor: Lockhart SM; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. sl908@cam.ac.uk., Muso M; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. mm2445@cam.ac.uk., Zvetkova I; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lam BYH; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ferrari A; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA., Schoenmakers E; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Duckett K; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Leslie J; Newcastle Fibrosis Research Group, Bioscience Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Collins A; Newcastle Fibrosis Research Group, Bioscience Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Romartínez-Alonso B; Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Tadross JA; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Histopathology and Cambridge Genomics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Jia R; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Gardner EJ; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Kentistou K; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Zhao Y; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Day F; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Mörseburg A; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Rainbow K; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Rimmington D; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Mastantuoni M; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Harrison J; VPD Heart and Lung Research Institute, Dept. Medicine, University of Cambridge, Cambridge, UK., Nus M; VPD Heart and Lung Research Institute, Dept. Medicine, University of Cambridge, Cambridge, UK., Guma'a K; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Sherratt-Mayhew S; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Jiang X; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Smith KR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Paul DS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Jenkins B; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; NIHR BRC Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Koulman A; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; NIHR BRC Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Pietzner M; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Langenberg C; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Wareham N; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Yeo GS; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Chatterjee K; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Schwabe J; Department of Histopathology and Cambridge Genomics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Oakley F; Newcastle Fibrosis Research Group, Bioscience Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Mann DA; Newcastle Fibrosis Research Group, Bioscience Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Tontonoz P; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA., Coll AP; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ong K; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Perry JRB; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., O'Rahilly S; Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. so104@cam.ac.uk.; NIHR Cambridge Biomedical Research Centre, Cambridge, UK. so104@cam.ac.uk.

Publikováno v: Nature metabolism [Nat Metab] 2024 Oct; Vol. 6 (10), pp. 1922-1938. Date of Electronic Publication: 2024 Sep 25.

Genetic links between ovarian ageing, cancer risk and de novo mutation rates.

Autor: Stankovic S; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Shekari S; University of Exeter Medical School, University of Exeter, Exeter, UK.; School of Public Health, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Huang QQ; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Gardner EJ; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ivarsdottir EV; deCODE Genetics/Amgen, Reykjavik, Iceland., Owens NDL; University of Exeter Medical School, University of Exeter, Exeter, UK., Mavaddat N; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Azad A; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hawkes G; University of Exeter Medical School, University of Exeter, Exeter, UK., Kentistou KA; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Beaumont RN; University of Exeter Medical School, University of Exeter, Exeter, UK., Day FR; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Zhao Y; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Jonsson H; deCODE Genetics/Amgen, Reykjavik, Iceland., Rafnar T; deCODE Genetics/Amgen, Reykjavik, Iceland., Tragante V; deCODE Genetics/Amgen, Reykjavik, Iceland., Sveinbjornsson G; deCODE Genetics/Amgen, Reykjavik, Iceland., Oddsson A; deCODE Genetics/Amgen, Reykjavik, Iceland., Styrkarsdottir U; deCODE Genetics/Amgen, Reykjavik, Iceland., Gudmundsson J; deCODE Genetics/Amgen, Reykjavik, Iceland., Stacey SN; deCODE Genetics/Amgen, Reykjavik, Iceland., Gudbjartsson DF; deCODE Genetics/Amgen, Reykjavik, Iceland., Kennedy K; University of Exeter Medical School, University of Exeter, Exeter, UK., Wood AR; University of Exeter Medical School, University of Exeter, Exeter, UK., Weedon MN; University of Exeter Medical School, University of Exeter, Exeter, UK., Ong KK; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Wright CF; University of Exeter Medical School, University of Exeter, Exeter, UK., Hoffmann ER; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sulem P; deCODE Genetics/Amgen, Reykjavik, Iceland., Hurles ME; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Ruth KS; University of Exeter Medical School, University of Exeter, Exeter, UK., Martin HC; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland., Perry JRB; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.; Metabolic Research Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk., Murray A; University of Exeter Medical School, University of Exeter, Exeter, UK. A.Murray@exeter.ac.uk.

Publikováno v: Nature [Nature] 2024 Sep; Vol. 633 (8030), pp. 608-614. Date of Electronic Publication: 2024 Sep 11.

Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum.

Autor: Kentistou KA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Kaisinger LR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Stankovic S; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Vaudel M; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway., Mendes de Oliveira E; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Messina A; Division of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Liu X; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Busch AS; Department of General Pediatrics, University of Münster, Münster, Germany.; Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Helgason H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Santoni F; Division of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Petricek KM; Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Berlin, Germany., Zouaghi Y; Division of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Huang-Doran I; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Gudbjartsson DF; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Bratland E; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Gardner EJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Zhao Y; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Jia RY; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Riggan MJ; Department of Gynecology, Duke University Medical Center, Durham, NC, USA., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Yazdanpanah M; Research Center of the Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada., Yazdanpanah N; Research Center of the Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada., Bradfield JP; Quantinuum Research, Wayne, PA, USA.; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Broer L; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Cousminer DL; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Franke LH; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Girotto G; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., He C; Department of Internal Medicine, Division of Medical Oncology, University of Kentucky College of Medicine, Lexington, KY, USA.; Cancer Prevention and Control Research Program, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Järvelin MR; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Kamatani Y; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, USA., Mägi R; Institute of Genomics, University of Tartu, Tartu, Estonia., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, University of Queensland, Brisbane, Queensland, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Meisinger C; Epidemiology, Medical Faculty, University of Augsburg, University Hospital of Augsburg, Augsburg, Germany., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Nutile T; Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy., Concas MP; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Polašek O; University of Split School of Medicine, Split, Croatia.; Algebra University College, Zagreb, Croatia., Porcu E; Institute of Genetics and Biomedical Research, National Research Council, Sardinia, Italy.; Department of Biomedical Sciences, University of Sassari, Sassari, Italy., Ring SM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Sala C; Division of Genetics and Cell Biology, San Raffele Hospital, Milano, Italy., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tanaka T; National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wang CA; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.; Hunter Medical Research Institute, Newcastle, New South Wales, Australia., Willemsen G; Department of Biological Psychology, Vrije Universiteit Amsterdam; Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands., Zygmunt M; Clinic of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany., Ahearn TU; Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Bethesda, MD, USA., Andrulis IL; Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Anton-Culver H; Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Auer PL; Division of Biostatistics, Institute for Health and Equity and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA., Barnes CLK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Beckmann MW; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Berrington de Gonzalez A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Bogdanova NV; Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.; N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus., Bojesen SE; Copenhagen General Population Study, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Canzian F; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN, USA., Cox A; Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK., Crisponi L; Institute of Genetics and Biomedical Research, National Research Council, Sardinia, Italy., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Daly MB; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA., Demerath EW; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Devilee P; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., De Vivo I; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Dwek M; School of Life Sciences, University of Westminster, London, UK., Eriksson JG; Department of General Practice and Primary Healthcare, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.; Yong Loo Lin School of Medicine, Department of Obstetrics and Gynecology and Human Potential Translational Research Programme, National University Singapore, Singapore City, Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore City, Singapore., Fasching PA; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Fernandez-Rhodes L; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA., Ferreli L; Institute of Genetics and Biomedical Research, National Research Council, Sardinia, Italy., Fletcher O; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Gago-Dominguez M; Genomic Medicine Group, International Cancer Genetics and Epidemiology Group Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS Santiago de Compostela, Coruña, Spain., García-Closas M; Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Bethesda, MD, USA., García-Sáenz JA; Medical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., González-Neira A; Human Genotyping Unit-CeGen, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Grallert H; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Guénel P; Team 'Exposome and Heredity', CESP, Gustave Roussy INSERM, University Paris-Saclay, UVSQ, Orsay, France., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Oncology, Södersjukhuset, Stockholm, Sweden., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hart RJ; Division of Obstetrics and Gynaecology, University of Western Australia, Crawley, Western Australia, Australia., Hickey M; Department of Obstetrics and Gynaecology, University of Melbourne and The Royal Women's Hospital, Parkville, Victoria, Australia., Hooning MJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Hoppe R; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam; Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands., Hu FB; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health School of Public Health, Boston, MA, USA., Huebner H; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Hunter DJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Jernström H; Oncology, Department of Clinical Sciences in Lund, Lund University, Lund, Sweden., John EM; Department of Epidemiology and Population Health, Stanford University School of Medicine Stanford, Stanford, CA, USA.; Department of Medicine, Division of Oncology Stanford Cancer Institute, Stanford University School of Medicine Stanford, Stanford, CA, USA., Karasik D; Hebrew SeniorLife Institute for Aging Research, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Khusnutdinova EK; Institute of Biochemistry and Genetics of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia., Kristensen VN; Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Lacey JV; Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA., Lambrechts D; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, VIB, Leuven, Belgium., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Lind PA; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mannermaa A; Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.; 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Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sovio U; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Stöckl D; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; State Institute of Health, Bavarian Health and Food Safety Authority (LGL), Oberschleissheim, Germany., Sudlow C; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; 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Publikováno v: Nature genetics [Nat Genet] 2024 Aug; Vol. 56 (8), pp. 1763-1764.