Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Perry D Moerland"'
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182983 (2017)
The retinal pigment epithelium (RPE) is a neural monolayer lining the back of the eye. Degeneration of the RPE leads to severe vision loss in, so far incurable, diseases such as age-related macular degeneration and some forms of retinitis pigmentosa.
Externí odkaz:
https://doaj.org/article/4f16360e9f6e40bc8088f1ea634a30c4
Autor:
Nicolette W Duijvis, Perry D Moerland, Cindy Kunne, Monique M W Slaman, Faas H van Dooren, Esther W Vogels, Wouter J de Jonge, Sybren L Meijer, Kees Fluiter, Anje A Te Velde
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185097 (2017)
MicroRNAs (miRNAs) are epigenetically involved in regulating gene expression. They may be of importance in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to determine the role of miRNAs by their specific blocking in t
Externí odkaz:
https://doaj.org/article/1cc265b99c0d42be9d0111c14b685335
Autor:
Luuk E. de Vries, Aldo Jongejan, Jennifer Monteiro Fortes, Rawien Balesar, Annemieke J. M. Rozemuller, Perry D. Moerland, Inge Huitinga, Dick F. Swaab, Joost Verhaagen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnin
Externí odkaz:
https://doaj.org/article/e03528769b2a4a3cb0f3eb56cfdfb93b
Autor:
Aletta M. R. van den Bosch, Marlijn van der Poel, Nina L. Fransen, Maria C. J. Vincenten, Anneleen M. Bobeldijk, Aldo Jongejan, Hendrik J. Engelenburg, Perry D. Moerland, Joost Smolders, Inge Huitinga, Jörg Hamann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Microglia nodules (HLA-DR+ cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first stage of multiple sclerosis (MS) lesion formation. We show that microglia nodules are
Externí odkaz:
https://doaj.org/article/598c1f7d0a794ef3b7096efd7cbff052
Autor:
Miranda van Uitert, Perry D Moerland, Daniel A Enquobahrie, Hannele Laivuori, Joris A M van der Post, Carrie Ris-Stalpers, Gijs B Afink
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132468 (2015)
Studies using the placental transcriptome to identify key molecules relevant for preeclampsia are hampered by a relatively small sample size. In addition, they use a variety of bioinformatics and statistical methods, making comparison of findings cha
Externí odkaz:
https://doaj.org/article/4e64aa135aef45088ce74fe96a1b186c
Autor:
Teresa Palao, Karl Swärd, Aldo Jongejan, Perry D Moerland, Judith de Vos, Angela van Weert, Silvia M Arribas, Gergely Groma, Ed vanBavel, Erik N T P Bakker
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137027 (2015)
Small arteries are known to develop functional and structural alterations in hypertension. However, the mechanisms of this remodeling are not fully understood. We hypothesized that altered gene expression is associated with the development of hyperte
Externí odkaz:
https://doaj.org/article/e5af52345d744387a64ad8a3ad59f240
Autor:
Wouter Wegdam, Carmen A Argmann, Gertjan Kramer, Johannes P Vissers, Marrije R Buist, Gemma G Kenter, Johannes M F G Aerts, Danielle Meijer, Perry D Moerland
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108046 (2014)
PurposeTo identify proteins and (molecular/biological) pathways associated with differences between benign and malignant epithelial ovarian tumors.Experimental proceduresSerum of six patients with a serous adenocarcinoma of the ovary was collected be
Externí odkaz:
https://doaj.org/article/034990b2eb1c49cca4433dc419d364d4
Autor:
Tamara T Koopmann, Michiel E Adriaens, Perry D Moerland, Roos F Marsman, Margriet L Westerveld, Sean Lal, Taifang Zhang, Christine Q Simmons, Istvan Baczko, Cristobal dos Remedios, Nanette H Bishopric, Andras Varro, Alfred L George, Elisabeth M Lodder, Connie R Bezzina
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97380 (2014)
In recent years genome-wide association studies (GWAS) have uncovered numerous chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia predisposition. A considerable fraction of these loci lie within inter-genic re
Externí odkaz:
https://doaj.org/article/326b3c5dcecf434d8c8e44ecb7c564f8
Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis.
Autor:
C Emily Kleinrouweler, Miranda van Uitert, Perry D Moerland, Carrie Ris-Stalpers, Joris A M van der Post, Gijs B Afink
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68991 (2013)
OBJECTIVE: To systematically review the literature on human gene expression data of placental tissue in pre-eclampsia and to characterize a meta-signature of differentially expressed genes in order to identify novel putative diagnostic markers. DATA
Externí odkaz:
https://doaj.org/article/a65fee4548db48ea8ece5d2ede54d917
Autor:
Elisabeth M Lodder, Brendon P Scicluna, Annalisa Milano, Albert Y Sun, Hao Tang, Carol Ann Remme, Perry D Moerland, Michael W T Tanck, Geoffrey S Pitt, Douglas A Marchuk, Connie R Bezzina
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003113 (2012)
Atrio-ventricular conduction disease is a common feature in Mendelian rhythm disorders associated with sudden cardiac death and is characterized by prolongation of the PR interval on the surface electrocardiogram (ECG). Prolongation of the PR interva
Externí odkaz:
https://doaj.org/article/7f87a5d74a0941c5b627ead7c4c4e488