Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Perry Clark Heath"'
Autor:
Sze Wing Wong, Peter G. Houghton, David M. Coppert, Mccauley Mary Kay, Utpal K. Singh, Roger B. Scherer, Michael E. Kopach, Mark S. Kerr, Perry Clark Heath, Mark A. Pietz, Rhodes Gary Anthony, Gregg Alan Tharp, Bret A. Astleford
Publikováno v:
Organic Process Research & Development. 19:543-550
A convergent synthesis of (S)-(4-benzylmorpholin-2-yl)(morpholino)methanone methanesulfonate (1), a key regulatory starting material for edivoxetine·HCl, was developed at Eli Lilly & Company. This novel synthesis utilizes d-serine as the source of c
Autor:
Jacob R. Remacle, Amy C. DeBaillie, Christopher P. Ley, Thomas Michael Wilson, Nicholas A. Magnus, Varie David Lee, Perry Clark Heath, Timothy M. Braden, Jonas Y. Buser
Publikováno v:
Organic Process Research & Development. 16:830-835
This article describes the development and optimization of chemical reactions and subsequent multikilogram preparation of the glucokinase activator (R)-1 to fund clinical evaluation as a potential therapeutic for type II diabetes. The major process d
Autor:
Justin C. Smith, Samuel Dean Larsen, Leland Otto Weigel, Jeffrey A. Ward, Ryan J. Linder, Susan M. Reutzel-Edens, Perry Clark Heath, Stanley P. Kolis, Marvin M. Hansen, Marcella T. Clayton, Sandra S. K. Borders, Shella Lenyonga Tameze
Publikováno v:
Organic Process Research & Development. 13:198-208
An efficient and scalable synthesis of the clinical candidate 1 is described. The first-generation synthesis built the enantioenriched nitro-aminoindanol core from 6-nitroindanone using a five-step literature route. The second-generation route used a
Autor:
Richard Lowe, Charles Q. Huang, Jeffery P. Whitten, Leland Otto Weigel, Perry Clark Heath, Mccarthy James R
Publikováno v:
Tetrahedron Letters. 42:1607-1610
Acylation of 1,3-disubstituted thioureas with methyl malonyl chloride followed by base-catalyzed cyclization leads to the preparation of 1,3-disubstituted-2-thiobarbituric acids in high yield.
Autor:
J. J. Droste, Perry Clark Heath, Harry A. Kay, Richard D. Miller, Leland Otto Weigel, James E. Audia, Jill H. Eifert, Dale W. Holme, J. M. Dunigan, Thomas F. Rainey, John L Bowers, Jorge M. Olivares
Publikováno v:
Tetrahedron Letters. 37:4121-4124
In one operation, metalloenamines derived from R -phenylethylamine (PEA) and a β-tetralone were treated with an electrophile followed by acrylic anhydride. The unpurified lactams were reduced to give 10b-angular benzoquinolinones (BQs).
Autor:
James P. Wepsiec, Leland Otto Weigel, Bret A. Astleford, Kress Thomas Joseph, Jack B. Deeter, Perry Clark Heath, Samantha K. Janisse, James E. Audia
Publikováno v:
The Journal of Organic Chemistry. 61:4450-4454
Publikováno v:
ChemInform. 23
β-Ketoesters useful for elaboration to carbacephems were synthesized from a variety of enantiomerically pure diesters. Use of phenyl esters to direct the regioselectivity was demonstrated.
Publikováno v:
ChemInform. 23
Autor:
Richard D. Miller, J. M. Dunigan, Jill H. Eifert, John L Bowers, Thomas F. Rainey, Perry Clark Heath, J. J. Droste, Harry A. Kay, Jorge M. Olivares, Dale W. Holme, Leland Otto Weigel, James E. Audia
Publikováno v:
ChemInform. 27
In one operation, metalloenamines derived from R -phenylethylamine (PEA) and a β-tetralone were treated with an electrophile followed by acrylic anhydride. The unpurified lactams were reduced to give 10b-angular benzoquinolinones (BQs).
Autor:
James E. Audia, Jack B. Deeter, Leland Otto Weigel, James P. Wepsiec, Kress Thomas Joseph, Bret A. Astleford, S. K. Janisse, Perry Clark Heath
Publikováno v:
ChemInform. 27