Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Perry C. Kennedy"'
Autor:
Timothy L. Macdonald, Olivier Peyruchaud, Marion David, Tao Huang, Perry C. Kennedy, Thomas P. Mathews, Ran Zhu, Kevin R. Lynch, Jose L. Tomsig
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 338:879-889
Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)-S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and migration. On a larger physio
Autor:
Oana Nicoara, Andrew J. Kennedy, Kevin R. Lynch, Yugesh Kharel, Andrew J. Morris, Thomas P. Mathews, Brian R. Wamhoff, Manjula Sunkara, Timothy L. Macdonald, Perry C. Kennedy
Publikováno v:
Journal of Medicinal Chemistry. 53:2766-2778
Sphingosine 1-phosphate (S1P), a potent phospholipid growth and trophic factor, is synthesized in vivo by two sphingosine kinases. Thus these kinases have been proposed as important drug targets for treatment of hyperproliferative diseases and inflam
Autor:
Michael D. Davis, Perry C. Kennedy, Ashley H. Snyder, Timothy L. Macdonald, Thomas P. Mathews, Yugesh Kharel, Kevin R. Lynch, Frank W. Foss
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:6123-6136
In the search for bioactive sphingosine 1-phosphate (S1P) receptor ligands, a series of 2-amino-2-heterocyclic-propanols were synthesized. These molecules were discovered to be substrates of human-sphingosine kinases 1 and 2 (SPHK1 and SPHK2). When p
Autor:
Ashley H. Snyder, Kevin R. Lynch, Timothy L. Macdonald, Lisa Schaffter, Perry C. Kennedy, Yugesh Kharel, Qin Sun, Ran Zhu
Publikováno v:
Journal of Medicinal Chemistry. 50:6428-6435
Compound 1 (FTY720, Fingolimod) represents a new generation of immunosuppressant that modulates lymphocyte trafficking by interacting with the S1P(1) receptor. Compound 1 also provides a template molecule for studying the molecular biology of S1P rec
Autor:
Shelley B. Hooks, Michael V. Stoeling, Ronald T. Riley, Phillip Callihan, Kevin R. Lynch, Nicholas C. Zitomer, Perry C. Kennedy
Publikováno v:
The FASEB Journal. 26
In vivo and in vitro studies suggest a crucial role for Sphingosine 1-phosphate (S1P) and its receptors in the development of the nervous system. Dihydrosphingosine 1-phosphate (dhS1P), a reduced form of S1P, is an agonist at S1P receptors, but the p
Autor:
Morgan L. Moyer, Amanda M. Gellett, Yugesh Kharel, Thomas P. Mathews, Timothy L. Macdonald, Perry C. Kennedy, Kevin R. Lynch, Jose L. Tomsig
Publikováno v:
The Biochemical journal. 440(3)
S1P (sphingosine 1-phosphate) is a signalling molecule involved in a host of cellular and physiological functions, most notably cell survival and migration. S1P, which signals via a set of five G-protein-coupled receptors (S1P1–S1P5), is formed by
Publikováno v:
The FASEB Journal. 22
Autor:
Myron L. Toews, Karen M. Carter, Perry C. Kennedy, Nancy A. Schulte, Timothy L. Macdonald, James E. East, Kevin R. Lynch
Publikováno v:
MedChemComm. 2:325
Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention due to its role in neoplastic diseases. Our group has developed a potent dual LPA1/LPA3 receptor antagonist, VPC51098 (LPA1 IC(50) = 84 nM, LPA1 IC(50) = 48 nM) that contai
Autor:
Yugesh Kharel, Amanda M. Gellett, Jose L. Tomsig, Perry C. Kennedy, Morgan L. Moyer, Kevin R. Lynch
Publikováno v:
Biochemical Journal; Dec2011, Vol. 440 Issue 3, p345-353, 9p
Autor:
Ran Zhu, Ashley H. Snyder, Yugesh Kharel, Lisa Schaffter, Qin Sun, Perry C. Kennedy, Kevin R. Lynch, Timothy L. Macdonald
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 25, p6428-6435, 8p