A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Autor: Coviello, Andrea D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimaki, Terho, Keildson, Sarah, Lunetta, Kathryn L., He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Mei, Yong, Koster, Annemarie, Lohman, Kurt, Lyytikainen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R., Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania, Biffar, Reiner, Brabant, Georg, Cox, David G., Chen, Yuhui, Cummings, Steven, Ferrucci, Luigi, Gunter, Marc J., Hankinson, Susan E., Martikainen, Hannu, Hofman, Albert, Homuth, Georg, Illig, Thomas, Jansson, John-Olov, Johnson, Andrew D., Karasik, David, Karlsson, Magnus, Kettunen, Johannes, Kiel, Douglas P., Kraft, Peter, Liu, Jingmin, Ljunggren, Östen, Lorentzon, Mattias, Maggio, Marcello, Markus, Marcello R. P., Mellstrom, Dan, Miljkovic, Iva, Mirel, Daniel, Nelson, Sarah, Papunen, Laure Morin, Peeters, Petra H. M., Prokopenko, Inga, Raffel, Leslie, Reincke, Martin, Reiner, Alex P., Rexrode, Kathryn, Rivadeneira, Fernando, Schwartz, Stephen M., Siscovick, David, Soranzo, Nicole, Stockl, Doris, Tworoger, Shelley, Uitterlinden, Andre G., van Gils, Carla H., Vasan, Ramachandran S., Wichmann, H. -Erich, Zhai, Guangju, Bhasin, Shalender, Bidlingmaier, Martin, Chanock, Stephen J., De Vivo, Immaculata, Harris, Tamara B., Hunter, David J., Kahonen, Mika, Liu, Simin, Ouyang, Pamela, Spector, Tim D., van der Schouw, Yvonne T., Viikari, Jorma, Wallaschofski, Henri, McCarthy, Mark I., Frayling, Timothy M., Murray, Anna, Franks, Steve, Jarvelin, Marjo-Riitta, de Jong, Frank H., Raitakari, Olli, Teumer, Alexander, Ohlsson, Claes, Murabito, Joanne M., Perry, John R. B.

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181141

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Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study

Autor: Canton, Ana P M, Tinano, Flávia R, Guasti, Leonardo, Montenegro, Luciana R, Ryan, Fiona, Shears, Deborah, de Melo, Maria Edna, Gomes, Larissa G, Piana, Mariana P, Brauner, Raja, Espino-Aguilar, Rafael, Escribano-Muñoz, Arancha, Paganoni, Alyssa, Read, Jordan E, Korbonits, Márta, Seraphim, Carlos E, Costa, Silvia S, Krepischi, Ana Cristina, Jorge, Alexander A L, David, Alessia, Kaisinger, Lena R, Ong, Ken K, Perry, John R B, Abreu, Ana Paula, Kaiser, Ursula B, Argente, Jesús, Mendonca, Berenice B, Brito, Vinicius N, Howard, Sasha R ^†, Latronico, Ana Claudia ^{†, *}

Publikováno v: In The Lancet Diabetes & Endocrinology August 2023 11(8):545-554

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