Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis

Autor: Céline Ortega-Ferreira, Perrine Soret, Gautier Robin, Silvia Speca, Sandra Hubert, Marianne Le Gall, Emiko Desvaux, Manel Jendoubi, Julie Saint-Paul, Loubna Chadli, Agnès Chomel, Sylvie Berger, Emmanuel Nony, Béatrice Neau, Benjamin Fould, Anne Licznar, Franck Levasseur, Thomas Guerrier, Sahar Elouej, Sophie Courtade-Gaïani, Nicolas Provost, The Quyen Nguyen, Julien Verdier, David Launay, Frédéric De Ceuninck

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Systemic sclerosis (SSc) is an autoimmune, inflammatory and fibrotic disease with limited treatment options. Developing new therapies is therefore crucial to address patient needs. To this end, we focused on galectin-3 (Gal-3), a lectin know

Externí odkaz: https://doaj.org/article/b4ac4a8d08c9436badd6ef4d718b8e03

Lasso regularization for left-censored Gaussian outcome and high-dimensional predictors

Autor: Perrine Soret, Marta Avalos, Linda Wittkop, Daniel Commenges, Rodolphe Thiébaut

Publikováno v: BMC Medical Research Methodology, Vol 18, Iss 1, Pp 1-13 (2018)

Abstract Background Biological assays for the quantification of markers may suffer from a lack of sensitivity and thus from an analytical detection limit. This is the case of human immunodeficiency virus (HIV) viral load. Below this threshold the exa

Externí odkaz: https://doaj.org/article/47e534adfbc3475b9205ebfffda21129

Syndrome de Gougerot-Sjögren: Vers une médecine de précision

Autor: Laurence Laigle, Christelle Le Dantec, Perrine Soret, Emiko Desvaux, Sandra Hubert, Nathan Foulquier, Philippe Moingeon, Mickaël Guedj, Jacques-Olivier Pers

Publikováno v: médecine/sciences
médecine/sciences, 2022, 38 (2), pp.148-151. ⟨10.1051/medsci/2021258⟩

International audience; No abstract available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139506a924e6dbf23ec8ca11f9a87fcd
https://hal.science/hal-03581011/document

New Insights in Microbial Species Predicting Lung Function Decline in CF: Lessons from the MucoFong Project

Autor: Perrine Soret, Rodolphe Thiébaut, Michael Fayon, Marta Avalos-Fernandez, Florian Lussac-Sorton, Raphaël Enaud, Florence Francis, Laurence Delhaes, Stéphanie Bui

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, MDPI, 2021, 10 (16), pp.3725. ⟨10.3390/jcm10163725⟩
Journal of Clinical Medicine, Vol 10, Iss 3725, p 3725 (2021)
Volume 10
Issue 16
Journal of Clinical Medicine, 2021, 10 (16), pp.3725. ⟨10.3390/jcm10163725⟩

International audience; Several predictive models have been proposed to understand the microbial risk factors associated with cystic fibrosis (CF) progression. Very few have integrated fungal airways colonisation, which is increasingly recognized as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22223dba2fa8fd0d0d36f3e58d1595d8
https://hal.inria.fr/hal-03328143

Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis

Autor: Perrine, Soret, Louise-Eva, Vandenborght, Florence, Francis, Noémie, Coron, Raphael, Enaud, Marta, Avalos, Thierry, Schaeverbeke, Patrick, Berger, Michael, Fayon, Rodolphe, Thiebaut, Laurence, Delhaes, Dominique, Turck

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.3589. ⟨10.1038/s41598-020-60015-4⟩
Scientific Reports, 2020, 10 (1), pp.3589. ⟨10.1038/s41598-020-60015-4⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

Lung infections play a critical role in cystic fibrosis (CF) pathogenesis. CF respiratory tract is now considered to be a polymicrobial niche and advances in high-throughput sequencing allowed to analyze its microbiota and mycobiota. However, no NGS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71079619e510fddb3bd997df8b0af561
https://www.hal.inserm.fr/inserm-02497484/file/s41598-020-60015-4.pdf