Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Perrine Castets"'
Autor:
Denis Falcetta, Sandrine Quirim, Ilaria Cocchiararo, Florent Chabry, Marine Théodore, Adeline Stiefvater, Shuo Lin, Lionel Tintignac, Robert Ivanek, Jochen Kinter, Markus A. Rüegg, Michael Sinnreich, Perrine Castets
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Background Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs) deteriorate in skeletal muscle from DM1 patients and mouse models thereof. Howe
Externí odkaz:
https://doaj.org/article/af7b40e3a50f4837b9d4e0a855e85038
Autor:
Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard, Markus A. Rüegg
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Background The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, PKC, and SGK. Inactiva
Externí odkaz:
https://doaj.org/article/7cce3b4272cf4ef585f62fc6aa66cecd
Autor:
Perrine Castets, Nathalie Rion, Marine Théodore, Denis Falcetta, Shuo Lin, Markus Reischl, Franziska Wild, Laurent Guérard, Christopher Eickhorst, Marielle Brockhoff, Maitea Guridi, Chikwendu Ibebunjo, Joseph Cruz, Michael Sinnreich, Rüdiger Rudolf, David J. Glass, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promot
Externí odkaz:
https://doaj.org/article/ad2327d58d6a49b7a54e496210a1a5f2
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and skeletal muscle fibers. NMJs allow all voluntary movements, and ensure vital functions like breathing. Changes in the structure and function of NMJs are hallmarks o
Externí odkaz:
https://doaj.org/article/475823ef688142baa99220cbc21569ee
Autor:
Sefika Ozcelik, Graham Fraser, Perrine Castets, Véronique Schaeffer, Zhiva Skachokova, Karin Breu, Florence Clavaguera, Michael Sinnreich, Ludwig Kappos, Michel Goedert, Markus Tolnay, David Theo Winkler
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62459 (2013)
Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have recently shown that trehalose reduces tau pathology in a tauopathy mouse model by stimulat
Externí odkaz:
https://doaj.org/article/9f9e33e4ac754d4abf60316d4482e73d
Autor:
Mathieu Rederstorff, Perrine Castets, Sandrine Arbogast, Jeanne Lainé, Stéphane Vassilopoulos, Maud Beuvin, Odile Dubourg, Alban Vignaud, Arnaud Ferry, Alain Krol, Valérie Allamand, Pascale Guicheney, Ana Ferreiro, Alain Lescure
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23094 (2011)
Selenium is an essential trace element and selenoprotein N (SelN) was the first selenium-containing protein shown to be directly involved in human inherited diseases. Mutations in the SEPN1 gene, encoding SelN, cause a group of muscular disorders cha
Externí odkaz:
https://doaj.org/article/be4eb237517f44e19d3891ab804ea5cd
Autor:
Denis Falcetta, Sandrine Quirim, Ilaria Cocchiararo, Mélanie Cornut, Marine Théodore, Adeline Stiefvater, Shuo Lin, Lionel Tintignac, Robert Ivanek, Jochen Kinter, Markus A. Rüegg, Michael Sinnreich, Perrine Castets
Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs) deteriorate in skeletal muscle from DM1 patients and mouse models thereof. However, the underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd6959223d4d67e3ec3a6dd84cecbfd
https://doi.org/10.1101/2023.03.08.531688
https://doi.org/10.1101/2023.03.08.531688
Autor:
Gaëtan Juban, Adrien Bertrand-Chapel, Swann Meyer, Anita Kneppers, Paul Huchedé, Cindy Gallerne, Ruth Benayoun, Enzo Cohen, Alejandro Lopez-Gonzales, Sabrina Ben Larbi, Marion Creveaux, Lucile Vaille, Amélie Bouvier, Marine Théodore, Laura Broutier, Aurélie Dutour, Martine Cordier-Bussat, Jean-Yves Blay, Nathalie Streichenberger, Cécile Picard, Nadège Corradini, Valérie Allamand, Perrine Castets, Rémi Mounier, Marie Castets
Rhabdomyosarcoma (RMS) is the most frequent form of paediatric soft-tissue sarcoma and remains a medical challenge, holding in failure current therapeutic strategies. RMS shares histological features with cells of the muscle lineage and this cancer i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be333ef6d9d2fac4f89e01eecd5a0eb5
https://doi.org/10.1101/2023.03.07.531559
https://doi.org/10.1101/2023.03.07.531559
Publikováno v:
Experimental Cell Research. 421:113392
C2C12 cells are widely used in the muscle field, as they differentiate easily into myotubes and show limited constraints to culture as compared to primary myoblasts. Both C2C12 and primary myoblasts are hard to transfect, which affects downstream exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156e239ae895fc2e3e5cec87b62484d2
https://doi.org/10.1016/j.yexcr.2022.113392
https://doi.org/10.1016/j.yexcr.2022.113392
Autor:
Florence Fauvelle, Juliette Geoffray, Perrine Castets, Severine Fagault, Manon Carre, David Neves, Marion Creveaux, Fanny Basset, Kathrin Weber, Mailys Rossi, Paul Huchede, Joseph Bisaccia, Marie Castets, Jonathan Vial
Rhabdomyosarcoma (RMS) is the most frequent form of pediatric soft-tissue sarcoma. It is divided into 2 main subtypes: ERMS (embryonal) and ARMS (alveolar). Current treatments are based on chemotherapy, surgery and radiotherapy. 5-year survival rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2db79988a0f5e583435820369e216e