Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex

Autor: Beth Mann, Jeremy Chase Crawford, Kavya Reddy, Josi Lott, Yong Ha Youn, Geli Gao, Cliff Guy, Ching-Heng Chou, Daniel Darnell, Sanchit Trivedi, Perrine Bomme, Allister J. Loughran, Paul G. Thomas, Young-Goo Han, Elaine I. Tuomanen

Publikováno v: mBio, Vol 14, Iss 3 (2023)

ABSTRACT Microbial components have a range of direct effects on the fetal brain. However, little is known about the cellular targets and molecular mechanisms that mediate these effects. Neural progenitor cells (NPCs) control the size and architecture

Externí odkaz: https://doaj.org/article/edfca55a494f487c9d53c10181500628

Salmonella enters a dormant state within human epithelial cells for persistent infection.

Autor: Chak Hon Luk, Camila Valenzuela, Magdalena Gil, Léa Swistak, Perrine Bomme, Yuen-Yan Chang, Adeline Mallet, Jost Enninga

Publikováno v: PLoS Pathogens, Vol 17, Iss 4, p e1009550 (2021)

Salmonella Typhimurium (S. Typhimurium) is an enteric bacterium capable of invading a wide range of hosts, including rodents and humans. It targets different host cell types showing different intracellular lifestyles. S. Typhimurium colonizes differe

Externí odkaz: https://doaj.org/article/abe40c221d184140bdacbaca1af67a15

Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of

Autor: Sarah Sze Wah, Wong, Sarah, Dellière, Natalia, Schiefermeier-Mach, Lukas, Lechner, Susanne, Perkhofer, Perrine, Bomme, Thierry, Fontaine, Anders G, Schlosser, Grith L, Sorensen, Taruna, Madan, Uday, Kishore, Vishukumar, Aimanianda

Publikováno v: The Cell Surface

Highlights • Surfactant protein D (SP-D), a C-type lectin and a major humoral immune component in the human lung-alveoli, shows direct growth inhibitory effect on Aspergillus fumigatus, an airborne opportunistic fungal pathogen. • SP-D treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abd6ffbd5760072f7678f4728a99628b
https://pubmed.ncbi.nlm.nih.gov/35118215

Direct interactions with influenza promote bacterial adherence during respiratory infections

Autor: Hannah M. Rowe, Victoria A. Meliopoulos, Amy R. Iverson, Jason W. Rosch, Perrine Bomme, Stacey Schultz-Cherry

Publikováno v: Nat Microbiol

Epidemiological observations and animal models have long shown synergy between influenza virus infections and bacterial infections. Influenza virus infection leads to an increase in both the susceptibility to secondary bacterial infections and the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ecc7c819f0673f2fa0fc3bf1f6a5ff
https://doi.org/10.1038/s41564-019-0447-0

Salmonella enters a dormant state within human epithelial cells for persistent infection

Autor: Perrine Bomme, Camila Valenzuela, Magdalena Gil, Yuen-Yan Chang, Chak Hon Luk, Jost Enninga, Adeline Mallet, Léa Swistak

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2021, 17 (4), pp.e1009550. ⟨10.1371/journal.ppat.1009550⟩
PLoS Pathogens, Public Library of Science, 2021, 17 (4), pp.e1009550. ⟨10.1371/journal.ppat.1009550⟩
PLoS Pathogens, Vol 17, Iss 4, p e1009550 (2021)
PLOS Pathogens

Salmonella Typhimurium (S. Typhimurium) is an enteric bacterium capable of invading a wide range of hosts, including rodents and humans. It targets different host cell types showing different intracellular lifestyles. S. Typhimurium colonizes differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5af088b4994e150404af94f7816eb4
https://hal-pasteur.archives-ouvertes.fr/pasteur-03263221