Artificial Intelligence-Powered Molecular Docking and Steered Molecular Dynamics for Accurate scFv Selection of Anti-CD30 Chimeric Antigen Receptors.

Autor: Martarelli N; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Capurro M; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Mansour G; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milano, Italy., Jahromi RV; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Stella A; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Rossi R; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Longetti E; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Bigerna B; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Gentili M; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Rosseto A; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Rossi R; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Cencini C; Department of Chemistry, Biology, and Biotechnologies, Via del Giochetto, University of Perugia, 06122 Perugia, Italy., Emiliani C; Department of Chemistry, Biology, and Biotechnologies, Via del Giochetto, University of Perugia, 06122 Perugia, Italy., Martino S; Department of Chemistry, Biology, and Biotechnologies, Via del Giochetto, University of Perugia, 06122 Perugia, Italy., Beeg M; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milano, Italy., Gobbi M; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milano, Italy., Tiacci E; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Falini B; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy., Morena F; Department of Chemistry, Biology, and Biotechnologies, Via del Giochetto, University of Perugia, 06122 Perugia, Italy., Perriello VM; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, 06132 Perugia, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 30; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 30.

CD47 expression in acute myeloid leukemia varies according to genotype.

Autor: Marra A; Institute of Hematology and Center for Haemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy; Department of Life Sciences, Imperial College London, South Kensington Campus, London, United Kingdom; Laboratory of Molecular Medicine and Biotechnology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy; Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome 00133., Akarca AU; Department of Pathology, University College London, London., Martino G; Institute of Hematology and Center for Haemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy; Pathology Unit, Azienda Ospedaliera 'Santa Maria' di Terni, Terni., Ramsay A; Department of Pathology, University College London, London., Ascani S; Pathology Unit, Azienda Ospedaliera 'Santa Maria' di Terni, Terni., Perriello VM; Institute of Hematology and Center for Haemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia., O'Nions J; Department of Haematology, University College London NHS Foundation Trust, London., Wilson AJ; Department of Haematology, University College London NHS Foundation Trust, London., Gupta R; Department of Haematology, University College London NHS Foundation Trust, London, United Kingdom; UCL Cancer Institute, University College London, London., Childerhouse A; Department of Pathology, University College London, London., Proctor I; Department of Pathology, University College London, London., Rodriguez-Justo M; Department of Pathology, University College London, London., Pomplun S; Department of Pathology, University College London, London., Martelli MP; Institute of Hematology and Center for Haemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia., Lo Celso C; Department of Life Sciences, Imperial College London, South Kensington Campus, London, United Kingdom; Sir Francis Crick Institute, London., Falini B; Institute of Hematology and Center for Haemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia., Marafioti T; Department of Pathology, University College London, London. t.marafioti@ucl.ac.uk.

Publikováno v: Haematologica [Haematologica] 2023 Dec 01; Vol. 108 (12), pp. 3491-3495. Date of Electronic Publication: 2023 Dec 01.

IL-3-zetakine combined with a CD33 costimulatory receptor as a dual CAR approach for safer and selective targeting of AML.

Autor: Perriello VM; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Rotiroti MC; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA., Pisani I; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Galimberti S; Center of Biostatistics for Clinical Epidemiology, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Alberti G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Pianigiani G; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Ciaurro V; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Marra A; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Sabino M; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Tini V; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Spinozzi G; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Mezzasoma F; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Morena F; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy., Martino S; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy., Salerno D; Department of Medicine and Surgery, BioNanoMedicine Center NANOMIB, University of Milano-Bicocca, Monza, Italy., Ashby JF; LUMICKS, Pilotenstraat 41, 1059 CH Amsterdam, The Netherlands., Wingham B; LUMICKS, Pilotenstraat 41, 1059 CH Amsterdam, The Netherlands., Serafini M; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Martelli MP; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Falini B; Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Biondi A; Pediatrics and Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Tettamanti S; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

Publikováno v: Blood advances [Blood Adv] 2023 Jun 27; Vol. 7 (12), pp. 2855-2871.

Overlapping features of therapy-related and de novo NPM1-mutated AML.

Autor: Othman J; Department of Medical and Molecular Genetics, King's College, London, United Kingdom.; Department of Haematology, Guy's and St Thomas Hospitals NHS Trust, London, United Kingdom., Meggendorfer M; MLL Munich Leukemia Laboratory, Munich, Germany., Tiacci E; Institute of Hematology and Center for Hemato-Oncology Research (CREO), Department of Medicine and Surgery, University and Hospital of Perugia, Perugia, Italy., Thiede C; University Hospital, Medical Clinic I, Dresden University of Technology, Dresden, Germany., Schlenk R; Department of Hematology/Oncology and NCT Trial Center, Heidelberg University Hospital, and German Cancer Research Center, Heidelberg, Germany., Dillon R; Department of Medical and Molecular Genetics, King's College, London, United Kingdom.; Department of Haematology, Guy's and St Thomas Hospitals NHS Trust, London, United Kingdom., Stasik S; University Hospital, Medical Clinic I, Dresden University of Technology, Dresden, Germany., Venanzi A; Institute of Hematology and Center for Hemato-Oncology Research (CREO), Department of Medicine and Surgery, University and Hospital of Perugia, Perugia, Italy., Bertoli S; Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France., Delabesse E; Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France., Dumas PY; Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., Pigneux A; Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., Bidet A; Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., Gilkes AF; Department of Hematology and Centre for Trials Research, School of Medicine, Cardiff University, Cardiff, United Kingdom., Thomas I; Department of Hematology and Centre for Trials Research, School of Medicine, Cardiff University, Cardiff, United Kingdom., Voso MT; Institute of Hematology, University of Tor Vergata, Rome, Italy., Rambaldi A; Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Brunetti L; Università Politecnica delle Marche, Ancona, Italy., Perriello VM; Institute of Hematology and Center for Hemato-Oncology Research (CREO), Department of Medicine and Surgery, University and Hospital of Perugia, Perugia, Italy., Andresen V; Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway., Gjertsen BT; Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway., Martelli MP; Institute of Hematology and Center for Hemato-Oncology Research (CREO), Department of Medicine and Surgery, University and Hospital of Perugia, Perugia, Italy., Récher C; Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France., Röllig C; University Hospital, Medical Clinic I, Dresden University of Technology, Dresden, Germany., Bornhäuser M; University Hospital, Medical Clinic I, Dresden University of Technology, Dresden, Germany., Serve H; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, Frankfurt, Germany., Müller-Tidow C; Department of Hematology/Oncology and NCT Trial Center, Heidelberg University Hospital, and German Cancer Research Center, Heidelberg, Germany., Baldus CD; Universitätsklinikum Schleswig-Holstein, Kiel, Germany., Haferlach T; MLL Munich Leukemia Laboratory, Munich, Germany., Russell N; Department of Haematology, Guy's and St Thomas Hospitals NHS Trust, London, United Kingdom.; Nottingham University, Nottingham, United Kingdom., Falini B; Institute of Hematology and Center for Hemato-Oncology Research (CREO), Department of Medicine and Surgery, University and Hospital of Perugia, Perugia, Italy.

Publikováno v: Blood [Blood] 2023 Apr 13; Vol. 141 (15), pp. 1846-1857.

CAR T cell-driven cerebrospinal fluid cytokine storm with confounding neurological picture in chemorefractory primary cardiac lymphoma.

Autor: Perriello VM; Institute of Hematology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Falini L; Institute of Hematology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Ruggeri L; Institute of Hematology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Innocente A; Institute of Hematology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Ballanti S; Institute of Hematology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Costa C; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Di Filippo M; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Gargaro M; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Fallarino F; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Falini B; Institute of Hematology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Publikováno v: American journal of hematology [Am J Hematol] 2023 Jan; Vol. 98 (1), pp. 212-219. Date of Electronic Publication: 2022 Nov 25.