MARVEL-minimising the emergence and dissemination of HIV-1 drug resistance in Portuguese-speaking African Countries (PALOP): low-cost portable NGS platform for HIV-1 surveillance in Africa

Autor: Cruz S. Sebastião, Marta Pingarilho, Jamila Bathy, Elizângela Bonfim, Katia Toancha, Mafalda N.S. Miranda, M Rosário O. Martins, Perpetua Gomes, Lazismino Lázaro, Isabel Pina-Araujo, Tacilta Nhampossa, Silvania Leal, Ana B. Abecasis, Victor Pimentel

Publikováno v: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-8 (2024)

Abstract Background HIV-1 infections remain a global public health concern. Scaled-up antiretroviral treatment (ART) is crucial for reducing morbidity and mortality related to HIV/AIDS. The emergence of drug-resistance mutations (DRMs) compromises vi

Externí odkaz: https://doaj.org/article/bf547478792047c1ba0a772b1b32a0ea

Sociodemographic, Clinical, and Behavioral Factors Associated with Sexual Transmitted Infection among HIV-1 Positive Migrants in Portugal: Are There Differences between Sexes?

Autor: Mafalda N. S. Miranda, Victor Pimentel, Jacqueline Graça, Sofia G. Seabra, Cruz S. Sebastião, António Diniz, Domitília Faria, Eugénio Teófilo, Fausto Roxo, Fernando Maltez, Isabel Germano, Joaquim Oliveira, José Ferreira, José Poças, Kamal Mansinho, Luís Mendão, Maria João Gonçalves, Margarida Mouro, Nuno Marques, Patrícia Pacheco, Paula Proença, Raquel Tavares, Ricardo Correia de Abreu, Rosário Serrão, Telo Faria, BESTHOPE Study Group, M. Rosário O. Martins, Perpétua Gomes, Ana B. Abecasis, Marta Pingarilho

Publikováno v: Pathogens, Vol 13, Iss 7, p 598 (2024)

Introduction: Sexually transmitted infections (STIs) continue to occur at high levels. According to the WHO, each year there are an estimated 374 million new infections with syphilis, gonorrhea, chlamydia, and trichomoniasis. STIs are associated with

Externí odkaz: https://doaj.org/article/e50e1e0fc42546399fdd4edd28e02706

Applying Next-Generation Sequencing to Track HIV-1 Drug Resistance Mutations Circulating in Portugal

Autor: Victor Pimentel, Marta Pingarilho, Cruz S. Sebastião, Mafalda Miranda, Fátima Gonçalves, Joaquim Cabanas, Inês Costa, Isabel Diogo, Sandra Fernandes, Olga Costa, Rita Corte-Real, M. Rosário O. Martins, Sofia G. Seabra, Ana B. Abecasis, Perpétua Gomes

Publikováno v: Viruses, Vol 16, Iss 4, p 622 (2024)

Background: The global scale-up of antiretroviral treatment (ART) offers significant health benefits by suppressing HIV-1 replication and increasing CD4 cell counts. However, incomplete viral suppression poses a potential threat for the emergence of

Externí odkaz: https://doaj.org/article/d6ab4e9be5ba4504afdad413f2d62f01

Management of HIV-2 resistance to antiretroviral therapy in a HIV-1/HIV-2/HBV co-infected patient

Autor: Margarida Cardoso, Joana Vasconcelos, Teresa Baptista, Isabel Diogo, Fátima Gonçalves, Kamal Mansinho, Perpétua Gomes

Publikováno v: AIDS Research and Therapy, Vol 18, Iss 1, Pp 1-4 (2021)

Abstract Background The current standard of care is to start antiretroviral therapy in all patients diagnosed with HIV-1, as for HIV-2 current DHHS guideline suggests ART for HIV-2 as soon as diagnosis is established, although this practice is not un

Externí odkaz: https://doaj.org/article/6d38f292aabb429da1517850ff278e88

Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Autor: Anita Y.M. Howe, Chaturaka Rodrigo, Evan B. Cunningham, Mark W. Douglas, Julia Dietz, Jason Grebely, Stephanie Popping, Javier Alejandro Sfalcin, Milosz Parczewski, Christoph Sarrazin, Adolfo de Salazar, Ana Fuentes, Murat Sayan, Josep Quer, Midori Kjellin, Hege Kileng, Orna Mor, Johan Lennerstrand, Slim Fourati, Velia Chiara Di Maio, Vladimir Chulanov, Jean-Michel Pawlotsky, P. Richard Harrigan, Francesca Ceccherini-Silberstein, Federico Garcia, Marianne Martinello, Gail Matthews, Fay Fabián Fernando, Juan I. Esteban, Beat Müllhaupt, Julian Schulze zur Wiesch, Peter Buggisch, Christoph Neumann-Haefelin, Thomas Berg, Christoph P. Berg, Jörn M. Schattenberg, Christophe Moreno, Rudolf Stauber, Andrew Lloyd, Gregory Dore, Tanya Applegate, Juan Ignacio, Damir Garcia-Cehic, Josep Gregori, Francisco Rodriguez-Frias, Ariadna Rando, Yael Gozlan, Mario Angelico, Massimo Andreoni, Sergio Babudieri, Ada Bertoli, Valeria Cento, Nicola Coppola, Antonio Craxì, Stefania Paolucci, Giustino Parruti, Caterina Pasquazzi, Carlo Federico Perno, Elisabetta Teti, C. Vironet, Anders Lannergård, Ann-Sofi Duberg, Soo Aleman, Tore Gutteberg, Alexandre Soulier, Aurélie Gourgeon, Stephane Chevaliez, Stanislas Pol, Fabrice Carrat, Dominique Salmon, Rolf Kaiser, Elena Knopes, Perpetua Gomes, Rob de Kneght, Bart Rijnders, Mario Poljak, Maja Lunar, Rafael Usubillaga, Carole Seguin_Devaux, Enoch Tay, Caroline Wilson, Dao Sen Wang, Jacob George, Jen Kok, Ana Belén Pérez, Natalia Chueca, Miguel García-Deltoro, Ana María Martínez-Sapiña, María Magdalena Lara-Pérez, Silvia García-Bujalance, Teresa Aldámiz-Echevarría, Francisco Jesús Vera-Méndez, Juan Antonio Pineda, Marta Casado, Juan Manuel Pascasio, Javier Salmerón, Juan Carlos Alados-Arboledas, Antonio Poyato, Francisco Téllez, Antonio Rivero-Juárez, Dolores Merino, María Jesús Vivancos-Gallego, José Miguel Rosales-Zábal, María Dolores Ocete, Miguel Ángel Simón, Pilar Rincón, Sergi Reus, Alberto De la Iglesia, Isabel García-Arata, Miguel Jiménez, Fernando Jiménez, José Hernández-Quero, Carlos Galera, Mohamed Omar Balghata, Joaquín Primo, Mar Masiá, Nuria Espinosa, Marcial Delgado, Miguel Ángel von-Wichmann, Antonio Collado, Jesús Santos, Carlos Mínguez, Felícitas Díaz-Flores, Elisa Fernández, Enrique Bernal, José De Juan, José Joaquín Antón, Mónica Vélez, Antonio Aguilera, Daniel Navarro, Juan Ignacio Arenas, Clotilde Fernández, María Dolores Espinosa, María José Ríos, Roberto Alonso, Carmen Hidalgo, Rosario Hernández, María Jesús Téllez, Francisco Javier Rodríguez, Pedro Antequera, Cristina Delgado, Patricia Martín, Javier Crespo, Berta Becerril, Oscar Pérez, Antonio García-Herola, José Montero, Carolina Freyre, Concepción Grau, Joaquin Cabezas, Miguel Jimenez, Manuel Alberto Macias Rodriguez, Cristina Quilez, Maria Rodriguez Pardo, Leopoldo Muñoz-Medina, Blanca Figueruela

Publikováno v: JHEP Reports, Vol 4, Iss 5, Pp 100462- (2022)

Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment opt

Externí odkaz: https://doaj.org/article/f2e6a1ce74794d3c98e6f58a4144688c