Zobrazeno 1 - 10
of 3 252
pro vyhledávání: '"Peroxisome Proliferator-Activated Receptor γ"'
Publikováno v:
Linchuang shenzangbing zazhi, Vol 24, Iss 11, Pp 930-937 (2024)
Objective To explore the effect and mechanism of astragalin （AG） in alleviating renal injury in diabetic kidney disease(DKD). Methods db/m and db/db mice aged 16 weeks were randomized into four groups of db/m, db/m+AG （5 mg/kg）, db/db and db/
Externí odkaz:
https://doaj.org/article/c845890ef9bd49efa3441fdf6ced5d0b
Publikováno v:
环境与职业医学, Vol 41, Iss 10, Pp 1167-1172 (2024)
BackgroundDi(2-ethylhexyl) phthalate (DEHP) is the highest consumed and the most widely used phthalic acid ester, their effects on lipid metabolism have attracted the attention of many scholars. However, the associated mechanism is still unclear.Obje
Externí odkaz:
https://doaj.org/article/96de5460983c41d596c3ca759479503e
Publikováno v:
Experimental Gerontology, Vol 194, Iss , Pp 112514- (2024)
Mitochondrial dysfunction is a prominent hallmark of Alzheimer's disease (AD). The transcriptional coactivator PPARγ coactivator 1 (PGC-1a) has been identified as a key regulator of mitochondrial biogenesis and function. However, the precise structu
Externí odkaz:
https://doaj.org/article/d9cea98039914a2d951166fe1df3d2ee
Autor:
Victor Sánchez, Anja Baumann, Annette Brandt, Maximilian F. Wodak, Raphaela Staltner, Ina Bergheim
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 785-800 (2024)
Background & Aims: Changes in phosphatidylcholine levels in the liver have been associated with the development of metabolic dysfunction–associated steatotic liver disease. Here, the effects of supplementing phosphatidylcholine on the development o
Externí odkaz:
https://doaj.org/article/b34220bf37ca4ca49085c4ef9b735bc0
Autor:
Longqing Zhang, Xi Tan, Fanhe Song, Danyang Li, Jiayi Wu, Shaojie Gao, Jia Sun, Daiqiang Liu, Yaqun Zhou, Wei Mei
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 3, Pp 687-696 (2024)
[INLINE:1] Activated G-protein-coupled receptor 39 (GPR39) has been shown to attenuate inflammation by interacting with sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). However, whether GPR39 attenuates n
Externí odkaz:
https://doaj.org/article/ca49ab450884405cab71986702925e8d
Autor:
Yaru Xie, Qian Yuan, Xinyi Cao, Yang Qiu, Jieyu Zeng, Yiling Cao, Yajuan Xie, Xianfang Meng, Kun Huang, Fan Yi, Chun Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 19, Pp n/a-n/a (2024)
Abstract Nuclear receptors (NRs) are important transcriptional factors that mediate autophagy, preventing podocyte injury and the progression of diabetic kidney disease (DKD). However, the role of nuclear receptor coactivators that are powerful enhan
Externí odkaz:
https://doaj.org/article/bc805486eb084bc5abcb2be83100bc37
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background Intervertebral disc degeneration (IDD) is the main pathogenesis of low back pain. MicroRNAs (miRNAs) have been found to exert regulatory function in IDD. This study aimed to investigate the effect and potential mechanism of miR-96
Externí odkaz:
https://doaj.org/article/fc251380ad9c4ac88842b32201b59ee5
Autor:
Hailan HE, Yuhui ZHOU, Jie CUI, Jiahui CAO, Mingming LIU, Bo GUAN, Yufan ZHOU, Hongli WANG, Heliang LIU
Publikováno v:
环境与职业医学, Vol 40, Iss 10, Pp 1201-1206 (2023)
BackgroundThe pathogenesis of silicosis is complex and treatment methods are limited. SiO2-induced increase of transforming growth factor-β1 (TGF-β1) can activate fibroblasts to promote collagen deposition, ultimately leading to fibrosis. Previous
Externí odkaz:
https://doaj.org/article/1bea883004944aaf82d7cdb1a7db0dac
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 9, Pp 1369-1374 (2023)
Objective To explore the analgesic effect and underlying mechanisms of dexmedetomidine(DEX) with spared nerve injury(SNI) rat model. Methods Forty-eight SD rats were randomly divided into control group, SNI group, DEX group and DEX+GW9662 group, with
Externí odkaz:
https://doaj.org/article/0ec12fcbe40c448e837536c24f77a26a
Autor:
Yu Li, Zhong-Hao Zhang, Shao-Ling Huang, Zhong-Bao Yue, Xue-Song Yin, Zi-Qi Feng, Xu-Guang Zhang, Guo-Li Song
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 8, Pp 5253-5265 (2023)
ABSTRACT: Whey protein powder (PP), which is mainly derived from bovine milk, is rich in milk fat globule membrane (MFGM). The MGFM has been shown to play a role in promoting neuronal development and cognition in the infant brain. However, its role i
Externí odkaz:
https://doaj.org/article/63426eecb57345cb87f34cffdfbaa0a8