Výsledky vyhledávání

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Autor: Lazar, AJ, McLellan, MD, Bailey, MH, Miller, CA, Appelbaum, EL, Cordes, MG, Fronick, CC, Fulton, LA, Fulton, RS, Mardis, ER, Schmidt, HK, Wong, W, Wilson, RK, Yellapantula, V, Radenbaugh, AJ, Hoadley, KA, Hayes, DN, Parker, JS, Wilkerson, MD, Auman, JT, Balu, S, Bodenheimer, T, Hoyle, AP, Jefferys, SR, Jones, CD, Lehmann, K-V, Meng, S, Mieczkowski, PA, Mose, LE, Perou, CM, Roach, J, Senbabaoglu, Y, Shi, Y, Simons, JV, Skelly, T, Soloway, MG, Tan, D, Veluvolu, U, Davis, IJ, Hepperla, AJ, Brohl, AS, Kasaian, K, Mungall, K, Sadeghi, S, Barthel, FP, Verhaak, R, Hu, X, Chibon, F, Cherniack, AD, Shih, J, Beroukhim, R, Meyerson, M, Cibulskis, C, Gabriel, SB, Saksena, G, Schumacher, SE, Gao, Q, Wyczalkowski, M, Bowlby, R, Robertson, AG, Ally, A, Balasundaram, M, Brooks, D, Carlsen, R, Chuah, E, Dhalla, N, Holt, RA, Jones, SJM, Lee, D, Li, I, Ma, Y, Marra, MA, Mayo, M, Moore, RA, Mungall, AJ, Schein, JE, Sipahimalani, P, Tam, A, Thiessen, N, Wong, T, Danilova, L, Cope, L, Baylin, SB, Bootwalla, MS, Lai, PH, Laird, PW, Maglinte, DT, Van Den Berg, DJ, Weisenberger, DJ, Wrangle, J, Drill, E, Shen, R, Iype, L, Reynolds, SM, Shmulevich, I, Yau, C, Armenia, J, Liu, EM, Benz, C, Pastore, A, Sanchez-Vega, F, Schultz, N, Akbani, R, Hegde, AM, Liu, W, Lu, Y, Mills, GB, Weinstein, JN, Roszik, J, Anur, P, Spellman, P, Abeshouse, A, Chen, H-W, Gao, J, Heins, Z, Kundra, R, Larsson, E, Ochoa, A, Sander, C, Socci, N, Zhang, H, Noble, MS, Heiman, DI, Kim, J, Chin, L, Getz, G, Cho, J, Defreitas, T, Frazer, S, Gehlenborg, N, Lawrence, MS, Lin, P, Meier, S, Voet, D, Byers, L, Diao, L, Gay, CM, Wang, J, Newton, Y, Cooper, LAD, Gutman, DA, Lee, S, Nalisnik, M, Bowen, J, Gastier-Foster, JM, Gerken, M, Helsel, C, Hobensack, S, Leraas, KM, Lichtenberg, TM, Ramirez, NC, Wise, L, Zmuda, E, Anderson, ML, Castro, P, Ittmann, M, Gordienko, E, Paklina, O, Setdikova, G, Raut, CP, Karlan, BY, Lester, J, Belyaev, D, Fulidou, V, Potapova, O, Voronina, O, Demetri, GD, Ramalingam, SS, Behera, M, Delman, K, Owonikoko, TK, Sica, GL, Boyd, J, Magliocco, A, Salner, A, Bennett, J, Iacocca, M, Swanson, P, Dottino, P, Kalir, T, Pereira, E, Akeredolu, T, Crain, D, Curley, E, Gardner, J, Mallery, D, Morris, S, Paulauskis, J, Penny, R, Shelton, C, Shelton, T, Thompson, E, Hoon, DB, Parfitt, J, Birrer, M, Karseladze, A, Mariamidze, A, Dao, F, Levine, DA, Olvera, N, Maki, RG, Bartlett, J, Eschbacher, J, Dubina, M, Mozgovoy, E, Fedosenko, K, Manikhas, G, Sekhon, H, Ramirez, N, Ingram, DR, Torres, KE, DiSaia, P, Godwin, AK, Godwin, EM, Kuo, H, Madan, R, Reilly, C, Adebamowo, C, Adebamowo, SN, Bocklage, T, Higgins, K, Martinez, C, Boice, L, Grilley-Olson, JE, Huang, M, Perou, AH, Thorne, LB, Rathmell, WK, Gutmann, DH, Singer, S, Chudamani, S, Liu, J, Lolla, L, Naresh, R, Pihl, T, Sun, Q, Wan, Y, Wu, Y, Felau, I, Zenklusen, JC, Demchok, JA, Ferguson, ML, Hutter, CM, Sofia, HJ, Tarnuzzer, R, Wang, Z, Yang, L, Zhang, JJ, Demicco, EG, Doyle, LA, Hornick, JL, Rubin, BP, de Rijn, MV, Baker, L, Riedel, RF, Ding, L, Ladanyi, M, Novak, JE, Van Tine, BA, Davis, LE, Grilley-Olsen, JE, Pollock, RE, Jones, KB, Martignetti, JA, Tong, P, Network, CGAR

Publikováno v: Lazar, AJ; McLellan, MD; Bailey, MH; Miller, CA; Appelbaum, EL; Cordes, MG; et al.(2017). Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. CELL, 171(4), 950-+. doi: 10.1016/j.cell.2017.10.014. UCLA: Retrieved from: http://www.escholarship.org/uc/item/47j3z4n7

Summary Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights int

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Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study

Autor: Martin M, Brase JC, Ruiz A, Prat A, Kronenwett R, Calvo L, Petry C, Bernard PS, Ruiz-Borrego M, Weber KE, Rodriguez CA, Alvarez IM, Segui MA, Perou CM, Casas M, Carrasco E, Caballero R, Rodriguez-Lescure A

Publikováno v: BREAST CANCER RESEARCH AND TREATMENT
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

There are several prognostic multigene-based tests for managing breast cancer (BC), but limited data comparing them in the same cohort. We compared the prognostic performance of the EndoPredict (EP) test (standardized for pathology laboratory) with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::212e9e91ca578c7aafe981ce944b6154
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2359

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Comprehensive genomic characterization of head and neck squamous cell carcinomas

Autor: Lawrence, MS, Sougnez, C, Lichtenstein, L, Cibulskis, K, Lander, E, Gabriel, SB, Getz, G, Ally, A, Balasundaram, M, Birol, I, Bowlby, R, Brooks, D, Butterfield, YSN, Carlsen, R, Cheng, D, Chu, A, Dhalla, N, Guin, R, Holt, RA, Jones, SJM, Lee, D, Li, HI, Marra, MA, Mayo, M, Moore, RA, Mungall, AJ, Robertson, AG, Schein, JE, Sipahimalani, P, Tam, A, Thiessen, N, Wong, T, Protopopov, A, Santoso, N, Lee, S, Parfenov, M, Zhang, J, Mahadeshwar, HS, Tang, J, Ren, X, Seth, S, Haseley, P, Zeng, D, Yang, L, Xu, AW, Song, X, Pantazi, A, Bristow, CA, Hadjipanayis, A, Seidman, J, Chin, L, Park, PJ, Kucherlapati, R, Akbani, R, Casasent, T, Liu, W, Lu, Y, Mills, G, Motter, T, Weinstein, J, Diao, L, Wang, J, Hong Fan, Y, Liu, J, Wang, K, Auman, JT, Balu, S, Bodenheimer, T, Buda, E, Hayes, DN, Hoadley, KA, Hoyle, AP, Jefferys, SR, Jones, CD, Kimes, PK, Liu, Y, Marron, JS, Meng, S, Mieczkowski, PA, Mose, LE, Parker, JS, Perou, CM, Prins, JF, Roach, J, Shi, Y, Simons, JV, Singh, D, Soloway, MG, Tan, D, Veluvolu, U, Walter, V, Waring, S, Wilkerson, MD, Wu, J

Publikováno v: Lawrence, MS; Sougnez, C; Lichtenstein, L; Cibulskis, K; Lander, E; Gabriel, SB; et al.(2015). Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature, 517(7536), 576-582. doi: 10.1038/nature14129. UCSF: Retrieved from: http://www.escholarship.org/uc/item/91s7f5c0

© 2015 Macmillan Publishers Limited. All rights reserved. The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomaviru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::052ed168d3419706b97ca9c05ff6035d
http://www.escholarship.org/uc/item/91s7f5c0

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Integrated genomic characterization of endometrial carcinoma

Autor: Getz, G, Gabriel, SB, Cibulskis, K, Lander, E, Sivachenko, A, Sougnez, C, Lawrence, M, Kandoth, C, Dooling, D, Fulton, R, Fulton, L, Kalicki-Veizer, J, McLellan, MD, O'Laughlin, M, Schmidt, H, Wilson, RK, Ye, K, Li, D, Ally, A, Balasundaram, M, Birol, I, Butterfield, YSN, Carlsen, R, Carter, C, Chu, A, Chuah, E, Chun, HJE, Dhalla, N, Guin, R, Hirst, C, Holt, RA, Jones, SJM, Lee, D, Li, HI, Marra, MA, Mayo, M, Moore, RA, Mungall, AJ, Plettner, P, Schein, JE, Sipahimalani, P, Tam, A, Varhol, RJ, Gordon Robertson, A, Cherniack, AD, Pashtan, I, Saksena, G, Onofrio, RC, Schumacher, SE, Tabak, B, Carter, SL, Hernandez, B, Gentry, J, Salvesen, HB, Ardlie, K, Winckler, W, Beroukhim, R, Meyerson, M, Hadjipanayis, A, Lee, S, Mahadeshwar, HS, Park, P, Protopopov, A, Ren, X, Seth, S, Song, X, Tang, J, Xi, R, Yang, L, Dong, Z, Kucherlapati, R, Chin, L, Zhang, J, Todd Auman, J, Balu, S, Bodenheimer, T, Buda, E, Neil Hayes, D, Hoyle, AP, Jefferys, SR, Jones, CD, Meng, S, Mieczkowski, PA, Mose, LE, Parker, JS, Perou, CM

Publikováno v: Getz, G; Gabriel, SB; Cibulskis, K; Lander, E; Sivachenko, A; Sougnez, C; et al.(2013). Integrated genomic characterization of endometrial carcinoma. Nature, 497(7447), 67-73. doi: 10.1038/nature12113. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2wf5f3w7

We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array-and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::f0a405078d8b35923a004982aa487fc9
http://www.escholarship.org/uc/item/2wf5f3w7

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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

Autor: Haiman, CA, Chen, GK, Vachon, CM, Canzian, F, Dunning, A, Millikan, RC, Wang, X, Ademuyiwa, F, Ahmed, S, Ambrosone, CB, Baglietto, L, Balleine, R, Bandera, EV, Beckmann, MW, Berg, CD, Bernstein, L, Blomqvist, C, Blot, WJ, Brauch, H, Buring, JE, Carey, LA, Carpenter, JE, Chang-Claude, J, Chanock, SJ, Chasman, DI, Clarke, CL, Cox, A, Cross, SS, Deming, SL, Diasio, RB, Dimopoulos, AM, Driver, WR, Duennebier, T, Durcan, L, Eccles, D, Edlund, CK, Ekici, AB, Fasching, PA, Feigelson, HS, Flesch-Janys, D, Fostira, F, Foersti, A, Fountzilas, G, Gerty, SM, Giles, GG, Godwin, AK, Goodfellow, P, Graham, N, Greco, D, Hamann, U, Hankinson, SE, Hartmann, A, Hein, R, Heinz, J, Holbrook, A, Hoover, RN, Hu, JJ, Hunter, DJ, Ingles, SA, Irwanto, A, Ivanovich, J, John, EM, Johnson, N, Jukkola-Vuorinen, A, Kaaks, R, Ko, Y-D, Kolonel, LN, Konstantopoulou, I, Kosma, V-M, Kulkarni, S, Lambrechts, D, Lee, AM, Le Marchand, L, Lesnick, T, Liu, J, Lindstrom, S, Mannermaa, A, Margolin, S, Martin, NG, Miron, P, Montgomery, GW, Nevanlinna, H, Nickels, S, Nyante, S, Olswold, C, Palmer, J, Pathak, H, Pectasides, D, Perou, CM, Peto, J, Pharoah, PDP, Pooler, LC, Press, MF, Pylkas, K, Rebbeck, TR, Rodriguez-Gil, JL, Rosenberg, L, Ross, E, Ruediger, T, Silva, IDS, Sawyer, E, Schmidt, MK, Schulz-Wendtland, R, Schumacher, F, Severi, G, Sheng, X, Signorello, LB, Sinn, H-P, Stevens, KN, Southey, MC, Tapper, WJ, Tomlinson, I, Hogervorst, FBL, Wauters, E, Weaver, J, Wildiers, H, Winqvist, R, Van Den Berg, D, Wan, P, Xia, LY, Yannoukakos, D, Zheng, W, Ziegler, RG, Siddiq, A, Slager, SL, Stram, DO, Easton, D, Kraft, P, Henderson, BE, Couch, FJ, Gene, EIBC

Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::796ff9b1c2ca4f187b1d7d9656f663a7
https://eprints.whiterose.ac.uk/152414/1/nihms353821.pdf

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Integrated genomic analyses of ovarian carcinoma

Autor: Bell, D, Berchuck, A, Birrer, M, Chien, J, Cramer, DW, Dao, F, Dhir, R, DiSaia, P, Gabra, H, Glenn, P, Godwin, AK, Triche, T, Berman, BP, Van den Berg, DJ, Buckley, J, Baylin, SB, Zhang, J, Spellman, PT, Purdom, E, Iacocca, M, Shelton, T, Voet, D, Neuvial, P, Bengtsson, H, Jakkula, LR, Durinck, S, Han, J, Dorton, S, Marr, H, Zhang, H, Choi, YG, Wang, V, Wilkinson, J, Nguyen, H, Wang, NJ, Imielinski, M, Ngai, J, Conboy, JG, Parvin, B, Feiler, HS, Speed, TP, Gray, JW, Wu, CJ, Bloom, T, Levine, DA, Li, L, Socci, ND, Liang, Y, Taylor, BS, Kalloger, S, Schultz, N, Borsu, L, Lash, AE, Brennan, C, Ardlie, K, Viale, A, Shukla, S, Grimm, D, Sander, C, Ladanyi, M, Hoadley, KA, Meng, S, Du, Y, Karlan, BY, Shi, Y, Fennell, T, Cibulskis, K, Lawrence, MS, Meyerson, M, Hatfield, M, Mills, GB, Sivachenko, A, Jing, R, Park, RW, Liu, Y, Park, PJ, Ramos, AH, Noble, M, Chin, L, Carter, H, Kim, D, Morris, S, Winckler, W, Karchin, R, Morrison, C, Baldwin, J, Korkola, JE, Yena, P, Heiser, LM, Getz, G, Cho, RJ, Hu, Z, Gabriel, S, Mutch, D, Cerami, E, Rhodes, P, Olshen, A, Verhaak, RGW, Lander, ES, Reva, B, Antipin, Y, Shen, R, Olvera, N, Mankoo, P, Sheridan, R, Ciriello, G, Sherman, M, Chang, WK, Bernanke, JA, Hayes, DN, Carter, SL, Haussler, D, Orsulic, S, Benz, CC, Paulauskis, J, Stuart, JM, Zhang, N, Benz, SC, Sanborn, JZ, Vaske, CJ, Mermel, CH, Zhu, J, Szeto, C, Scott, GK, Yau, C, Rabeno, B, Ding, L, Park, K, Balu, S, Perou, CM, Saksena, G, Wilkerson, MD, Millis, S, Kahn, A, Turman, YJ, Fulton, RS, Onofrio, RC, Greene, JM, Sfeir, R, Jensen, MA, Chen, J, Whitmore, J, Alonso, S, Jordan, J, Chu, A, Rader, JS, Koboldt, DC, Zang, D, Gross, J, Barker, A, Compton, C, Eley, G, Ferguson, M, Fielding, P, Gerhard, DS, Myles, R, McLellan, MD, Schaefer, C, Helms, EB, Shaw, KRM, Sikic, BI, Vaught, J, Vockley, JB, Good, PJ, Guyer, MS, Ozenberger, B, Wylie, T, Peterson, J, Thomson, E, Smith-McCune, K, Sood, AK, Bowtell, D, Hubbard, D, Penny, R, Testa, JR, Chang, K, Walker, J, Dinh, HH, Drummond, JA, Fowler, G, Zhou, X, Gunaratne, P, Hawes, AC, Kovar, CL, Lewis, LR, Gupta, S, Morgan, MB, O'Laughlin, M, Newsham, IF, Santibanez, J, Reid, JG, Trevino, LR, Wu, J, Wu, Y-Q, Wang, M, Muzny, DM, Wheeler, DA, Gibbs, RA, Crenshaw, A, Sivachenko, AY, Topal, MD, Sougnez, C, Dooling, DJ, Fulton, L, Akbani, R, Abbott, R, Dees, ND, Zhang, Q, Kandoth, C, Wendl, M, Schierding, W, Shen, D, Harris, CC, Baggerly, KA, Schmidt, H, Wilson, RK, Kalicki, J, Delehaunty, KD, Fronick, CC, Demeter, R, Cook, L, Wallis, JW, Lin, L, Magrini, VJ, Yung, WK, Hodges, JS, Protopopov, A, Eldred, JM, Smith, SM, Pohl, CS, Vandin, F, Raphael, BJ, Weinstock, GM, Mardis, R, Kim, TM, Hartmann, L, Perna, I, Xiao, Y, Ren, G, Sathiamoorthy, N, Petrelli, N, Lee, E, Kucherlapati, R, Absher, DM, Huang, M, Waite, L, Sherlock, G, Brooks, JD, Li, JZ, Weinstein, JN, Xu, J, Myers, RM, Laird, PW, Cope, L, Herman, JG, Shen, H, Huntsman, DG, Weisenberger, DJ, Noushmehr, H, Pan, F

Publikováno v: PMC
Nature

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a525d87ace4cdaf0efff1d814bd60d0
http://hdl.handle.net/1721.1/74091

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Akademický článek

A Core MYC Gene Expression Signature is prominent in basal-like breast cancer but only partially overlaps the Core Serum Response.

Autor: Frengen, Eirik, Cowling, V, Chandriani, S, Pendergrass, SA, Perou, CM, Whitfield, ML, Cole, MD

Publikováno v: Frengen, Eirik, , , , , , Cowling, V, , , , , , Chandriani, S, , , , , , Pendergrass, SA, , , , , , Perou, CM, , , , , , Whitfield, ML, , , , , , Cole, MD, , , , , , . A Core MYC Gene Expression Signature is prominent in basal-like breast cancer but only partially overlaps the Core Serum Response.. PLoS ONE
PLoS ONE

Externí odkaz: http://hdl.handle.net/10852/28163
https://www.duo.uio.no/bitstream/handle/10852/28163/1/PLoS_frengen.pdf

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