IRF5 Is a Specific Marker of Inflammatory MacrophagesIn Vivo

Autor: Weiss, M, Blazek, K, Byrne, AJ, Perocheau, DP, Udalova, IA

Publikováno v: Mediators of Inflammation, Vol 2013 (2013)
Mediators of Inflammation

Macrophages are an integral part of the innate immune system and key players in pathogen clearance and tissue remodelling. Both functions are accomplished by a pivotal network of different macrophage subtypes, including proinflammatory M1 and anti-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13d430e34887465ac2a8bc9502ba1d6
https://doi.org/10.1155/2013/245804

Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus Vectors.

Autor: Westhaus A; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Cabanes-Creus M; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Dilworth KL; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Zhu E; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Salas Gómez D; Gene Therapy and Regulation of Gene Expression Department, IdiSNA, Instituto de Investigación Sanitaria de Navarra, Universidad de Navarra, CIMA, Pamplona, Spain., Navarro RG; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Amaya AK; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Scott S; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Sydney, Australia., Kwiatek M; Military Institute of Hygiene and Epidemiology, The Biological Threats Identification and Countermeasure Centre, Puławy, Poland., McCorkindale AL; Inventia Life Science Pty Ltd., Sydney, Australia., Hayman TE; Inventia Life Science Pty Ltd., Sydney, Australia., Frahm S; Stem Cell Technology Platform, Max Delbrück Centrum for Molecular Medicine, Berlin, Germany., Perocheau DP; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; Metabolic Medicine Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.; National Institute of Health Research Great Ormond Street Hospital Biomedical Research Centre, London, United Kingdom., Tran BM; Department of Infectious Diseases, Melbourne Medical School, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Vincan E; Department of Infectious Diseases, Melbourne Medical School, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Curtin Medical School, Curtin University, Perth, Australia., Wong SL; Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, Australia.; School of Biomedical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia., Waters SA; Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, Australia.; School of Biomedical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.; Department of Respiratory Medicine, Sydney Children's Hospital, Faculty of Medicine, University of New South Wales, Sydney, Australia., Riddiough GE; Department of Infectious Diseases, Melbourne Medical School, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Surgery, Austin Health Precinct, The University of Melbourne, Austin Health, Heidelberg, Australia., Perini MV; Department of Surgery, Austin Health Precinct, The University of Melbourne, Austin Health, Heidelberg, Australia., Wilson LOW; Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Sydney, Australia.; Applied BioSciences, Faculty of Science and Engineering, Macquarie University, Sydney, Australia., Baruteau J; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; Metabolic Medicine Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.; National Institute of Health Research Great Ormond Street Hospital Biomedical Research Centre, London, United Kingdom., Diecke S; Stem Cell Technology Platform, Max Delbrück Centrum for Molecular Medicine, Berlin, Germany., González-Aseguinolaza G; Gene Therapy and Regulation of Gene Expression Department, IdiSNA, Instituto de Investigación Sanitaria de Navarra, Universidad de Navarra, CIMA, Pamplona, Spain., Santilli G; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Thrasher AJ; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Alexander IE; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia., Lisowski L; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Vector and Genome Engineering Facility, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine, Warszawa, Poland.

Publikováno v: Human gene therapy [Hum Gene Ther] 2023 Apr; Vol. 34 (7-8), pp. 273-288.

Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.

Autor: Soria LR; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Gurung S; UCL Great Ormond Street Institute of Child Health, London, UK., De Sabbata G; International Centre for Genetic Engineering and Biotechnology, Trieste, Italy., Perocheau DP; UCL Great Ormond Street Institute of Child Health, London, UK., De Angelis A; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Bruno G; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Polishchuk E; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Paris D; Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy., Cuomo P; Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy., Motta A; Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy., Orford M; UCL Great Ormond Street Institute of Child Health, London, UK., Khalil Y; UCL Great Ormond Street Institute of Child Health, London, UK., Eaton S; UCL Great Ormond Street Institute of Child Health, London, UK., Mills PB; UCL Great Ormond Street Institute of Child Health, London, UK., Waddington SN; UCL Great Ormond Street Institute of Child Health, London, UK.; Wits/SAMRC Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Settembre C; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Muro AF; International Centre for Genetic Engineering and Biotechnology, Trieste, Italy., Baruteau J; UCL Great Ormond Street Institute of Child Health, London, UK.; Metabolic Medicine Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Brunetti-Pierri N; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.; Department of Translational Medicine, Federico II University, Naples, Italy.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2021 Feb 05; Vol. 13 (2), pp. e13158. Date of Electronic Publication: 2020 Dec 28.

An In Vitro Whole-Organ Liver Engineering for Testing of Genetic Therapies.

Autor: Lorvellec M; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Pellegata AF; Developmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Maestri A; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Turchetta C; Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta,' Politecnico di Milano, Milan 20133, Italy., Alvarez Mediavilla E; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Shibuya S; Developmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Jones B; Developmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Scottoni F; Developmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Perocheau DP; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Cozmescu AC; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London WC1N 1EH, UK., Delhove JM; Robinson Research Institute, University of Adelaide, Adelaide, SA, 5006, Australia., Kysh D; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK., Gjinovci A; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK., Counsell JR; Dubowitz Neuromuscular Centre, Molecular Neurosciences Section, Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK., Heywood WE; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Mills K; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., McKay TR; Centre for Bioscience, Manchester Metropolitan University, Manchester M1 5GD, UK., De Coppi P; Developmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Gissen P; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.

Publikováno v: IScience [iScience] 2020 Nov 13; Vol. 23 (12), pp. 101808. Date of Electronic Publication: 2020 Nov 13 (Print Publication: 2020).

Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort.

Autor: Perocheau DP; 1 Genetics and Genomic Medicine Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; 2 Gene Transfer Technology Group, Institute for Women's Health, University College London, London, United Kingdom., Cunningham S; 3 Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney and Sydney Children's Hospital Network, Westmead, Australia., Lee J; 1 Genetics and Genomic Medicine Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; 2 Gene Transfer Technology Group, Institute for Women's Health, University College London, London, United Kingdom., Antinao Diaz J; 2 Gene Transfer Technology Group, Institute for Women's Health, University College London, London, United Kingdom., Waddington SN; 2 Gene Transfer Technology Group, Institute for Women's Health, University College London, London, United Kingdom.; 4 Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa., Gilmour K; 5 Clinical Immunology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Eaglestone S; 6 Translational Research Office, University College London, London, United Kingdom., Lisowski L; 3 Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney and Sydney Children's Hospital Network, Westmead, Australia.; 7 Translational Vectorology Group, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, Australia.; 8 Military Institute of Hygiene and Epidemiology, The Biological Threats Identification and Countermeasure Centre, Puławy, Poland., Thrasher AJ; 5 Clinical Immunology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.; 9 Infection, Immunity and Inflammation Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Alexander IE; 3 Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney and Sydney Children's Hospital Network, Westmead, Australia.; 10 Discipline of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Westmead, Australia., Gissen P; 1 Genetics and Genomic Medicine Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; 11 MRC Laboratory for Molecular Biology, University College London, London, United Kingdom.; 12 Metabolic Medicine Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Baruteau J; 1 Genetics and Genomic Medicine Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; 2 Gene Transfer Technology Group, Institute for Women's Health, University College London, London, United Kingdom.; 12 Metabolic Medicine Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Publikováno v: Human gene therapy [Hum Gene Ther] 2019 Jan; Vol. 30 (1), pp. 79-87. Date of Electronic Publication: 2018 Oct 19.