Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pernille Wismann"'
Autor:
Mette Simone Aae Madsen, Jacob Bak Holm, Albert Pallejà, Pernille Wismann, Katrine Fabricius, Kristoffer Rigbolt, Martin Mikkelsen, Morten Sommer, Jacob Jelsing, Henrik Bjørn Nielsen, Niels Vrang, Henrik H. Hansen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Enteroendocrine L-cell derived peptide hormones, notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), have become important targets in the treatment of type 2 diabetes, obesity and intestinal diseases. As gut microbia
Externí odkaz:
https://doaj.org/article/7cc76709e4214ac29b3c51f8c12f05a0
Autor:
Pernille Wismann, Pernille Barkholt, Thomas Secher, Niels Vrang, Henrik B. Hansen, Palle Bekker Jeppesen, Laurie L. Baggio, Jacqueline A. Koehler, Daniel J. Drucker, Darleen A. Sandoval, Jacob Jelsing
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 681-692 (2017)
Objective: The prevalence of obesity and related co-morbidities is reaching pandemic proportions. Today, the most effective obesity treatments are glucagon-like peptide 1 (GLP-1) analogs and bariatric surgery. Interestingly, both intervention paradig
Externí odkaz:
https://doaj.org/article/cfc80da140484ad69afe224da8fbaaee
Autor:
Keld Fosgerau, Palle Jeppesen, Gitte Hansen, Karin Mannerstedt, Søren L. Pedersen, Pernille Wismann, Niels Vrang, Jacob Jelsing, Philip J. Pedersen
Publikováno v:
Physiology & Behavior. 192:72-81
Aim Analogues of several gastrointestinal peptide hormones have been developed into effective medicines for treatment of diseases such as type 2 diabetes mellitus (T2DM), obesity and short bowel syndrome (SBS). In this study, we aimed to explore whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a7a52918830a2e56ad46946fc5c742
https://doi.org/10.1016/j.physbeh.2018.03.004
https://doi.org/10.1016/j.physbeh.2018.03.004
Autor:
Knud J. Jensen, Søren Blok van Witteloostuijn, Søren L. Pedersen, Mikkel B. Thygesen, Manuel C. Martos-Maldonado, Jacob Jelsing, Niels Vrang, Kasper K. Sørensen, Pernille Wismann, Esben M. Bech
Publikováno v:
Journal of Medicinal Chemistry. 60:7434-7446
Noncovalent binding of biopharmaceuticals to human serum albumin protects against enzymatic degradation and renal clearance. Herein, we investigated the effect of mono- or divalent small-molecule albumin binders for half-life extension of peptides. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a0fb5a9e969193c0073c64a97f294d
https://doi.org/10.1021/acs.jmedchem.7b00787
https://doi.org/10.1021/acs.jmedchem.7b00787
Autor:
Søren Blok van Witteloostuijn, Søren L. Pedersen, Mikkel B. Thygesen, Esben M. Bech, Jacob Jelsing, Knud J. Jensen, Niels Vrang, Karin Mannerstedt, Pernille Wismann
Publikováno v:
Molecular Pharmaceutics. 14:193-205
Novel principles for optimizing the properties of peptide-based drugs are needed in order to leverage their full pharmacological potential. We present the design, synthesis, and evaluation of a library of neoglycolipidated glucagon-like peptide 1 (GL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fff855fea81c7e76738fca4e81496b
https://doi.org/10.1021/acs.molpharmaceut.6b00787
https://doi.org/10.1021/acs.molpharmaceut.6b00787
Autor:
Soumitra S. Ghosh, Pernille Wismann, Francesco Rubino, Harith Rajagopalan, Kristoffer T.G. Rigbolt, David G. Maggs
Publikováno v:
Diabetes. 67
Westernized diet (WD; high fat and sugar) induces an insulin resistant state associated with obesity and type 2 diabetes (T2D). Duodenal exclusion surgery in obese T2D patients implicates the duodenum as a key GI region involved in insulin resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2442e3881a1bd2c0c60a099cd4b7e5
https://doi.org/10.2337/db18-1900-p
https://doi.org/10.2337/db18-1900-p
Autor:
Sanne Moeller Knudsen, Pernille Wismann, Maria Waldhoer, Sarah Norklit Roed, Helle Iversen, Anne Cathrine Nøhr, Hans Bräuner-Osborne
Publikováno v:
Journal of Biological Chemistry. 290:1233-1243
The signaling capacity of seven-transmembrane/G-protein-coupled receptors (7TM/GPCRs) can be regulated through ligand-mediated receptor trafficking. Classically, the recycling of internalized receptors is associated with resensitization, whereas rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9d576d873250b1a880111c8d0caedf
https://doi.org/10.1074/jbc.m114.592436
https://doi.org/10.1074/jbc.m114.592436
Autor:
Henrik B. Hansen, Darleen A. Sandoval, Palle Jeppesen, Thomas Secher, Niels Vrang, Daniel J. Drucker, Jacob Jelsing, Pernille Barkholt, Pernille Wismann, Laurie L. Baggio, Jacqueline A. Koehler
Publikováno v:
Molecular Metabolism
Wismann, P, Barkholt, P, Secher, T, Vrang, N, Hansen, H B, Jeppesen, P B, Baggio, L L, Koehler, J A, Drucker, D J, Sandoval, D A & Jelsing, J 2017, ' The endogenous preproglucagon system is not essential for gut growth homeostasis in mice ', Molecular Metabolism, vol. 6, no. 7, pp. 681-692 . https://doi.org/10.1016/j.molmet.2017.04.007
Molecular Metabolism, Vol 6, Iss 7, Pp 681-692 (2017)
Wismann, P, Barkholt, P, Secher, T, Vrang, N, Hansen, H B, Jeppesen, P B, Baggio, L L, Koehler, J A, Drucker, D J, Sandoval, D A & Jelsing, J 2017, ' The endogenous preproglucagon system is not essential for gut growth homeostasis in mice ', Molecular Metabolism, vol. 6, no. 7, pp. 681-692 . https://doi.org/10.1016/j.molmet.2017.04.007
Molecular Metabolism, Vol 6, Iss 7, Pp 681-692 (2017)
Objective The prevalence of obesity and related co-morbidities is reaching pandemic proportions. Today, the most effective obesity treatments are glucagon-like peptide 1 (GLP-1) analogs and bariatric surgery. Interestingly, both intervention paradigm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec378023ad8e064423f053730f6f4f2
https://pubmed.ncbi.nlm.nih.gov/28702324
https://pubmed.ncbi.nlm.nih.gov/28702324
Autor:
Helle Iversen, Nikolaj Kulahin, Hans Bräuner-Osborne, Sarah Noerklit Roed, Karen Arevad Cappelen, Anna Secher, Janne Lehtonen, Jesper Mosolff Mathiesen, Lauge Schäffer, Christina Rye Underwood, Maria Waldhoer, Jacob Hecksher-Soerensen, Jennifer L. Whistler, Pernille Wismann, Sanne Moeller Knudsen
Publikováno v:
Molecular and Cellular Endocrinology. 382:938-949
The glucagon-like peptide-1 incretin receptor (GLP-1R) of family B G protein-coupled receptors (GPCRs) is a major drug target in type-2-diabetes due to its regulatory effect on post-prandial blood-glucose levels. The mechanism(s) controlling GLP-1R m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63c12a6cd377b61f8ed921855ac1fd2
https://doi.org/10.1016/j.mce.2013.11.010
https://doi.org/10.1016/j.mce.2013.11.010