The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

Autor: Pernille Wismann, Pernille Barkholt, Thomas Secher, Niels Vrang, Henrik B. Hansen, Palle Bekker Jeppesen, Laurie L. Baggio, Jacqueline A. Koehler, Daniel J. Drucker, Darleen A. Sandoval, Jacob Jelsing

Publikováno v: Molecular Metabolism, Vol 6, Iss 7, Pp 681-692 (2017)

Objective: The prevalence of obesity and related co-morbidities is reaching pandemic proportions. Today, the most effective obesity treatments are glucagon-like peptide 1 (GLP-1) analogs and bariatric surgery. Interestingly, both intervention paradig

Externí odkaz: https://doaj.org/article/cfc80da140484ad69afe224da8fbaaee

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Autor: Knud J. Jensen, Søren Blok van Witteloostuijn, Søren L. Pedersen, Mikkel B. Thygesen, Manuel C. Martos-Maldonado, Jacob Jelsing, Niels Vrang, Kasper K. Sørensen, Pernille Wismann, Esben M. Bech

Publikováno v: Journal of Medicinal Chemistry. 60:7434-7446

Noncovalent binding of biopharmaceuticals to human serum albumin protects against enzymatic degradation and renal clearance. Herein, we investigated the effect of mono- or divalent small-molecule albumin binders for half-life extension of peptides. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a0fb5a9e969193c0073c64a97f294d
https://doi.org/10.1021/acs.jmedchem.7b00787

Westernized Diet–Induced Insulin Resistance in Mice Is Associated with Focal Duodenal Hyperplasia

Autor: Soumitra S. Ghosh, Pernille Wismann, Francesco Rubino, Harith Rajagopalan, Kristoffer T.G. Rigbolt, David G. Maggs

Publikováno v: Diabetes. 67

Westernized diet (WD; high fat and sugar) induces an insulin resistant state associated with obesity and type 2 diabetes (T2D). Duodenal exclusion surgery in obese T2D patients implicates the duodenum as a key GI region involved in insulin resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb2442e3881a1bd2c0c60a099cd4b7e5
https://doi.org/10.2337/db18-1900-p

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

Autor: Henrik B. Hansen, Darleen A. Sandoval, Palle Jeppesen, Thomas Secher, Niels Vrang, Daniel J. Drucker, Jacob Jelsing, Pernille Barkholt, Pernille Wismann, Laurie L. Baggio, Jacqueline A. Koehler

Publikováno v: Molecular Metabolism
Wismann, P, Barkholt, P, Secher, T, Vrang, N, Hansen, H B, Jeppesen, P B, Baggio, L L, Koehler, J A, Drucker, D J, Sandoval, D A & Jelsing, J 2017, ' The endogenous preproglucagon system is not essential for gut growth homeostasis in mice ', Molecular Metabolism, vol. 6, no. 7, pp. 681-692 . https://doi.org/10.1016/j.molmet.2017.04.007
Molecular Metabolism, Vol 6, Iss 7, Pp 681-692 (2017)

Objective The prevalence of obesity and related co-morbidities is reaching pandemic proportions. Today, the most effective obesity treatments are glucagon-like peptide 1 (GLP-1) analogs and bariatric surgery. Interestingly, both intervention paradigm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec378023ad8e064423f053730f6f4f2
https://pubmed.ncbi.nlm.nih.gov/28702324

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice.

Autor: Madsen, Mette Simone Aae^1,2, Holm, Jacob Bak³, Pallejà, Albert³, Wismann, Pernille¹, Fabricius, Katrine¹, Rigbolt, Kristoffer¹, Mikkelsen, Martin¹, Sommer, Morten², Jelsing, Jacob¹, Nielsen, Henrik Bjørn³, Vrang, Niels¹, Hansen, Henrik H.¹ hbh@gubra.dk

Publikováno v: Scientific Reports. 10/30/2019, Vol. 9 Issue 1, pN.PAG-N.PAG. 1p.