Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pernille Vahl"'
Autor:
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-27 (2023)
Abstract Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal
Externí odkaz:
https://doaj.org/article/43eb9c61abb047289a64eb505c8ecf73
Autor:
Ninna C. S. Voss, Thomas Dreyer, Mikkel B. Henningsen, Pernille Vahl, Bent Honoré, Ebbe Boedtkjer
Publikováno v:
Cancers, Vol 12, Iss 4, p 891 (2020)
The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinkin
Externí odkaz:
https://doaj.org/article/b609ea6c849a44b9b027b0284705d247
Autor:
Heleen K Bronsveld, Vibeke Jensen, Pernille Vahl, Marie L De Bruin, Sten Cornelissen, Joyce Sanders, Anssi Auvinen, Jari Haukka, Morten Andersen, Peter Vestergaard, Marjanka K Schmidt
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170084 (2017)
Women with diabetes have a worse survival after breast cancer diagnosis compared to women without diabetes. This may be due to a different etiological profile, leading to the development of more aggressive breast cancer subtypes. Our aim was to inves
Externí odkaz:
https://doaj.org/article/a05a6667875341eca43b7d2fa25e2f96
Autor:
Rasmus A. Sloth, Trine V. Axelsen, Maria Sofia Espejo, Nicolai J. Toft, Ninna C. S. Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer
Publikováno v:
Sloth, R A, Axelsen, T V, Espejo, M S, Toft, N J, Voss, N C S, Burton, M, Thomassen, M, Vahl, P & Boedtkjer, E 2022, ' Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival ', British Journal of Cancer, vol. 127, no. 7, pp. 1226-1238 . https://doi.org/10.1038/s41416-022-01911-6
Background: While cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and underlying molecular mechanisms responding to the tumour microenvironment remain unclear. Methods
Autor:
Mikkel B. Henningsen, Kezia McWhan, Vibeke S. Dam, Marco Mele, Katrine R. Hauerslev, Ninna C. S. Voss, Parag D. Dabir, Eva Balling, Helene L. Pedersen, Pernille Vahl, Tonje Johansen, Trine Tramm, Peer M. Christiansen, Ebbe Boedtkjer
Publikováno v:
Henningsen, M B, McWhan, K, Dam, V S, Mele, M, Hauerslev, K R, Voss, N C S, Dabir, P D, Balling, E, Pedersen, H L, Vahl, P, Johansen, T, Tramm, T, Christiansen, P M & Boedtkjer, E 2022, ' Amplified Ca 2+ dynamics and accelerated cell proliferation in breast cancer tissue during purinergic stimulation ', International Journal of Cancer, vol. 151, no. 7, pp. 1150-1165 . https://doi.org/10.1002/ijc.34147
Intracellular Ca 2+ dynamics shape malignant behaviors of cancer cells. Whereas previous studies focused on cultured cancer cells, we here used breast organoids and colonic crypts freshly isolated from human and murine surgical biopsies. We performed
Publikováno v:
Tramm, T, Vinter, H, Vahl, P, Özcan, D, Alsner, J & Overgaard, J 2022, ' Tumor-infiltrating lymphocytes predict improved overall survival after post-mastectomy radiotherapy: a study of the randomized DBCG82bc cohort ', Acta Oncologica, vol. 61, no. 2, pp. 153-162 . https://doi.org/10.1080/0284186X.2021.1989629
BACKGROUND: The predictive value of tumor-infiltrating lymphocytes (TILs) on the benefit from radiotherapy (RT) remains unclear. Our aim was to investigate the association between TILs and post-mastectomy RT (PMRT) regarding the risk of recurrence an
Autor:
Mikkel B, Henningsen, Kezia, McWhan, Vibeke S, Dam, Marco, Mele, Katrine R, Hauerslev, Ninna C S, Voss, Parag D, Dabir, Eva, Balling, Helene L, Pedersen, Pernille, Vahl, Tonje, Johansen, Trine, Tramm, Peer M, Christiansen, Ebbe, Boedtkjer
Publikováno v:
International journal of cancer. 151(7)
Intracellular Ca
Autor:
Mikkel H. Vendelbo, Steen Jakobsen, Niels Jessen, Ole Lajord Munk, Jørgen Frøkiær, Lars C. Gormsen, Elias Immanuel Ordell Sundelin, Nidal Al-Suliman, Steen B. Pedersen, Pernille Vahl
Publikováno v:
Sundelin, E I O, al-Suliman, N, Vahl, P, Vendelbo, M, Munk, O L, Jakobsen, S, Pedersen, S B, Frøkiær, J, Gormsen, L C & Jessen, N 2020, ' Metformin is distributed to tumor tissue in breast cancer patients in vivo : A 11 C-metformin PET/CT study ', Breast Cancer Research and Treatment, vol. 181, no. 1, pp. 107-113 . https://doi.org/10.1007/s10549-020-05621-6
Purpose: Epidemiological studies and randomized clinical trials suggest that the antidiabetic drug, metformin, may have anti-neoplastic effects. The mechanism that mediates these beneficial effects has been suggested to involve direct action on cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c10de03f0341c824645402f4e667420
https://pure.au.dk/portal/da/publications/metformin-is-distributed-to-tumor-tissue-in-breast-cancer-patients-in-vivo(a2f1283d-1e31-4dbb-a5ad-7f6959cb484a).html
https://pure.au.dk/portal/da/publications/metformin-is-distributed-to-tumor-tissue-in-breast-cancer-patients-in-vivo(a2f1283d-1e31-4dbb-a5ad-7f6959cb484a).html
Autor:
Ebbe Boedtkjer, Ninna C. S. Voss, Bent Honoré, Pernille Vahl, Thomas Dreyer, Mikkel B. Henningsen
Publikováno v:
Cancers, Vol 12, Iss 891, p 891 (2020)
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinkin
Autor:
Nicolai Jessen, Ebbe Boedtkjer, Stine F. Pedersen, Trine V Axelsen, Soojung Lee, Pernille Vahl
Publikováno v:
Lee, S, Axelsen, T V, Jessen, N, Pedersen, S F, Vahl, P & Boedtkjer, E 2018, ' Na +,HCO 3 –-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice ', Oncogene, vol. 37, no. 41, pp. 5569-5584 . https://doi.org/10.1038/s41388-018-0353-6
Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7654b11d4dea51650c8a3abd257d60ad
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html