Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pernille Jansen"'
Autor:
Peder Madsen, Pernille Jansen, Jens R. Nyengaard, Erik Ilsø Christensen, Anders Nykjaer, Kenneth K. Teng, Camilla Gustafsen, Claus Munck Petersen, Therese Ovesen, Jacob Tauris, Elisabeth Schwarz
Publikováno v:
European Journal of Neuroscience. 33:622-631
The precursor of the neurotrophin NGF (proNGF) serves physiological functions distinct from its mature counterpart as it induces neuronal apoptosis through activation of a p75 neurotrophin receptor (p75 NTR ) and Sortilin death-signalling complex. Th
Autor:
Gary R. Lewin, Simon Glerup, Anja W. Fjorback, Bettina Erdmann, Mads Kjolby, Moses V. Chao, Thomas E. Willnow, Mette Richner, Jens R. Nyengaard, Sune Skeldal, Lino Tessarollo, Anders Nykjaer, Pernille Jansen, Christian Bjerggaard Vaegter
Publikováno v:
Vaegter, C B, Jansen, P, Fjorback, A W, Glerup, S, Skeldal, S, Kjølby, M F, Richner, M, Erdmann, B, Nyengaard, J R, Tessarollo, L, Lewin, G R, Willnow, T E, Chao, M V & Nykjaer, A 2011, ' Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling ', Nature Neuroscience, vol. 14, no. 1, pp. 54-61 . https://doi.org/10.1038/nn.2689
Binding of target-derived neurotrophins to Trk receptors at nerve terminals is required to stimulate neuronal survival, differentiation, innervation and synaptic plasticity. The distance between the soma and nerve terminal is great, making efficient
Autor:
Fuyu Lin, Thomas E. Willnow, Oleg Lioubinski, Gary R. Lewin, Pernille Jansen, Andreas Eilers, Susanne S. Sjoegaard, Barbara L. Hempstead, Klaus M. Giehl, Jens R. Nyengaard, Anders Nykjaer, Kenneth K. Teng, Claus Munck Petersen, Michael Gotthardt, Tilman Breiderhoff
Publikováno v:
Jansen, P, Giehl, K, Nyengaard, J R, Teng, K, Lioubinski, O, Sjoegaard, S S, Breiderhoff, T, Gotthardt, M, Lin, F, Eilers, A, Petersen, C M, Lewin, G R, Hempstead, B L, Willnow, T E & Nykjaer, A 2007, ' Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. ', Nature Neuroscience, vol. 10, no. 11, pp. 1449-57 . https://doi.org/10.1038/nn2000
Neurotrophins are essential for development and maintenance of the vertebrate nervous system. Paradoxically, although mature neurotrophins promote neuronal survival by binding to tropomyosin receptor kinases and p75 neurotrophin receptor (p75(NTR)),
Autor:
Anders Nykjaer, Colin L. Masters, Joachim Behlke, Vanessa Schmidt, Kelly R. Bales, Steven M. Paul, Roberto Cappai, Michael Gotthardt, Bradley T. Hyman, Christine A. F. von Arnim, Xin Wu, Pernille Jansen, Olav M. Andersen, Elliott J. Mufson, Jørgen Gliemann, Robert Spoelgen, Tilman Breiderhoff, Thomas E. Willnow, Juliane Reiche
Publikováno v:
Proceedings of the National Academy of Sciences. 102:13461-13466
sorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons. Its homology to sorting receptors that shuttle between the plasma membrane, endosomes, and the Golgi suggests a related function i
Autor:
Jakob Torp Madsen, Jan Bert Gramsbergen, Morten Meyer, Christian Hesslinger, Jens Zimmer, Pernille Jansen
Publikováno v:
Journal of Neurochemistry. 85:214-223
Complex-I inhibition and oxidative processes have been implicated in the loss of nigral dopamine neurones in Parkinson’s disease and the toxicity of MPTP and its metabolite MPP + . Tetrahydrobiopterin, an essential cofactor for tyrosine hydroxylase
Autor:
Uwe Schlichting, Anders Nykjaer, Maren Wellner, Eckehard Wolf, Jörg Robert Leheste, Ingrid Renner-Müller, Flemming Melsen, Pernille Jansen, Thomas E. Willnow, Sebastian Bachmann, Troels T. Andreassen
Publikováno v:
The FASEB Journal. 17:247-249
Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney. Recently, we demonstrated that this receptor is essential for the renal uptake and conversion of 25-OH vitamin D3 to 1,25-(OH)2 vitamin D3, a central step in vit
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
Autor:
Olav M. Andersen, Joerg Heeren, Anders Nykjaer, Karen M. Pedersen, Anja W. Fjorback, Thomas E. Willnow, Peder Madsen, Pernille Jansen, Tilman Breiderhoff, Mads Kjolby
Publikováno v:
Cell metabolism. 12(3)
SummaryRecent genome-wide association studies (GWAS) have revealed strong association of hypercholesterolemia and myocardial infarction with SNPs on human chromosome 1p13.3. This locus covers three genes: SORT1, CELSR2, and PSRC1. We demonstrate that
Autor:
Morten Nielsen, Elisabeth Schwarz, Marco Kliemannel, Christian Jacobsen, Anders Nykjaer, Thomas E. Willnow, Claus Munck Petersen, Kenneth K. Teng, Barbara L. Hempstead, Pernille Jansen, Ramee Lee, Peder Madsen
Publikováno v:
Nature. 427(6977)
Sortilin (approximately 95 kDa) is a member of the recently discovered family of Vps10p-domain receptors, and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It acts as a receptor for neurotensin, but predominates in regi
Autor:
Jakob Torp, Madsen, Pernille, Jansen, Christian, Hesslinger, Morten, Meyer, Jens, Zimmer, Jan Bert, Gramsbergen
Publikováno v:
Journal of neurochemistry. 85(1)
Complex-I inhibition and oxidative processes have been implicated in the loss of nigral dopamine neurones in Parkinson's disease and the toxicity of MPTP and its metabolite MPP+. Tetrahydrobiopterin, an essential cofactor for tyrosine hydroxylase, ma
Autor:
Christian B Vaegter, Pernille Jansen, Anja W Fjorback, Simon Glerup, Sune Skeldal, Mads Kjolby, Mette Richner, Bettina Erdmann, Jens R Nyengaard, Lino Tessarollo, Gary R Lewin, Thomas E Willnow, Moses V Chao, Anders Nykjaer
Publikováno v:
Nature Neuroscience. 14:1217-1217