Physico-chemical characterization of aspirated and simulated human gastric fluids to study their influence on the intrinsic dissolution rate of cinnarizine

Autor: Pernille Barbre Pedersen, Ragna Berthelsen, Thomas Rades, Søren Astrup Jørgensen, Peter Vilmann, Daniel Bar-Shalom, Stefania Baldursdottir, Anette Müllertz

Publikováno v: Pedersen, P B, Berthelsen, R, Rades, T, Jørgensen, S A, Vilmann, P, Bar-Shalom, D, Baldursdottir, S & Müllertz, A 2022, ' Physico-chemical characterization of aspirated and simulated human gastric fluids to study their influence on the intrinsic dissolution rate of cinnarizine ', International Journal of Pharmaceutics, vol. 622, 121856 . https://doi.org/10.1016/j.ijpharm.2022.121856

To elucidate the critical parameters affecting drug dissolution in the human stomach, the intrinsic dissolution rate (IDR) of cinnarizine was determined in aspirated and simulated human gastric fluids (HGF). Fasted aspirated HGF (aspHGF) was collecte

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