Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Pernille B. Lærkegaard Hansen"'
Publikováno v:
Lyngsø, K S, Jensen, B L, Hansen, P B L & Dimke, H 2022, ' Endothelial Mineralocorticoid Receptor Ablation Confers Protection Towards Endothelial Dysfunction in Experimental Diabetes in Mice ', Acta Physiologica, vol. 234, no. 2, e13731 . https://doi.org/10.1111/apha.13731
Aim: With diabetes comes a significant risk of macrovascular and microvascular complications. Circulating aldosterone levels increase in patients with diabetes. Aldosterone can directly affect vascular function via activation of the mineralocorticoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c951ea75ea173254b78d5ce6c6df59
https://pubmed.ncbi.nlm.nih.gov/34519423
https://pubmed.ncbi.nlm.nih.gov/34519423
Autor:
Ida K. Lund, Shanya Supramaniyam, Boye L. Jensen, Camilla Enggaard, Maria H. Hansen, Henrik J. Andersen, Mette Staehr, Per Svenningsen, Ulla G. Friis, Pernille B. Lærkegaard Hansen, Kristian B Buhl
Publikováno v:
Andersen, H, Hansen, M H, Buhl, K B, Staehr, M, Friis, U G, Enggaard, C, Supramaniyam, S, Lund, I K, Svenningsen, P, Hansen, P B L & Jensen, B L 2020, ' Plasminogen Deficiency and Amiloride Mitigate Angiotensin II-Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel ', Journal of the American Heart Association, vol. 9, no. 23, 016387, pp. 1-36 . https://doi.org/10.1161/JAHA.120.016387
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Andersen, H, Hansen, M H, Buhl, K B, Stæhr, M, Friis, U G, Enggaard, C, Supramaniyam, S, Lund, I K, Svenningsen, P, Hansen, P B L & Jensen, B L 2020, ' Plasminogen Deficiency and Amiloride Mitigate Angiotensin II-Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel ', Journal of the American Heart Association, vol. 9, no. 23, e016387 . https://doi.org/10.1161/JAHA.120.016387
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Andersen, H, Hansen, M H, Buhl, K B, Stæhr, M, Friis, U G, Enggaard, C, Supramaniyam, S, Lund, I K, Svenningsen, P, Hansen, P B L & Jensen, B L 2020, ' Plasminogen Deficiency and Amiloride Mitigate Angiotensin II-Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel ', Journal of the American Heart Association, vol. 9, no. 23, e016387 . https://doi.org/10.1161/JAHA.120.016387
BackgroundDiabetic nephropathy is a common diabetes mellitus complication associated with hypertension, proteinuria, and excretion of urinary plasmin that activates the epithelial sodium channel, ENaC, in vitro. Here we hypothesized that the deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec5e6af86e7d6210a98217a6c0a40d4
https://curis.ku.dk/portal/da/publications/plasminogen-deficiency-and-amiloride-mitigate-angiotensin-iiinduced-hypertension-in-type-1-diabetic-mice-suggesting-effects-through-the-epithelial-sodium-channel(19a2798d-5153-41b9-bfa6-5dc8a2fdb58d).html
https://curis.ku.dk/portal/da/publications/plasminogen-deficiency-and-amiloride-mitigate-angiotensin-iiinduced-hypertension-in-type-1-diabetic-mice-suggesting-effects-through-the-epithelial-sodium-channel(19a2798d-5153-41b9-bfa6-5dc8a2fdb58d).html
Autor:
Kristina S. Lyngsø, Charlotte Brasch-Andersen, Kenneth Andersen, Anne D Thuesen, Pernille B. Lærkegaard Hansen, Paul M. Vanhoutte, Mark Burton
Publikováno v:
Thuesen, A D, Andersen, K, Lyngsø, K S, Burton, M, Brasch-Andersen, C, Vanhoutte, P M & Hansen, P B L 2018, ' Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice ', Pflügers Archiv-European Journal of Physiology, vol. 470, no. 2, pp. 355–365 . https://doi.org/10.1007/s00424-017-2068-x
Impairment of endothelial function with aging is accompanied by reduced nitric oxide (NO) production. T-type Cav3.1 channels augment nitric oxide and co-localize with eNOS. Therefore, the hypothesis was that T-type channels contribute to the endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b57d99a931ecc462a63bab01ffa98b
https://doi.org/10.1007/s00424-017-2068-x
https://doi.org/10.1007/s00424-017-2068-x
Autor:
Birgül Kurt, Mette Staehr, Pernille B. Lærkegaard Hansen, Gitte R. Hinrichs, Claus Bistrup, Boye L. Jensen, Christina Stolzenburg Oxlund, Per Svenningsen, Mie R. Hansen, Ilona Schwarzensteiner, Ib Abildgaard Jacobsen, Anja Toft, Anne D Thuesen
Publikováno v:
Stolzenburg Oxlund, C, Kurt, B, Schwarzensteiner, I, Hansen, M R, Stæhr, M, Svenningsen, P, Jacobsen, I A, Hansen, P B, Thuesen, A D, Toft, A, Hinrichs, G R, Bistrup, C & Jensen, B L 2017, ' Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin ', Pfluegers Archiv, vol. 469, no. 5-6, pp. 655–667 . https://doi.org/10.1007/s00424-017-1938-6
The proteinase prostasin is a candidate mediator for aldosterone-driven proteolytic activation of the epithelial sodium channel (ENaC). It was hypothesized that the aldosterone-mineralocorticoid receptor (MR) pathway stimulates prostasin abundance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6235fd863d3e55514ccd4f982e378325
https://doi.org/10.1007/s00424-017-1938-6
https://doi.org/10.1007/s00424-017-1938-6
Autor:
Ditte Caroline Andersen, Louise Ladebo Rasmussen, Anne D Thuesen, Pernille B. Lærkegaard Hansen, Stine Louise Høyer Finsen, Boye L. Jensen
Publikováno v:
Thuesen, A D, Finsen, S L H, Ladebo Rasmussen, L, Andersen, D C, Jensen, B L & Hansen, P B L 2019, ' Deficiency of T-type Ca 2+ channels Ca v 3.1 and Ca v 3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice ', American Journal of Physiology: Renal Physiology, vol. 317, no. 2, pp. F254-F263 . https://doi.org/10.1152/ajprenal.00121.2018
T-type Ca2+ channel Cav3.1 promotes microvessel contraction ex vivo. It was hypothesized that in vivo, functional deletion of Cav3.1, but not Cav3.2, protects mice against angiotensin II (ANG II)-induced hypertension. Mean arterial blood pressure (MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021d60e4811ec478e4fd66d934cf97a5
https://findresearcher.sdu.dk:8443/ws/files/153084178/Deficiency_of_T_type_Ca_2_channels_Ca_v3.1_and_Ca_v3.2_has_no_effect_on_angiotensin_II_induced_hypertension_but_differential_effect_on_plasma_aldosterone_in_mice.pdf
https://findresearcher.sdu.dk:8443/ws/files/153084178/Deficiency_of_T_type_Ca_2_channels_Ca_v3.1_and_Ca_v3.2_has_no_effect_on_angiotensin_II_induced_hypertension_but_differential_effect_on_plasma_aldosterone_in_mice.pdf
Autor:
Kate Lykke Lambertsen, Kristoffer Rosenstand, Ditte Gry Ellman, Peter Gennemark, Per Svenningsen, Anna Reznichenko, Kenneth Andersen, Pernille B. Lærkegaard Hansen, Paul M. Vanhoutte, Rasmus Terp
Publikováno v:
Rosenstand, K, Andersen, K, Terp, R, Gennemark, P, Ellman, D G, Reznichenko, A, Lambertsen, K L, Vanhoutte, P M, Hansen, P B L & Svenningsen, P 2020, ' Deficiency of T-type voltage-gated calcium channels results in attenuated weight gain and improved endothelium-dependent dilatation of resistance vessels induced by a high-fat diet in mice ', Journal of Physiology and Biochemistry, vol. 76, no. 1, pp. 135-145 . https://doi.org/10.1007/s13105-020-00728-2
The deletion of T-type Ca v3.1 channels may reduce high-fat diet (HFD)-induced weight gain, which correlates positively with obesity and endothelial dysfunction. Therefore, experiments were designed to study the involvement of T-type Ca v3.1 channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e5bb8eda13a69a2ce45704d6bb2c18
https://pubmed.ncbi.nlm.nih.gov/32016773
https://pubmed.ncbi.nlm.nih.gov/32016773
Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor
Autor:
Ditte Gry Ellman, Seth G. N. Grant, Ellie J. Tuck, Kristian Strømgaard, Bettina Hjelm Clausen, Lotte K. Kristensen, Marc Heitz, Dennis Özcelik, Maksym V. Kopanitsa, Anders Bach, Flemming Fryd Johansen, Pernille B. Lærkegaard Hansen, Henrik Hasseldam, Karin Lykke-Hartmann, Maria Gammelstrup Andersen, Kate Lykke Lambertsen
Publikováno v:
Bach, A, Clausen, B H, Kristensen, L K, Andersen, M G, Ellman, D G, Hansen, P B L, Hasseldam, H, Heitz, M, Özcelik, D, Tuck, E J, Kopanitsa, M V, Grant, S G N, Lykke-Hartmann, K, Johansen, F F, Lambertsen, K L & Strømgaard, K 2019, ' Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor ', Neuropharmacology, vol. 150, pp. 100-111 . https://doi.org/10.1016/j.neuropharm.2019.02.035
Bach, A, Clausen, B H, Kristensen, L K, Andersen, M G, Ellman, D G, Hansen, P B L, Hasseldam, H, Heitz, M, Özcelik, D, Tuck, E J, Kopanitsa, M V, Grant, S G N, Lykke-hartmann, K, Johansen, F F, Lambertsen, K L & Strømgaard, K 2019, ' Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor ', Neuropharmacology, vol. 150 . https://doi.org/10.1016/j.neuropharm.2019.02.035
Bach, A, Clausen, B H, Kristensen, L K, Andersen, M G, Ellman, D G, Hansen, P B L, Hasseldam, H, Heitz, M, Özcelik, D, Tuck, E J, Kopanitsa, M V, Grant, S G N, Lykke-hartmann, K, Johansen, F F, Lambertsen, K L & Strømgaard, K 2019, ' Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor ', Neuropharmacology, vol. 150 . https://doi.org/10.1016/j.neuropharm.2019.02.035
Inhibition of postsynaptic density protein-95 (PSD-95) decouples N-methyl-d-aspartate (NMDA) receptor downstream signaling and results in neuroprotection after focal cerebral ischemia. We have previously developed UCCB01-144, a potent dimeric PSD-95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaba9b8ffdf9dfc9af46f51cc576309
http://hdl.handle.net/10044/1/68105
http://hdl.handle.net/10044/1/68105
Autor:
Pernille B. Lærkegaard Hansen, Anja Toft, Boye L. Jensen, Mia Jensen, Kasper Bostlund Assersen, Reza Zamani, Lars Lund, Andreas Frees, Kirsten Madsen, Frank Schweda
Publikováno v:
Jensen, M, Frees, A, Assersen, K B, Madsen, K, Lund, L, Zamani, R, Toft, A, Hansen, P B L, Schweda, F & Jensen, B L 2021, ' LOCALIZATION OF NATRIURETIC PEPTIDE RECEPTORS IN HUMAN KIDNEY TISSUE ', Journal of Hypertension, vol. 39, no. Suppl. 1, pp. E300 . https://doi.org/10.1097/01.hjh.0000747924.16362.86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e24aab59538fc0c3e182ba016050a00
https://doi.org/10.1097/01.hjh.0000747924.16362.86
https://doi.org/10.1097/01.hjh.0000747924.16362.86
Autor:
Thomas Hartig Braunstein, Lars Juhl Jensen, Max Salomonsson, Rasmus Hassing Frandsen, Pernille B. Lærkegaard Hansen, Charlotte Mehlin Sorensen, Niels-Henrik Holstein-Rathlou
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:541-550
Renal autoregulation protects glomerular capillaries against increases in renal perfusion pressure (RPP). In the mesentery, both L- and T-type calcium channels are involved in autoregulation. L-type calcium channels participate in renal autoregulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8cd7dd9744c97b6b72e067cc75fc0f2
https://doi.org/10.1007/s00424-015-1770-9
https://doi.org/10.1007/s00424-015-1770-9
Autor:
Ying Ge, Shaohui Wang, Eddie Y. Liu, Yan Lu, Liang Cheng, Paul L. Huang, Lei Wang, Yiling Fu, Ruisheng Liu, Jie Zhang, Fan Fan, Jin Wei, Pernille B. Lærkegaard Hansen, Jennifer S. Pollock, David E. Stec, Richard J. Roman, Luis A. Juncos
Publikováno v:
Lu, Y, Wei, J, Stec, D E, Roman, R J, Ge, Y, Cheng, L, Liu, E Y, Zhang, J, Hansen, P B L, Fan, F, Juncos, L A, Wang, L, Pollock, J, Huang, P L, Fu, Y, Wang, S & Liu, R 2016, ' Macula Densa Nitric Oxide Synthase 1β Protects against Salt-Sensitive Hypertension ', Journal of the American Society of Nephrology, vol. 27, no. 8, pp. 2346-2356 . https://doi.org/10.1681/asn.2015050515
Nitric oxide (NO) is an important negative modulator of tubuloglomerular feedback responsiveness. We recently found that macula densa expresses a-, b-, and g-splice variants of neuronal nitric oxide synthase 1 (NOS1), and NOS1b expression in the macu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e807ae0cd977f9533bd4ca669d7f21
https://doi.org/10.1681/asn.2015050515
https://doi.org/10.1681/asn.2015050515