Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Pernilla Wittung-Stafshede"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12849 (2023)
The assembly of α-synuclein into cross-β structured amyloid fibers results in Lewy body deposits and neuronal degeneration in Parkinson’s disease patients. As the cell environment is highly crowded, interactions between the formed amyloid fibers
Externí odkaz:
https://doaj.org/article/cfab2cc36bd14ce498b3279925d47032
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The concept of Molecular Crowding depicts the high density of diverse molecules present in the cellular interior. Here, we determine the impact of low molecular weight and larger molecules on binding capacity of single-stranded DNA (ssDNA) t
Externí odkaz:
https://doaj.org/article/8a50fd7795844c2d80b2f7d036f8616f
Publikováno v:
QRB Discovery, Vol 2 (2021)
Sweden tops gender equality rankings, but Swedish academia is still lacking women in top positions. To address gender inequality in its faculty, Chalmers University of Technology has invested 300 million SEK (30 million Euros) over 10 years in Gender
Externí odkaz:
https://doaj.org/article/25ad2603727246faa9f4a80a5fcffd2f
Publikováno v:
QRB Discovery, Vol 2 (2021)
Although the consequences of the crowded cell environments may affect protein folding, function and misfolding reactions, these processes are often studied in dilute solutions in vitro. We here used biophysical experiments to investigate the amyloid
Externí odkaz:
https://doaj.org/article/b40209cc7320407b83ec5b6d9ddc1f2f
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1887 (2021)
Copper plays a key role in cancer metastasis, which is the most common cause of cancer death. Copper depletion treatment with tetrathiomolybdate (TM) improved disease-free survival in breast cancer patients with high risk of recurrence in a phase II
Externí odkaz:
https://doaj.org/article/baaa161386994dfebd2d227710fbe01d
Autor:
Timothy R Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian
Publikováno v:
eLife, Vol 9 (2020)
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. While genetic and environmental factors can influence amyloid forma
Externí odkaz:
https://doaj.org/article/a828d9d829724627bc449f3bc4f8d4bc
Autor:
Maria Matson Dzebo, Stéphanie Blockhuys, Sebastian Valenzuela, Emanuele Celauro, Elin K. Esbjörner, Pernilla Wittung-Stafshede
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 443-449 (2018)
The anaphase-promoting complex (APC) is involved in several processes in the cell cycle, most prominently it facilitates the separation of the sister chromatids during mitosis, before cell division. Because of the key role in the cell cycle, APC is s
Externí odkaz:
https://doaj.org/article/43d997190c004c918d05c9376462c9e1
Autor:
Emma Lorentzon, Istvan Horvath, Ranjeet Kumar, Joana Isabel Rodrigues, Markus J. Tamás, Pernilla Wittung-Stafshede
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11455 (2021)
Exposure to heavy metals, including arsenic and cadmium, is associated with neurodegenerative disorders such as Parkinson’s disease. However, the mechanistic details of how these metals contribute to pathogenesis are not well understood. To search
Externí odkaz:
https://doaj.org/article/93304e0595a04fb29a3e1ab124338036
Autor:
Nina Horn, Pernilla Wittung-Stafshede
Publikováno v:
Biomedicines, Vol 9, Iss 4, p 391 (2021)
Copper is vital for numerous cellular functions affecting all tissues and organ systems in the body. The copper pump, ATP7A is critical for whole-body, cellular, and subcellular copper homeostasis, and dysfunction due to genetic defects results in Me
Externí odkaz:
https://doaj.org/article/ea17427939d04e03a6eb405cb45f37a4
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 924 (2020)
Plaque deposits composed of amyloid-β (Aβ) fibrils are pathological hallmarks of Alzheimer’s disease (AD). Although copper ion dyshomeostasis is apparent in AD brains and copper ions are found co-deposited with Aβ peptides in patients’ plaques
Externí odkaz:
https://doaj.org/article/335b8cd9a24e4aa592546e1f04ebddb2