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PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor

Autor: Ambler, Rachel, Edmunds, Grace, Tan, Sin Lih, Cirillo, Silvia, Pernes, Jane I., Ruan, Xiongtao, Huete-Carrasco, Jorge, Wong, Carissa C W, Lu, Jiahe, Ward, Juma R R, Toti, Giulia, Hedges, Alan J, Dovedi, Simon, Murphy, Robert F., Morgan, David, Wuelfing, Christoph

Publikováno v: Ambler, R, Edmunds, G, Tan, S L, Cirillo, S, Pernes, J I, Ruan, X, Huete-Carrasco, J, Wong, C C W, Lu, J, Ward, J R R, Toti, G, Hedges, A J, Dovedi, S, Murphy, R F, Morgan, D & Wuelfing, C 2020, ' PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor ', Science Signaling, vol. 13, no. 649, eaau4815 . https://doi.org/10.1101/443788, https://doi.org/10.1126/scisignal.aau4518

CD8+ T cell killing of tumor cells is suppressed by the tumor microenvironment. Inhibitory receptors, prominently PD-1, are key mediators of this suppression. To discover cellular defects triggered by tumor exposure and associated PD-1 signaling, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbbb5b80ae7644b8465cffb946a15ef
https://hdl.handle.net/1983/88e99fd9-00a0-40a1-ba18-83917301221a

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor.

Autor: Ambler R; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Edmunds GL; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Tan SL; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Cirillo S; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Pernes JI; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Ruan X; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Huete-Carrasco J; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Wong CCW; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Lu J; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Ward J; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Toti G; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Hedges AJ; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK., Dovedi SJ; R&D Oncology, AstraZeneca, Granta Park, Cambridge CB21 6GH, UK., Murphy RF; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Departments of Biological Sciences, Biomedical Engineering and Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Freiburg Institute for Advanced Studies and Faculty of Biology, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany., Morgan DJ; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK. d.j.morgan@bristol.ac.uk christoph.wuelfing@bristol.ac.uk., Wülfing C; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK. d.j.morgan@bristol.ac.uk christoph.wuelfing@bristol.ac.uk.

Publikováno v: Science signaling [Sci Signal] 2020 Sep 15; Vol. 13 (649). Date of Electronic Publication: 2020 Sep 15.