Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Permphan, Dharmasaroja"'
Publikováno v:
Research in Pharmaceutical Sciences, Vol 19, Iss 1, Pp 105-120 (2024)
Background and purpose: Oxidative stress plays an important role in Alzheimer's disease (AD) pathogenesis. Moringa oleifera leaf (MOL) extract has been shown to have antioxidant activities. Here, we studied the antioxidative and anti-apoptotic effect
Externí odkaz:
https://doaj.org/article/fce13556e2f24d20b41e8a044f5fcc6d
Publikováno v:
The Scientific World Journal, Vol 2023 (2023)
The tissue-specific protein eEF1A2 has been linked to the development of neurological disorders. The role of eEF1A2 in the pathogenesis of Parkinson’s disease (PD) has yet to be investigated. The aim of this study was to determine the potential neu
Externí odkaz:
https://doaj.org/article/7211f6f3e72e45278e8d7ab73606dc03
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2023 (2023)
Metformin (MET) and rapamycin (RAPA) have been reported to protect against neurodegeneration in cellular and animal models of Parkinson’s disease (PD). MET, which is a first-line drug for type 2 diabetes, and RAPA are known as mTORC1 inhibitors. ME
Externí odkaz:
https://doaj.org/article/98c995f676cf4e50be5690a23bf008ce
Publikováno v:
International Journal of Hematology-Oncology and Stem Cell Research, Vol 15, Iss 4 (2021)
Background The protein kinase B/mammalian target of the rapamycin (Akt/mTOR) pathway is one of the most potent prosurvival signaling cascades that is constitutively active in neuroblastoma. The eukaryotic translation elongation factor-1, alpha-2 (eEF
Externí odkaz:
https://doaj.org/article/f62388a636eb4db9bb2af1d0c576f6a9
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the aggregation of α-synuclein protein and selective death of dopaminergic (DA) neurons in the substantia nigra of the midbrain. Although the molecular pathogenesis of PD is
Externí odkaz:
https://doaj.org/article/257c7418b0d24b9ba45bfa0b0a6f5b05
Autor:
Permphan Dharmasaroja
Publikováno v:
Ramathibodi Medical Journal. 45:43-51
Setting standards is an important aspect of a grading system, which should be fair, reasonable, practical, and transparent. Distinct types of assessments result in different score distributions and different pass grades, and substantial errors can oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1944b3a39af2e475b4c233b5b1fb02
https://doi.org/10.33165/rmj.2022.45.2.255947
https://doi.org/10.33165/rmj.2022.45.2.255947
Publikováno v:
NeuroReport. 33:336-344
The translation elongation factor-1, alpha-2 (eEF1A2) plays an important role in protein synthesis. Mutations in this gene have been described in individuals with neurodevelopmental disorders. Here, we silenced the expression of eEFA2 in human SH-SY5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd3efd69d9b9d05f21274bde45b046c
https://doi.org/10.1097/wnr.0000000000001791
https://doi.org/10.1097/wnr.0000000000001791
Autor:
Permphan Dharmasaroja
Publikováno v:
Cureus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a6a03532698bbc46909530069382493
https://doi.org/10.7759/cureus.35334
https://doi.org/10.7759/cureus.35334
Publikováno v:
Neuroscience Research. 164:55-69
1-Methyl-4-phenylpyridinium ion (MPP+) is widely used to induce a cellular model of Parkinson's disease (PD) in dopaminergic cell lines. Downregulation of the protein translation elongation factor 1 alpha (eEF1A) has been reported in the brain tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e224d6ecac1e4f903ae90c776a21a0
https://doi.org/10.1016/j.neures.2020.03.013
https://doi.org/10.1016/j.neures.2020.03.013
Publikováno v:
Parkinson's Disease, Vol 2016 (2016)
The PI3K/Akt/mTOR pathway is one of dysregulated pathways in Parkinson’s disease (PD). Previous studies in nonneuronal cells showed that Akt regulation can be increased by eukaryotic protein elongation factor 1 alpha 2 (eEF1A2). eEF1A2 is proposed
Externí odkaz:
https://doaj.org/article/65eda8bac6b343f68152e135a91f8f47