Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Perlyn Kwek"'
Autor:
Susmitha Vuddagiri, Doris Hui Ying Tee, Sandra Sim, Alvin W. Hung, Gang Wang, Thomas H. Keller, Li Hong Tan, Zhiyuan Ke, Anders Poulsen, Nithya Baburajendran, Boping Liu, Vishal Pendharkar, Pearly Shuyi Ng, Jeffrey Hill, Jothi Anantharajan, Joma Joy, May Ann Lee, Zekui Perlyn Kwek, Kanda Sangthongpitag, Sifang Wang, Vithya Manoharan, Klement Foo, Chuhui Huang, Nur Huda Binte Ahmad
Publikováno v:
Bioorganicmedicinal chemistry. 49
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor disease prognosis and acquired drug resistance. Utilizing a fragment-based l
Autor:
Jacek Kwiatkowski, Boping Liu, Shermaine Pang, Nur Huda Binte Ahmad, Gang Wang, Anders Poulsen, Haiyan Yang, Yong Rui Poh, Doris Hui Ying Tee, Esther Ong, Priya Retna, Nurul Dinie, Perlyn Kwek, John Liang Kuan Wee, Vithya Manoharan, Choon Bing Low, Peck Gee Seah, Vishal Pendharkar, Kanda Sangthongpitag, Joma Joy, Nithya Baburajendran, Anna Elisabet Jansson, Kassoum Nacro, Jeffrey Hill, Thomas H. Keller, Alvin W. Hung
Publikováno v:
Journal of medicinal chemistry. 63(2)
Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various cancers. Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation of eIF4E. Structure-activity relat
Autor:
Jeffrey Hill, Joma Joy, Grace Lin, Nurul Dinie, Justina Fulwood, Sin Yin Chew, Xiaoying Koh-Stenta, Sugunavathi Sepramaniam, Xin Hui Chew, Rong Li, Melgious Jin Yan Ang, May Ann Lee, Alex Matter, Weixuan Yu, Zhiyuan Ke, Anna Ngo, Hwa Hwa Chung, Susmitha Vuddagiri, Kanda Sangthongpitag, Klement Foo, Vithya Manoharan, C. S. Brian Chia, Sravanthy Manesh, Esther H. Q. Ong, Nithya Baburajendran, Chuhui Huang, Zekui Perlyn Kwek, John Liang Kuan Wee, Yun Shan Chew, Priya Retna, Thomas H. Keller, Anders Poulsen, Si Si Liew, Choon Bing Low, Vishal Pendharkar
Publikováno v:
ACS Med Chem Lett
[Image: see text] SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a957218bb54c41c184fbdaf7cb115a0
https://europepmc.org/articles/PMC6580565/
https://europepmc.org/articles/PMC6580565/
Autor:
Vithya Manoharan, Yun Xuan Wong, Esther H. Q. Ong, Kassoum Nacro, John Liang Kuan Wee, Zekui Perlyn Kwek, Sharon Xiaodai Lim, Jeffrey Hill, Yun Shan Chew, Zhi Ying Poh, S. Tiong Ong, Thomas H. Keller, Li Jun Ding, Joma Joy, Vishal Pendharkar, Samantha Guo, Kanda Sangthongpitag, Anders Poulsen, Hai Yan Yang, May Ann Lee, Boping Liu, Meng Ling Choong, Duraiswamy Athisayamani Jeyaraj, Joseph Cherian, Melvyn Ho
Publikováno v:
Journal of Medicinal Chemistry. 59:3063-3078
Clinically used BCR-ABL1 inhibitors for the treatment of chronic myeloid leukemia do not eliminate leukemic stem cells (LSC). It has been shown that MNK1 and 2 inhibitors prevent phosphorylation of eIF4E and eliminate the self-renewal capacity of LSC
Autor:
Sugunavathi Sepramaniam, Thomas H. Keller, Alex Matter, Xiaoying Koh-Stenta, May Ann Lee, Nurul Dinie, Anders Poulsen, Justina Fulwood, Weixuan Yu, Anna Ngo, Grace Lin, Sin Yin Chew, Xin Hui Chew, Joma Joy, Melgious Jin Yan Ang, Priya Retna, Kanda Sangthongpitag, Nithya Baburajendran, John Liang Kuan Wee, Klement Foo, Jeffrey Hill, Vithya Manoharan, Zekui Perlyn Kwek, Esther H. Q. Ong, Zhiyuan Ke, Rong Li, Chuhui Huang, Hwa Hwa Chung, C. S. Brian Chia, Yun Shan Chew, Susmitha Vuddagiri, Sravanthy Manesh, Vishal Pendharkar, Si Si Liew, Choon Bing Low
Publikováno v:
ACS Medicinal Chemistry Letters. 10:1240-1240
Autor:
Perlyn Kwek Zekui, Carol Koh-Stenta Xiaoying, Nithya Baburajendran, Sin Yin Chew, Joma Joy, Jeffrey Hill, Anders Poulsen, Klement Foo Jihao, Anna Elisabet Jansson, John Wee Liang Kuan
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:a470-a470
Publikováno v:
In FEBS Letters 2010 584(14):3149-3152
Autor:
Vishal Pendharkar, Sharon Xiaodai Lim, Kanda Sangthongpitag, Joseph Cherian, Samantha Guo, Hongqian Esther Ong, Joma Joy, Melvyn Ho, May Ann Lee, Tiong S. Ong, Meng Ling Choong, Jeffrey Hill, Kassoum Nacro, Anders Poulsen, Jun L. Ding, Zhi Ying Poh, Haiyan Yang, Boping Liu, Charles Chuah, Thomas H. Keller, Alex Matter, Zekui Perlyn Kwek
Publikováno v:
Cancer Research. 74:948-948
Although targeting the BCR-ABL kinase with tyrosine kinase inhibitors (TKI) is effective in chronic phase (CP) CML, targeting BCR-ABL alone is not sufficient to treat late-stage or blast crisis (BC) CML. In BC CML, granulocyte macrophage progenitors
Autor:
Wee Liang Kuan, Joy, Joma, Ng Fui Mee, Perlyn, Kwek Zekui, Then Siew Wen, Thuy Nguen, James, Joanne, Chai, Elaine, Flotow, Horst, Crasta, Sharon, Chua, Kelvin, Ng Sok Peng, Hill, Jeffrey
Publikováno v:
Biochemistry Insights; 2010, Issue 3, p41-46, 6p, 1 Color Photograph, 1 Diagram, 1 Chart
Akademický článek
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