Effects of repetitive Transcranial Magnetic Stimulation in aged rats depend on pre-treatment cognitive status: Toward individualized intervention for successful cognitive aging

Autor: Marina Weiler, Perla Moreno-Castilla, Hannah M. Starnes, Edward L.R. Melendez, Kevin C. Stieger, Jeffrey M. Long, Peter R. Rapp

Publikováno v: Brain Stimulation, Vol 14, Iss 5, Pp 1219-1225 (2021)

Background: Repetitive Transcranial Magnetic Stimulation (rTMS) has shown initial promise in combating age-related cognitive decline and dementia. The nature and severity of cognitive aging, however, varies markedly between individuals. Objective/hyp

Externí odkaz: https://doaj.org/article/7c4d68af51f84f148944671ac43390db

The role of the lateral orbitofrontal cortex in creating cognitive maps

Autor: Kauê Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P. H. Gardner, Peter Dayan, Geoffrey Schoenbaum

Publikováno v: Nat Neurosci
Nature Neuroscience

We use mental models of the world – cognitive maps - to guide behavior. The lateral orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps to simulate outcomes, but recent evidence suggests that it may instead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf00e6b369260fd5b077140a18fc0fbc
https://doi.org/10.1038/s41593-022-01216-0

Spatial contextual recognition memory updating is modulated by dopamine release in the dorsal hippocampus from the locus coeruleus

Autor: Donovan K. Gálvez-Márquez, Mildred Salgado-Ménez, Perla Moreno-Castilla, Luis Rodríguez-Durán, Martha L. Escobar, Fatuel Tecuapetla, Federico Bermudez-Rattoni

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(49)

Detecting novelty is critical to consolidate declarative memories, such as spatial contextual recognition memory. It has been shown that stored memories, when retrieved, are susceptible to modification, incorporating new information through an updati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9ff9708223eb66a276f6aa3fc3edb0
https://pubmed.ncbi.nlm.nih.gov/36442129

The role of the orbitofrontal cortex in creating cognitive maps

Autor: Kauê Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P. H. Gardner, Peter Dayan, Geoffrey Schoenbaum

We use internal models of the external world to guide behavior, but little is known about how these cognitive maps are created. The orbitofrontal cortex (OFC) is typically thought to access these maps to support model-based decision-making, but it ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fab05e8cf0ed6a97ebc0f7b41fcfa94
https://hdl.handle.net/21.11116/0000-0009-DBF0-1

Transcriptional, Behavioral and Biochemical Profiling in the 3xTg-AD Mouse Model Reveals a Specific Signature of Amyloid Deposition and Functional Decline in Alzheimer’s Disease

Autor: Navei Cerda-Hernández, Federico Bermúdez-Rattoni, Humberto Gutierrez, Araxi O. Urrutia, Rodrigo Pérez-Ortega, Perla Moreno-Castilla, Mayra L Ruiz-Tejada-Segura, Atahualpa Castillo-Morales, Wencheng Yin, Jimena Monzón-Sandoval

Publikováno v: Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2020)
Yin, W, Cerda Hernandez, N, Castillo Morales, A, Ruiz Tejada Segura, M, Monzón Sandoval, J, Moreno Castillo, P, Perez Ortega, R, Bermudez Rattoni, F, Urrutia, A & Gutierrez, H 2020, ' Transcriptional, behavioural and biochemical profiling in the 3xTg-AD mouse model reveals a specific signature of amyloid deposition and functional decline in Alzheimer’s disease ', Frontiers in Neuroscience, vol. 14, 602642 . https://doi.org/10.3389/fnins.2020.602642

Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a58db09a5f1cf325b21e0b38260e4e
http://europepmc.org/articles/PMC7774037