Prenatal exposure to BPA alters the epigenome of the rat mammary gland and increases the propensity to neoplastic development.

Autor: Eugen Dhimolea, Perinaaz R Wadia, Tessa J Murray, Matthew L Settles, Jo D Treitman, Carlos Sonnenschein, Toshi Shioda, Ana M Soto

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e99800 (2014)

Exposure to environmental estrogens (xenoestrogens) may play a causal role in the increased breast cancer incidence which has been observed in Europe and the US over the last 50 years. The xenoestrogen bisphenol A (BPA) leaches from plastic food/beve

Externí odkaz: https://doaj.org/article/230442f2a5604ccd9b4feb913d75a799

Cancer as development gone awry: the case for bisphenol-A as a carcinogen

Autor: Ana M. Soto, Beverly S. Rubin, Carlos Sonnenschein, Perinaaz R. Wadia

Publikováno v: Journal of Developmental Origins of Health and Disease. 2:9-16

The discovery of a rare clear cell carcinoma of the vagina in young women gestationally exposed to the estrogen diethylstilbestrol (DES) lent empirical support to the hypothesis that prenatal exposure to xenoestrogens might cause cancer. This fact co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c0d0dbe33d1566bf023c3c0a58388e3
https://doi.org/10.1017/s2040174411000043

Perinatal Exposure to Bisphenol-A Alters Peripubertal Mammary Gland Development in Mice

Autor: Perinaaz R. Wadia, Caroline M. Markey, Enrique H. Luque, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto, Mónica Muñoz-de-Toro

Publikováno v: Endocrinology. 146:4138-4147

Developmental exposure to estrogenic chemicals induces morphological, functional, and behavioral anomalies associated with reproduction. Humans are exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials and plastic fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc0a52c4a4e3a03e058cfd246aa9032
https://doi.org/10.1210/en.2005-0340

Effects of low doses of bisphenol A on the metabolome of perinatally exposed CD-1 mice

Autor: Jérôme Molina, Beverly S. Rubin, Marie Tremblay-Franco, Jean-Pierre Cravedi, Ana M. Soto, Carlos Sonnenschein, Roselyne Gautier, Perinaaz R. Wadia, Nicolas J. Cabaton, Cécile Canlet, Daniel Zalko

Publikováno v: Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2013, 121 (5), pp.586-593. ⟨10.1289/ehp.1205588⟩
Environmental Health Perspectives 5 (121), 586-593. (2013)

International audience; BACKGROUND: Bisphenol A (BPA) is a well-known endocrine disruptor used to manufacture polycarbonate plastics and epoxy resins. Exposure of pregnant rodents to low doses of BPA results in pleiotropic effects in their offspring.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3294ec82d661362490ab4e43aebf995b
https://hal.inrae.fr/hal-02646392/document

Perinatal Exposure to Environmentally Relevant Levels of Bisphenol A Decreases Fertility and Fecundity in CD-1 Mice

Autor: Ana M. Soto, Michael H. Askenase, Perinaaz R. Wadia, Beverly S. Rubin, Gregory S. Whitt, Nicolas J. Cabaton, Carlos Sonnenschein, Andrew P. Tharp, Jennifer L. Gadbois, Daniel Zalko, Cheryl M. Schaeberle

Publikováno v: Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2011, 119 (4), pp.547-552. ⟨10.1289/ehp.1002559⟩
Environmental Health Perspectives 4 (119), 547-552. (2011)

International audience; BACKGROUND: Perinatal exposure to low-doses of bisphenol A (BPA) results in alterations in the ovary, uterus, and mammary glands and in a sexually dimorphic region of the brain known to be important for estrous cyclicity. OBJE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438529e23b06e1c1179efb70488eb027
https://hal.inrae.fr/hal-02649514/document