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Binary switch between adjacent marks in histone H3 directs productive transcription in estrogen-induced breast cancer cells upon cyclical creation of ROS

Autor: Di Santi A, G. Cernera, Ombra M, Marino I, Di Donato M, MIGLIACCIO, Antimo, Perillo B., CASTORIA, Gabriella

Inhibition of IKKalpha switches the antiapoptotic effect of estradiol to apoptotic effect in breast cancer cells. Thus estradiol in combination with IKKalpha inhibitors might be used in new trials for the therapy of breast cancers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::544b0dd01baba881d08f49c766b315b8
http://hdl.handle.net/11591/225152

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Estrogen Induces Looping Between Tumor Suppressor RIZ Gene Promoter 2 with Exon 9a

Autor: De Rosa, C, Di Zazzo, E, Todisco, E, Griffo, E, Spiniello, M, Ombra, M, Moncharmont, B, Perillo, B, MEDICI, Nicola, ABBONDANZA, Ciro

NTP1 Background: The dynamic intra- and inter-chromosomal links between specific loci contribute to the creation of cell type-specific gene expression profiles and to gene regulation during differentiation processes. Looping is implicated in bringing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::d4b790f84abf3a75bc7abe63659f845f
http://hdl.handle.net/11591/374980

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Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/Estrogen Receptor (Progesterone Receptor) complex assembly to a distal regulatory element and recruitment of Cyclin D1 to Its Own Gene Promoter

Autor: CICATIELLO L, ADDEO R, SASSO A, PETRIZZI VB, BORGO R, CANCEMI M, CAPORALI S, CARISTI S, SCAFOGLIO C, TETI D, BRESCIANI F, PERILLO B, WEISZ A., ALTUCCI, Lucia

Publikováno v: Molecular and cellular biology
24 (2004): 7260–7274. doi:10.1128/MCB.24.16.7260-7274.2004
info:cnr-pdr/source/autori:Cicatiello L, Addeo R, Sasso A, Altucci L, Belsito Petrizzi V, Borgo R, Cancemi M, Caporali S, Caristi S, Scafoglio C, Teti D, Bresciani F, Perillo B, Weisz A./titolo:Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun%2Fc-Fos%2FEstrogen Receptor (Progesterone Receptor) complex assembly to a distal regulatory element and recruitment of Cyclin D1 to Its Own Gene Promoter/doi:10.1128%2FMCB.24.16.7260-7274.2004/rivista:Molecular and cellular biology (Print)/anno:2004/pagina_da:7260/pagina_a:7274/intervallo_pagine:7260–7274/volume:24

Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G(1)-phase progression, which is thereby controlled by multiple regulatory factors, including nuclear receptors (NRs). Appropriate CCND1 gene activity is essential for n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::57b5a170a2796f4981546b22a0e56d32
https://publications.cnr.it/doc/45855

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Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene Expression in FRTL-5 Cells: II. DOWN-REGULATION BY v-K-ras ONCOGENE

Autor: Perillo, B., Tedesco, I., Laezza, C., Santillo, M., Romano, A., Aloj, S. M., Maurizio Bifulco

Publikováno v: The Journal of biological chemistry
270 (1995): 15237–15241.
info:cnr-pdr/source/autori:Perillo B, Tedesco I, Laezza C, Santillo M, Romano A, Aloj SM, Bifulco M./titolo:Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in FRTL-5 cells. II. Down-regulation by v-K-ras oncogene./doi:/rivista:The Journal of biological chemistry (Print)/anno:1995/pagina_da:15237/pagina_a:15241/intervallo_pagine:15237–15241/volume:270
Scopus-Elsevier

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and mRNA levels were significantly reduced in FRTL-5 cells transformed with the Kirsten-Moloney sarcoma virus (KiMol); these cells have lost thyrotropin dependence and express high le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0d823b4e531f987f5f076380cbb21724
http://hdl.handle.net/11588/644320

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