Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Perihan Nalbant"'
Autor:
Suchet Nanda, Abram Calderon, Arya Sachan, Thanh-Thuy Duong, Johannes Koch, Xiaoyi Xin, Djamschid Solouk-Stahlberg, Yao-Wen Wu, Perihan Nalbant, Leif Dehmelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Rho GTPases play a key role in the spatio-temporal coordination of cytoskeletal dynamics during cell migration. Here, we directly investigate crosstalk between the major Rho GTPases Rho, Rac and Cdc42 by combining rapid activity perturbation
Externí odkaz:
https://doaj.org/article/ab65325bb46f4cc898719fb2bad4d6f9
Autor:
Astrid Hensel, Paul Stahl, Lisa Moews, Lena König, Rutuja Patwardhan, Alexander Höing, Nina Schulze, Perihan Nalbant, Roland H. Stauber, Shirley K. Knauer
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104355- (2022)
Summary: The unique threonine protease Tasp1 impacts not only ordered development and cell proliferation but also pathologies. However, its substrates and the underlying molecular mechanisms remain poorly understood. We demonstrate that the unconvent
Externí odkaz:
https://doaj.org/article/aa24896ee8034a1982f47721b9ec1424
Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network
Autor:
Dominic Kamps, Johannes Koch, Victor O. Juma, Eduard Campillo-Funollet, Melanie Graessl, Soumya Banerjee, Tomáš Mazel, Xi Chen, Yao-Wen Wu, Stephanie Portet, Anotida Madzvamuse, Perihan Nalbant, Leif Dehmelt
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108467- (2020)
Summary: Local cell contraction pulses play important roles in tissue and cell morphogenesis. Here, we improve a chemo-optogenetic approach and apply it to investigate the signal network that generates these pulses. We use these measurements to deriv
Externí odkaz:
https://doaj.org/article/d234308fb6eb4026b4cc7e971dbde2f4
Autor:
Stefanie Jeruschke, Kay Jeruschke, Andrew DiStasio, Sinem Karaterzi, Anja K Büscher, Perihan Nalbant, Ludger Klein-Hitpass, Peter F Hoyer, Jürgen Weiss, Rolf W Stottmann, Stefanie Weber
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137043 (2015)
Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. R
Externí odkaz:
https://doaj.org/article/a717350a9c5046bfa105ee797e497590
Autor:
Stefanie Jeruschke, Anja Katrin Büscher, Jun Oh, Moin Ahson Saleem, Peter Friedrich Hoyer, Stefanie Weber, Perihan Nalbant
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55980 (2013)
Podocytes are highly differentiated kidney cells playing an important role in maintaining the glomerular filtration barrier. Particularly, the integrity of the actin cytoskeleton is crucial as cytoskeletal damage associated with foot process effaceme
Externí odkaz:
https://doaj.org/article/fa364d2f6988407fbb18addbf23019c3
Cells process information via signal networks that typically involve multiple components which are interconnected by feedback loops. The combination of acute optogenetic perturbations and microscopy-based fluorescent response readouts enables the dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa68e5e1d752a05519fd8f0f808e73b8
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85122083067
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85122083067
Autor:
Astrid Hensel, Paul Stahl, Lisa Moews, Lena König, Rutuja Patwardhan, Alexander Höing, Nina Schulze, Perihan Nalbant, Roland H. Stauber, Shirley K. Knauer
Publikováno v:
iScience. 25(6)
OA Förderung 2022 The unique threonine protease Tasp1 impacts not only ordered development and cell proliferation but also pathologies. However, its substrates and the underlying molecular mechanisms remain poorly understood. We demonstrate that the
Publikováno v:
Cell Reports
Optogenetic tuning reveals rho amplification-dependent dynamics of a cell contraction signal network
Autor:
Perihan Nalbant, Johannes Koch, Anotida Madzvamuse, Stéphanie Portet, Victor Ogesa Juma, Soumya Banerjee, Melanie Graessl, Tomáš Mazel, Dominic Kamps, Yao-Wen Wu, Leif Dehmelt, Eduard Campillo-Funollet, Xi Chen
Publikováno v:
Cell Reports
Cell Reports, Vol 33, Iss 9, Pp 108467-(2020)
Cell Reports, Vol 33, Iss 9, Pp 108467-(2020)
Summary Local cell contraction pulses play important roles in tissue and cell morphogenesis. Here, we improve a chemo-optogenetic approach and apply it to investigate the signal network that generates these pulses. We use these measurements to derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c54d2ac0339c01d466604db52df422
Autor:
Perihan Nalbant, Leif Dehmelt
Publikováno v:
Biological chemistryReferences. 399(8)
Cells need to process multifaceted external cues to steer their dynamic behavior. To efficiently perform this task, cells implement several exploratory mechanisms to actively sample their environment. In particular, cells can use exploratory actin-ba