Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin.

Autor: Sara Hägg, Mehran Salehpour, Peri Noori, Jesper Lundström, Göran Possnert, Rabbe Takolander, Peter Konrad, Stefan Rosfors, Arno Ruusalepp, Josefin Skogsberg, Jesper Tegnér, Johan Björkegren

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18248 (2011)

BACKGROUND: The stability of atherosclerotic plaques determines the risk for rupture, which may lead to thrombus formation and potentially severe clinical complications such as myocardial infarction and stroke. Although the rate of plaque formation m

Externí odkaz: https://doaj.org/article/6fab7ebcabe441bd889c779d333c205a

Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes.

Autor: Josefin Skogsberg, Jesper Lundström, Alexander Kovacs, Roland Nilsson, Peri Noori, Shohreh Maleki, Marina Köhler, Anders Hamsten, Jesper Tegnér, Johan Björkegren

Publikováno v: PLoS Genetics, Vol 4, Iss 3, p e1000036 (2008)

Despite the well-documented effects of plasma lipid lowering regimes halting atherosclerosis lesion development and reducing morbidity and mortality of coronary artery disease and stroke, the transcriptional response in the atherosclerotic lesion med

Externí odkaz: https://doaj.org/article/0628a124023e4368ae1442558fe68a23

Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation

Autor: Elizabeth Ing-Simmons, Gilad Silberberg, Georgios Papoutsoglou, Jesper Tegnér, Alicia G. Gómez-Valadés, Amanda G. Fisher, Isabel Ferreirós-Vidal, Ya Guo, Boris Lenhard, David Gomez-Cabrero, Sunjay Jude Fernandes, Vincenzo Lagani, Sonia Tarazona, Thomas L. Carroll, Gopuraja Dharmalingam, Peri Noori, Ioannis Tsamardinos, Ziwei Liang, Ana Conesa, Matthias Merkenschlager, Ali Mortazavi, Ricardo Ramirez, Lee Cooper, Tianyi Zhang

Publikováno v: PLoS Biology
PLOS BIOLOGY
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
PLoS Biology, Vol 17, Iss 4, p e2006506 (2019)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
Ferreirós-Vidal, I, Carroll, T, Zhang, T, Lagani, V, Ramirez, R N, Ing-Simmons, E, Gómez-Valadés, A G, Cooper, L, Liang, Z, Papoutsoglou, G, Dharmalingam, G, Guo, Y, Tarazona, S, Fernandes, S J, Noori, P, Silberberg, G, Fisher, A G, Tsamardinos, I, Mortazavi, A, Lenhard, B, Conesa, A, Tegner, J, Merkenschlager, M & Gomez-Cabrero, D 2019, ' Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation ', PLoS Biology, vol. 17, no. 4, e2006506 . https://doi.org/10.1371/journal.pbio.2006506

[EN] The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ecc069cb652279daf30a36ca2c2aa8
http://hdl.handle.net/10044/1/67971

Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin

Autor: Jesper Lundström, Stefan Rosfors, Arno Ruusalepp, Peri Noori, Josefin Skogsberg, Johan Björkegren, Mehran Salehpour, Göran Possnert, Peter Konrad, Sara Hägg, Jesper Tegnér, Rabbe Takolander

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18248 (2011)
PLoS ONE

Background: The stability of atherosclerotic plaques determines the risk for rupture, which may lead to thrombus formation and potentially severe clinical complications such as myocardial infarction and stroke. Although the rate of plaque formation m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce3c1be1c3a8756564538b3f25674aa
http://europepmc.org/articles/PMC3072386?pdf=render

Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study

Autor: Ulf Lockowandt, Björn Brinne, Sara Hägg, Anders Hamsten, Jesper Lundström, Johan Björkegren, Lee M. Kaplan, Eric E. Schadt, Jesper Tegnér, Ulf de Faire, Maria Bradshaw, Bruna Gigante, Ming-Mei Shang, Peter Konrad, Karin Leander, Vladimir B. Bajic, Angela Silveira, Roland Nilsson, Ann Samnegård, Rabbe Takolander, Peri Noori, Jan Liska, Shohreh Maleki, Anders Franco-Cereceda, Torbjörn Ivert, Stefan Rosfors, Josefin Skogsberg, Hua Zhong

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 5, Iss 12, p e1000754 (2009)

Environmental exposures filtered through the genetic make-up of each individual alter the transcriptional repertoire in organs central to metabolic homeostasis, thereby affecting arterial lipid accumulation, inflammation, and the development of coron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca213a6e1a7f1a37559fa26076b6b01f
https://pubmed.ncbi.nlm.nih.gov/19997623