Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Perfilyev, A A"'
Autor:
Charlotte Ling, Magdalena Vavakova, Bilal Ahmad Mir, Johanna Säll, Alexander Perfilyev, Melina Martin, Per-Anders Jansson, Cajsa Davegårdh, Olof Asplund, Ola Hansson, Allan Vaag, Emma Nilsson
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background A large proportion of skeletal muscle insulin resistance in type 2 diabetes (T2D) is caused by environmental factors. Methods By applying multiomics mRNA, microRNA (miRNA), and DNA methylation platforms in biopsies from 20 monozyg
Externí odkaz:
https://doaj.org/article/7246b0eb7bc44c71b1797a70ea93092c
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Type 2 diabetes (T2D) is the fastest growing non-infectious disease worldwide. Impaired insulin secretion from pancreatic beta-cells is a hallmark of T2D, but the mechanisms behind this defect are insufficiently characterized. Integrating mu
Externí odkaz:
https://doaj.org/article/c8d4693c758047b0adef87487a7425e7
Autor:
Tina Rönn, Jones K. Ofori, Alexander Perfilyev, Alexander Hamilton, Karolina Pircs, Fabian Eichelmann, Sonia Garcia-Calzon, Alexandros Karagiannopoulos, Hans Stenlund, Anna Wendt, Petr Volkov, Matthias B. Schulze, Hindrik Mulder, Lena Eliasson, Sabrina Ruhrmann, Karl Bacos, Charlotte Ling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 diabetes (T2D). In islets, 5,584 DNA methylation sites exhibit alterati
Externí odkaz:
https://doaj.org/article/19bed20de77c4fe59cb47f79626a6477
Autor:
A. M. Perfilyev, J. A. Rzaev
Publikováno v:
Инновационная медицина Кубани, Vol 0, Iss 3, Pp 5-12 (2023)
Objective: To compare the endovascular treatment results in patients with spinal arteriovenous malformations (AVM) based on the proposed algorithm. Materials and methods: We retrospectively analyzed the endovascular treatment results in 72 patients w
Externí odkaz:
https://doaj.org/article/529a42fc1f6f4afe9e41c8b9a8fa9270
Autor:
García-Calzón, Sonia, Schrader, Silja, Perfilyev, Alexander, Martinell, Mats, Ahlqvist, Emma, Ling, Charlotte
Publikováno v:
In Diabetes Research and Clinical Practice August 2023 202
Autor:
Ratika Sehgal, Alexander Perfilyev, Ville Männistö, Jyrki Ågren, Emma Nilsson, Pirjo Käkelä, Charlotte Ling, Vanessa D. de Mello, Jussi Pihlajamäki
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been sh
Externí odkaz:
https://doaj.org/article/b3570e4c3a1848e7a0cb3aba45d070cf
Autor:
dos Santos, Cristiane, Karagiannopoulos, Alexandros, Rafacho, Alex, Perfilyev, Alexander, Eliasson, Lena, Ling, Charlotte, Bacos, Karl
Publikováno v:
In Life Sciences 15 October 2022 307
Autor:
Sehgal, Ratika1 (AUTHOR), Perfilyev, Alexander2 (AUTHOR), Männistö, Ville3 (AUTHOR), Ågren, Jyrki4 (AUTHOR), Nilsson, Emma2 (AUTHOR), Käkelä, Pirjo5 (AUTHOR), Ling, Charlotte2 (AUTHOR), de Mello, Vanessa D.1 (AUTHOR), Pihlajamäki, Jussi1,6 (AUTHOR) jussi.pihlajamaki@uef.fi
Publikováno v:
Clinical Epigenetics. 2/11/2023, Vol. 15 Issue 1, p1-12. 12p.
Autor:
Josefine Jönsson, Kristina M. Renault, Alexander Perfilyev, Allan Vaag, Emma Malchau Carlsen, Kirsten Nørgaard, Paul W. Franks, Charlotte Ling
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 3, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/c0da57239df9461ea010b0aa80a861df
Autor:
Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 different
Externí odkaz:
https://doaj.org/article/1b6d5184407e4059bd119a1db2f0c8ba