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Characterization of six clinical drugs and dietary intervention in the non-obese CDAA-HFD mouse model of MASH and progressive fibrosis.

Autor: Nielsen MH; Pharmacology research, Gubra, Horsholm, Denmark., Nøhr-Meldgaard J; Pharmacology, Gubra, Horsholm, Denmark., Møllerhøj MB; Pharmacology, Gubra, Horsholm, Denmark., Oró D; Gubra, Hoersholm, Denmark., Pors SE; Histology, Gubra, Horsholm, Denmark., Andersen MW; Bioinformatics, Gubra, Horsholm, Denmark., Kamzolas I; WT/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Petsalaki E; Wellcome Genome Campus, European Bioinformatics Institute, United Kingdom., Vacca M; Department of Biochemistry and Systems Biology Centre, University of Cambridge, Cambridge, Cambs, United Kingdom., Harder LM; Research and Early Development, Novo Nordisk, Maaloev, Denmark., Perfield JW; Eli Lilly, Indianapolis, IN, United States., Veidal S; Obesity & NASH Pharmacology, Novo Nordisk, Denmark., Hansen HH; Pharmacology, Gubra, Hoersholm, Denmark., Feigh M; Gubra, Hoersholm, Denmark.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD).

Autor: Vacca M; TVP Lab, WT/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. michele.vacca@uniba.it.; Interdisciplinary Department of Medicine, University of Bari 'Aldo Moro', Bari, Italy. michele.vacca@uniba.it.; Laboratory of Liver Metabolism and MASLD, Roger Williams Institute of Hepatology, London, UK. michele.vacca@uniba.it., Kamzolas I; TVP Lab, WT/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., Harder LM; Research and Early Development, Novo Nordisk A/S, Måløv, Copenhagen, Denmark., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Trautwein C; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Hatting M; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Ross T; Internal Medicine research Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Bernardo B; Internal Medicine research Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Oldenburger A; CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany., Hjuler ST; Research and Early Development, Novo Nordisk A/S, Måløv, Copenhagen, Denmark., Ksiazek I; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Lindén D; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca BioPharmaceuticals R&D, Gothenburg, Sweden.; Division of Endocrinology, Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Schuppan D; Institute of Translational Immunology and Research Center for Immunotherapy, Johannes Gutenberg University Medical Center, Mainz, Germany., Rodriguez-Cuenca S; TVP Lab, WT/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Tonini MM; Luxembourg Institute of Health, Translational Medicine Operations Hub, Dudelange, Luxembourg., Castañeda TR; R&D Diabetes & Portfolio Innovation and Excellence, Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt, Germany., Kannt A; R&D Diabetes, Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Fraunhofer Innovation Center TheraNova and Goethe University, Frankfurt, Germany., Rodrigues CMP; Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Cockell S; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Govaere O; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Daly AK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Allison M; Liver Unit, Cambridge University Hospitals NHS Foundation Trust & Cambridge NIHR Biomedical Research Centre, Cambridge, UK., Honnens de Lichtenberg K; Research and Early Development, Novo Nordisk A/S, Måløv, Copenhagen, Denmark., Kim YO; Institute of Translational Immunology and Research Center for Immunotherapy, Johannes Gutenberg University Medical Center, Mainz, Germany., Lindblom A; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca BioPharmaceuticals R&D, Gothenburg, Sweden., Oldham S; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca BioPharmaceuticals R&D, Gaithersburg, MD, USA., Andréasson AC; Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca BioPharmaceuticals R&D, Gothenburg, Sweden., Schlerman F; Inflammation and Immunology Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Marioneaux J; Fleur De Lis Holdings 10201 Dakins Dr. Richmond, Richmond, VA, USA., Sanyal A; Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA., Afonso MB; Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Younes R; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany., Amano Y; Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Friedman SL; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang S; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bhattacharya D; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Simon E; Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany., Paradis V; Department of Imaging and Pathology, Université Paris Diderot and Hôpital Beaujon, Paris, France., Burt A; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK., Grypari IM; Department of Pathology, Aretaeion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Davies S; Department of Cellular Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Driessen A; Department of Pathology, Antwerp University Hospital, Edegem, Belgium.; Department of Molecular Imaging, Pathology, Radiotherapy, Oncology. Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium., Yashiro H; Research, Takeda Pharmaceuticals Company Limited, Cambridge, MA, USA., Pors S; Gubra, Hoersholm, Denmark., Worm Andersen M; Gubra, Hoersholm, Denmark., Feigh M; Gubra, Hoersholm, Denmark., Yunis C; Pfizer, Inc.; Internal Medicine and Hospital, Pfizer Research and Development, Lake Mary, FL, USA., Bedossa P; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; LiverPat, Paris, France., Stewart M; Mary Lyon Centre, MRC Harwell, Harwell Campus, Oxford, UK., Cater HL; Mary Lyon Centre, MRC Harwell, Harwell Campus, Oxford, UK., Wells S; Mary Lyon Centre, MRC Harwell, Harwell Campus, Oxford, UK., Schattenberg JM; Department of Internal Medicine II, Saarland University Medical Centre, Homburg, Germany., Anstee QM; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK., Tiniakos D; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. Dina.Tiniakos@newcastle.ac.uk.; Department of Pathology, Aretaeion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Dina.Tiniakos@newcastle.ac.uk., Perfield JW; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA. Perfield_james_w@lilly.com., Petsalaki E; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK. petsalaki@ebi.ac.uk., Davidsen P; Research and Early Development, Novo Nordisk A/S, Måløv, Copenhagen, Denmark. pkdavidsen@gmail.com.; Ferring Pharmaceuticals A/S, International PharmaScience Center, Copenhagen, Denmark. pkdavidsen@gmail.com., Vidal-Puig A; TVP Lab, WT/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. ajv22@medschl.cam.ac.uk.; Centro de Investigacion Principe Felipe, Valencia, Spain. ajv22@medschl.cam.ac.uk.

Publikováno v: Nature metabolism [Nat Metab] 2024 Jun; Vol. 6 (6), pp. 1178-1196. Date of Electronic Publication: 2024 Jun 12.