Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple Sclerosis.

Autor: Perez-Paramo YX; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Dufield D; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Veeramachaneni R; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Parkhurst E; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Harp C; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Ramesh A; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Winger RC; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Cross AH; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Gelfand JM; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Bar-Or A; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Mathews WR; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.)., Anania VG; Department of Translational Medicine, Genentech, Inc., South San Francisco, California (Y.X.P.-P., C.H., A.R., R.C.W., W.R.M., V.G.A.); KCAS Bioanalytical Sciences, Olathe, Kansas (D.D., R.V., E.P.); Washington University School of Medicine, St Louis, Missouri (A.H.C.); University of California, San Francisco, California (J.M.G.); and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (A.B.-O.) anania.veronica@gene.com.

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2024 Feb 15; Vol. 105 (3), pp. 121-130. Date of Electronic Publication: 2024 Feb 15.

Impact of Genetic Variants in the Nicotine Metabolism Pathway on Nicotine Metabolite Levels in Smokers.

Autor: Perez-Paramo YX; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Watson CJW; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Chen G; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Thomas CE; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Adams-Haduch J; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Wang R; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Singapore Eye Research Institute, Singapore, Singapore.; Eye Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Koh WP; Health Services and Systems Research, Duke-NUS Medical School Singapore, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Nelson HH; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Lazarus P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.

Publikováno v: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2023 Jan 09; Vol. 32 (1), pp. 54-65.

NUSAP1 and PCLAF ( KIA0101 ) Downregulation by Neoadjuvant Therapy is Associated with Better Therapeutic Outcomes and Survival in Breast Cancer.

Autor: Magallanes-Garza GI; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.; Tecnologico de Monterrey, Servicio de Ginecologia y Obstetricia, Tec Salud, Monterrey, Mexico.; Tecnologico de Monterrey, Centro de Cancer de Mama, Hospital Zambrano Hellion, San Pedro Garza Garcia, Mexico., Santuario-Facio SK; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico., Lira-Albarrán S; Tecnologico de Monterrey, The Institute for Obesity Research, Monterrey, Mexico., Varela-Varela AF; Universidad Autonoma de Coahuila, Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreon, Torreon, Mexico., Cardona-Huerta S; Tecnologico de Monterrey, Direccion Nacional de Investigacion Clinica TecSalud, Monterrey, Mexico.; Instituto Mexicano Del Seguro Social, Unidad Medica de Alta Especialidad No. 25, Monterrey, Mexico., Ruiz-Flores P; Universidad Autonoma de Coahuila, Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreon, Torreon, Mexico., Haro-Santa-Cruz J; Universidad Autonoma de Coahuila, Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreon, Torreon, Mexico., Perez-Paramo YX; Washington State University, Pharmaceutical Sciences Department, College of Pharmacy Spokane, WA, USA., Gomez-Macias GS; Tecnologico de Monterrey, Centro de Cancer de Mama, Hospital Zambrano Hellion, San Pedro Garza Garcia, Mexico.; Universidad Autonoma de Nuevo Leon, Facultad de Medicina, Monterrey, Mexico., Davila-Gonzalez D; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.; Tecnologico de Monterrey, Direccion Nacional de Investigacion Clinica TecSalud, Monterrey, Mexico., Valero-Gomez J; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico., Borrego-Soto G; University of Texas at Austin, Department of Molecular Biosciences, Austin, TX, USA., Rojas-Martinez A; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.; Tecnologico de Monterrey, The Institute for Obesity Research, Monterrey, Mexico.; Universidad Autonoma de Nuevo Leon, CIDICS, Monterrey, Mexico., Ortiz-Lopez R; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Monterrey, Mexico.; Tecnologico de Monterrey, The Institute for Obesity Research, Monterrey, Mexico.; Universidad Autonoma de Nuevo Leon, CIDICS, Monterrey, Mexico.

Publikováno v: Journal of oncology [J Oncol] 2022 Nov 28; Vol. 2022, pp. 6001947. Date of Electronic Publication: 2022 Nov 28 (Print Publication: 2022).

Pharmacogenetics factors influencing smoking cessation success; the importance of nicotine metabolism.

Autor: Perez-Paramo YX; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA., Lazarus P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

Publikováno v: Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2021 Mar; Vol. 17 (3), pp. 333-349. Date of Electronic Publication: 2020 Dec 29.

Nicotine- N '-Oxidation by Flavin Monooxygenase Enzymes.

Autor: Perez-Paramo YX; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Chen G; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Ashmore JH; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Watson CJW; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Nasrin S; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington., Adams-Haduch J; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Wang R; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Gao YT; Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Koh WP; Duke-NUS Medical School Singapore, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Lazarus P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington. phil.lazarus@wsu.edu.

Publikováno v: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2019 Feb; Vol. 28 (2), pp. 311-320. Date of Electronic Publication: 2018 Oct 31.