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Potential Opportunities and Challenges of Deploying Next Generation Sequencing and CRISPR-Cas Systems to Support Diagnostics and Surveillance Towards Malaria Control and Elimination in Africa

Autor: Lyimo, B. M., Popkin-Hall, Z. R., Giesbrecht, D. J., Mandara, C. I., Madebe, R. A., Bakari, C., Pereus, D., Seth, M. D., Ngamba, R. M., Mbwambo, R. B., MacInnis, B., Mbwambo, D., Garimo, I., Chacky, F., Aaron, S., Lusasi, A., Molteni, F., Njau, R., Cunningham, J. A., Lazaro, S., Mohamed, A., Juliano, J. J., Bailey, J. A., Ishengoma, D. S.

Publikováno v: Frontiers in cellular and infection microbiology. 12

Recent developments in molecular biology and genomics have revolutionized biology and medicine mainly in the developed world. The application of next generation sequencing (NGS) and CRISPR-Cas tools is now poised to support endemic countries in the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa1b53e5fa02e67411d4d9e32333818
https://pubmed.ncbi.nlm.nih.gov/35909968

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Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity.

Autor: Lyimo BM; National Institute for Medical Research, Dar es Salaam, Tanzania.; Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania., Bakari C; National Institute for Medical Research, Dar es Salaam, Tanzania., Popkin-Hall ZR; University of North Carolina, Chapel Hill, NC, USA., Giesbrecht DJ; Brown University, Providence, RI, USA., Seth MD; National Institute for Medical Research, Dar es Salaam, Tanzania., Pereus D; National Institute for Medical Research, Dar es Salaam, Tanzania.; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Moshi R; National Institute for Medical Research, Dar es Salaam, Tanzania., Boniface R; National Institute for Medical Research, Dar es Salaam, Tanzania.; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Mandara CI; National Institute for Medical Research, Dar es Salaam, Tanzania., Madebe R; National Institute for Medical Research, Dar es Salaam, Tanzania., Juliano JJ; University of North Carolina, Chapel Hill, NC, USA., Bailey JA; Brown University, Providence, RI, USA., Ishengoma DS; National Institute for Medical Research, Dar es Salaam, Tanzania.; Harvard T.H Chan School of Public Health, Boston, MA, USA.; Faculty of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jan 23. Date of Electronic Publication: 2024 Jan 23.