Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Autor: Perera, Rushika, Son, J, Lyssiotis, CA, Ying, H, Wang, X, Hua, S, Ligorio, M, Perera, RM, Ferrone, CR, Mullarky, E, Shyh-Chang, N

Publikováno v: Perera, Rushika; Son, J; Lyssiotis, CA; Ying, H; Wang, X; Hua, S; et al.(2013). Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3n3185s8

Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes. Indeed, the spectrum of glutamine-dependent tumours an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::1f7229fac061824092f7f398f5d95c33
http://www.escholarship.org/uc/item/3n3185s8

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A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.

Autor: Berquez M, Li AL, Luy MA, Venida AC, O'Loughlin T, Rademaker G, Barpanda A, Hu J, Yano J, Wiita A, Gilbert LA, Bruno PM, Perera RM

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.

Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology.

Autor: Settembre C; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy. settembre@tigem.it.; Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. settembre@tigem.it., Perera RM; Department of Anatomy, University of California at San Francisco, San Francisco, CA, USA. rushika.perera@ucsf.edu.; Department of Pathology, University of California at San Francisco, San Francisco, CA, USA. rushika.perera@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA. rushika.perera@ucsf.edu.

Publikováno v: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2024 Mar; Vol. 25 (3), pp. 223-245. Date of Electronic Publication: 2023 Nov 24.

Functional characterization of Alzheimer's disease genetic variants in microglia.

Autor: Yang X; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Wen J; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Yang H; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Jones IR; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Zhu X; Helen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York City, NY, USA., Liu W; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA., Li B; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Clelland CD; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Luo W; Helen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York City, NY, USA., Wong MY; Helen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York City, NY, USA., Ren X; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Cui X; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Song M; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Liu H; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Chen C; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Eng N; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Ravichandran M; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA., Sun Y; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Lee D; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Van Buren E; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Jiang MZ; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Chan CSY; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Ye CJ; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA., Perera RM; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Gan L; Helen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York City, NY, USA., Li Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. yun_li@med.unc.edu.; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA. yun_li@med.unc.edu.; Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA. yun_li@med.unc.edu., Shen Y; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. yin.shen@ucsf.edu.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. yin.shen@ucsf.edu.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. yin.shen@ucsf.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Oct; Vol. 55 (10), pp. 1735-1744. Date of Electronic Publication: 2023 Sep 21.