Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry.

Autor: Asiimwe IG; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Blockman M; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Cavallari LH; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL., Cohen K; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Cupido C; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; Victoria Hospital Internal Medicine Research Initiative, Victoria Hospital Wynberg, Cape Town, South Africa., Dandara C; Division of Human Genetics, Department of Pathology, Pharmacogenomics and Drug Metabolism Research Group, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Davis BH; Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL., Jacobson B; Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa., Johnson JA; Division of Pharmaceutics and Pharmacology, Center for Clinical and Translational Science, College of Medicine, The Ohio State University, Columbus, OH., Lamorde M; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda., Limdi NA; Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL., Morgan J; Metro Health Services, Western Cape Department of Health and Wellness, Cape Town, South Africa.; Division of Family Medicine, Department of Family, Community and Emergency Care, University of Cape Town, Cape Town, South Africa., Mouton JP; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Muyambo S; Department of Biological Sciences and Ecology, Faculty of Science, University of Zimbabwe, Harare, Zimbabwe., Nakagaayi D; Department of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda., Ndadza A; Division of Human Genetics, Department of Pathology, Pharmacogenomics and Drug Metabolism Research Group, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Okello E; Department of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda., Perera MA; Department of Pharmacology, Center for Pharmacogenomics, Northwestern University, Chicago, IL., Schapkaitz E; Department of Molecular Medicine and Hematology, Charlotte Maxeke Johannesburg Academic Hospital National Health Laboratory System Complex and University of Witwatersrand, Johannesburg, South Africa., Sekaggya-Wiltshire C; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda., Semakula JR; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda., Tatz G; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Waitt C; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda., Yang G; Department of Pharmacology, Center for Pharmacogenomics, Northwestern University, Chicago, IL.; Genetics Group, Center for Applied Bioinfomatics, St. Jude Children's Research Hospital, Memphis, TN., Zhang EJ; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Jorgensen AL; Department of Health Data Science, Institute of Population Health Sciences, University of Liverpool, Liverpool, United Kingdom., Pirmohamed M; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.

Publikováno v: Blood advances [Blood Adv] 2024 Oct 22; Vol. 8 (20), pp. 5248-5261.

Investigation of genomic and transcriptomic risk factors in clopidogrel response in African Americans.

Autor: Yang G; Department of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL., Alarcon C; Department of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL., Chanfreau C; VA Salt Lake City Heath Care System, Salt Lake City, UT., Lee NH; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Friedman P; Department of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL., Nutescu E; Department of Pharmacy Practice and Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois Chicago, College of Pharmacy, Chicago, IL., Tuck M; Washington DC VA Medical Center, Washington, DC and The George Washington University, Washington, DC., O'Brien T; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Gong L; Department of Biomedical Data Science, Stanford University, Stanford, CA., Klein TE; Department of Biomedical Data Science and Department of Medicine, Stanford University, Stanford, CA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Tsao PS; VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA., Meltzer DO; Section of Hospital Medicine, Department of Medicine, University of Chicago, Chicago, IL., Tuteja S; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Perera MA; Department of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Dec 07. Date of Electronic Publication: 2023 Dec 07.

Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation.

Autor: Hernandez W; University of Chicago, Department of Medicine, Section of Genetic Medicine, Section of Cardiology, Chicago, IL, USA., Danahey K; University of Chicago, Center for Personalized Therapeutics, Chicago, IL, USA.; University of Chicago, Center for Research Informatics, Chicago, IL, USA., Pei X; University of Chicago, Center for Personalized Therapeutics, Chicago, IL, USA.; University of Chicago, Department of Pathology, UChicago Advanced Technology Clinical Pharmacogenomics Laboratory, Chicago, IL, USA., Yeo KJ; University of Chicago, Department of Pathology, UChicago Advanced Technology Clinical Pharmacogenomics Laboratory, Chicago, IL, USA., Leung E; University of Chicago, Department of Pathology, UChicago Advanced Technology Clinical Pharmacogenomics Laboratory, Chicago, IL, USA.; University of Southern California, Keck School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA., Volchenboum SL; University of Chicago, Center for Research Informatics, Chicago, IL, USA., Ratain MJ; University of Chicago, Center for Personalized Therapeutics, Chicago, IL, USA.; University of Chicago, Department of Medicine, Chicago, IL, USA.; University of Chicago, Committee on Clinical Pharmacology and Pharmacogenomics, Chicago, IL, USA., Meltzer DO; University of Chicago, Department of Medicine, Chicago, IL, USA., Stranger BE; University of Chicago, Department of Medicine, Section of Genetic Medicine, Section of Cardiology, Chicago, IL, USA.; University of Chicago, Institute of Genomics and Systems Biology, and Center for Data Intensive Science, Chicago, IL, USA., Perera MA; Northwestern University, Department of Pharmacology, Chicago, IL, USA., O'Donnell PH; University of Chicago, Center for Personalized Therapeutics, Chicago, IL, USA. podonnel@medicine.bsd.uchicago.edu.; University of Chicago, Department of Medicine, Chicago, IL, USA. podonnel@medicine.bsd.uchicago.edu.; University of Chicago, Committee on Clinical Pharmacology and Pharmacogenomics, Chicago, IL, USA. podonnel@medicine.bsd.uchicago.edu.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2020 Feb; Vol. 20 (1), pp. 126-135. Date of Electronic Publication: 2019 Sep 11.

Local Ancestry-Informed Candidate Pathway Analysis of Warfarin Stable Dose in Latino Populations.

Autor: Steiner HE; Data Science Institute, University of Arizona, Tucson, Arizona, USA.; Department of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson, Arizona, USA., Carrion KC; Research Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, USA., Giles JB; Department of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson, Arizona, USA., Lima AR; Research Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, USA., Yee K; Banner University Medical Center-Tucson, Tucson, Arizona, USA., Sun X; Department of Biostatistics, University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USA., Cavallari LH; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Perera MA; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Duconge J; Department of Pharmaceutical Sciences, University of Puerto Rico School of Pharmacy, Medical Sciences Campus, San Juan, Puerto Rico, USA., Karnes JH; Department of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson, Arizona, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Mar; Vol. 113 (3), pp. 680-691. Date of Electronic Publication: 2022 Dec 08.

Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs.

Autor: Garofano K; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Rashid K; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Smith M; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Brantner C; GW Nanofabrication and Imaging Center, The George Washington University, Washington, DC, 20037, USA., Suwunnakorn S; Department of Microbiology Immunology and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA., Diemert D; Department of Medicine, George Washington University, Washington, DC, 20037, USA., Gordon O; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Horvath A; Department of Biochemistry and Molecular Medicine, George Washington University, Washington, DC, 20037, USA., Khan S; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Popratiloff A; GW Nanofabrication and Imaging Center, The George Washington University, Washington, DC, 20037, USA., Rhim J; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Sidahmed A; Department of Medicine, George Washington University, Washington, DC, 20037, USA., Maggirwar SB; Department of Microbiology Immunology and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA., O'Brien TJ; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA., Perera MA; Department of Pharmacology and Center for Pharmacogenomics, Northwestern University, Chicago, IL, 60611, USA., Lee NH; Department of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA. nhlee@gwu.edu.; GW Cancer Center, George Washington University, Washington, DC, 20037, USA. nhlee@gwu.edu.

Publikováno v: Scientific reports [Sci Rep] 2023 Feb 17; Vol. 13 (1), pp. 2864. Date of Electronic Publication: 2023 Feb 17.