Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands.

Autor: Petronilho EC; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Pedrote MM; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Marques MA; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Passos YM; Faculty of Pharmacy, Federal University of Rio de Janeiro Rio de Janeiro Brazil., Mota MF; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Jakobus B; Modal Informática Ltda Almeida Godinho, 19, 304 Rio de Janeiro RJ 22741-140 Brazil., de Sousa GDS; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Pereira da Costa F; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Felix AL; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Ferretti GDS; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Almeida FP; National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil., Cordeiro Y; Faculty of Pharmacy, Federal University of Rio de Janeiro Rio de Janeiro Brazil., Vieira TCRG; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., de Oliveira GAP; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br., Silva JL; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br jerson@bioqmed.ufrj.br.

Publikováno v: Chemical science [Chem Sci] 2021 Apr 26; Vol. 12 (21), pp. 7334-7349. Date of Electronic Publication: 2021 Apr 26.

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