Limonene, a citrus monoterpene, non-complexed and complexed with hydroxypropyl-β-cyclodextrin attenuates acute and chronic orofacial nociception in rodents: Evidence for involvement of the PKA and PKC pathway.

Autor: Pereira EWM; Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil., Heimfarth L; Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão, SE, Brazil., Santos TK; Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão, SE, Brazil., Passos FRS; Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil., Siqueira-Lima P; College of Science and Technology, Feira de Santana, BA, Brazil., Scotti L; Federal University of Paraiba, João Pessoa, PB, Brazil., Scotti MT; Federal University of Paraiba, João Pessoa, PB, Brazil., Almeida JRGDS; Federal University of Vale do São Francisco, Petrolina, PE, Brazil., Campos AR; Experimental Biology Centre (NUBEX). University of Fortaleza, Fortaleza, CE, Brazil., Coutinho HDM; Regional University of Cariri, Crato-E, Brazil. Electronic address: hdmcoutinho@gmail.com., Martin P; Univ Artois, UniLaSalle, Unité Transformations & Agroressources, Béthune, France., Quintans-Júnior LJ; Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil., Quintans JSS; Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Feb; Vol. 96, pp. 153893. Date of Electronic Publication: 2021 Dec 18.

Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: Involvement of NFκB and p38 MAPK pathways.

Autor: Santos Passos FR; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil; Health Sciences Graduate Program, Brazil., Pereira EWM; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil; Health Sciences Graduate Program, Brazil., Heimfarth L; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil., Monteiro BS; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil., Barbosa Gomes de Carvalho YM; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil., Siqueira-Lima PS; College of Science and Technology, Feira de Santana, BA, Brazil., Melo Coutinho HD; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Antunes de Souza Araújo A; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Brazil., Guedes da Silva Almeida JR; Colegiado de Farmácia, Universidade Federal do Vale do São Francisco, Petrolina, PE, Brazil., Barreto RSS; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil., Picot L; La Rochelle Université, UMRi CNRS 7266 LIENSs, 17042, La Rochelle, France., Quintans-Júnior LJ; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil; Health Sciences Graduate Program, Brazil., Quintans JSS; Laboratory of Neurosciences and Pharmacological Assays (LANEF- Laboratório de Neurociências e Ensaios Farmacológicos), Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil; Health Sciences Graduate Program, Brazil. Electronic address: jullyanaquintans@gmail.com.

Publikováno v: Neuropharmacology [Neuropharmacology] 2021 Mar 15; Vol. 186, pp. 108395. Date of Electronic Publication: 2021 Jan 28.

Dereplication and quantification of the ethanol extract of Miconia albicans (Melastomaceae) by HPLC-DAD-ESI-/MS/MS, and assessment of its anti-hyperalgesic and anti-inflammatory profiles in a mice arthritis-like model: Evidence for involvement of TNF-α, IL-1β and IL-6.

Autor: Quintans-Júnior LJ; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil. Electronic address: lucindojr@gmail.com., Gandhi SR; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil., Passos FRS; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil., Heimfarth L; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil., Pereira EWM; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil., Monteiro BS; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil., Dos Santos KS; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil., Duarte MC; Department of Pharmacy, Federal University of Sergipe (UFS), São Cristóvão, SE, 49100-000 Brazil., Abreu LS; Nucleus for Characterization and Analysis, Department of Pharmaceutical Sciences, Health Science Center, Federal University of Paraíba (UFPB), João Pessoa, Brazil., Nascimento YM; Nucleus for Characterization and Analysis, Department of Pharmaceutical Sciences, Health Science Center, Federal University of Paraíba (UFPB), João Pessoa, Brazil., Tavares JF; Nucleus for Characterization and Analysis, Department of Pharmaceutical Sciences, Health Science Center, Federal University of Paraíba (UFPB), João Pessoa, Brazil., Silva MS; Nucleus for Characterization and Analysis, Department of Pharmaceutical Sciences, Health Science Center, Federal University of Paraíba (UFPB), João Pessoa, Brazil., Menezes IRA; Graduate Program of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceará, Brazil., Coutinho HDM; Graduate Program of Biological Chemistry, Regional University of Cariri (URCA), Crato, Ceará, Brazil., Lima ÁAN; Department of Pharmacy, Health Sciences Center, Universidade Federal Do Rio Grande Do Norte (UFRN), Rio Grande Do Norte (RN), Natal, 59012-570, Brazil., Zengin G; Science Faculty, Department of Biology, Selcuk University, Konya, Turkey., Quintans JSS; Multiuser Health Center Facility (CMulti-Saúde), Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Depatment of Pharmacy, Federal University of Sergipe, São Cristóvão-SE, CEP 49.100-000, Brazil. Electronic address: jullyana@pq.cnpq.br.

Publikováno v: Journal of ethnopharmacology [J Ethnopharmacol] 2020 Aug 10; Vol. 258, pp. 112938. Date of Electronic Publication: 2020 May 05.

Indole-3-guanylhydrazone hydrochloride mitigates long-term cognitive impairment in a neonatal sepsis model with involvement of MAPK and NFκB pathways.

Autor: Heimfarth L; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address: luahei@yahoo.com.br., Carvalho AMS; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Quintans JSS; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Pereira EWM; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Lima NT; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Bezerra Carvalho MT; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Barreto RSS; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Moreira JCF; Biochemistry Department, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., da Silva-Júnior EF; Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Alagoas, Brazil., Schmitt M; Département de Pharmacochimie Moléculaire, Centre de Neurochimie, Strasbourg University, Strasbourg, France., Bourguignon JJ; Département de Pharmacochimie Moléculaire, Centre de Neurochimie, Strasbourg University, Strasbourg, France., de Aquino TM; Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Alagoas, Brazil., Araújo-Júnior JX; Laboratory of Medicinal Chemistry, Institure of Pharmaceutical Sciences, Federal University of Alagoas, Maceio, Alagoas, Brazil., Quintans-Júnior LJ; Laboratory of Neuroscience and Pharmacological Assay (LANEF), Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address: lucindojr@gmail.com.

Publikováno v: Neurochemistry international [Neurochem Int] 2020 Mar; Vol. 134, pp. 104647. Date of Electronic Publication: 2019 Dec 23.

Anti-hyperalgesic effect of (-)-α-bisabolol and (-)-α-bisabolol/β-Cyclodextrin complex in a chronic inflammatory pain model is associated with reduced reactive gliosis and cytokine modulation.

Autor: Fontinele LL; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Heimfarth L; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Pereira EWM; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Rezende MM; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Lima NT; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Barbosa Gomes de Carvalho YM; Department of Pharmacy. Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil., Afonso de Moura Pires E; Faculdade de Enfermagem Nova Esperança (FACENE), Brazil., Guimarães AG; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Bezerra Carvalho MT; Multiuser Health Center Facility (CMulti-Saúde), Brazil., de Souza Siqueira Barreto R; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Campos AR; Experimental Biology Center, University of Fortaleza, Fortaleza, Ceará, Brazil., Antoniolli AR; Multiuser Health Center Facility (CMulti-Saúde), Brazil., Antunes de Souza Araújo A; Department of Pharmacy. Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil., Quintans-Júnior LJ; Multiuser Health Center Facility (CMulti-Saúde), Brazil., de Souza Siqueira Quintans J; Multiuser Health Center Facility (CMulti-Saúde), Brazil. Electronic address: jullyanaquintans@gmail.com.

Publikováno v: Neurochemistry international [Neurochem Int] 2019 Dec; Vol. 131, pp. 104530. Date of Electronic Publication: 2019 Aug 16.