Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Pere Puigserver"'
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114484- (2024)
Summary: The inherent ability of melanoma cells to alter the differentiation-associated transcriptional repertoire to evade treatment and facilitate metastatic spread is well accepted and has been termed phenotypic switching. However, how these facet
Externí odkaz:
https://doaj.org/article/321247dfe0044b04aa3609d458c559ac
Autor:
Jiaxin Liang, Deyang Yu, Chi Luo, Christopher Bennett, Mark Jedrychowski, Steve P. Gygi, Hans R. Widlund, Pere Puigserver
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract While targeted treatment against BRAF(V600E) improve survival for melanoma patients, many will see their cancer recur. Here we provide data indicating that epigenetic suppression of PGC1α defines an aggressive subset of chronic BRAF-inhibit
Externí odkaz:
https://doaj.org/article/c2657c434fc34c79b1541bfc5979b66b
Autor:
Eduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench, Pere Puigserver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mitochondrial oxidative phosphorylation produces ATP and is an important source for cellular energy equivalents. Here the authors perform a cell-based screen to identify genes that alleviate perturbed mitochondrial complex I function and identify mal
Externí odkaz:
https://doaj.org/article/6b5c34283bc544b78083839339684cb7
Publikováno v:
Nature Reviews Molecular Cell Biology. 23:817-835
Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and survival in the changing environment by adjusting the respiratory capacity of mitochondria. These mitochondrial responses ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dba1e711f988c796cfddcaefd372af
https://doi.org/10.1038/s41580-022-00506-6
https://doi.org/10.1038/s41580-022-00506-6
Figure S1 from Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency
Autor:
Pere Puigserver, Piotr Sicinski, Andrew X. Zhu, Marc Bilodeau, Amitabh Srivastava, Lipika Goyal, Clint D.J. Tavares, Elizabeth A. Perry, Maximilian Hatting, Kfir Sharabi, Jiaxin Liang, Chi Luo
Gene expression profiles of liver or HCC derived from lean and obese/diabetic mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de6427839f6ff7f70e1d602fe4c8f5c
https://doi.org/10.1158/0008-5472.22426626.v1
https://doi.org/10.1158/0008-5472.22426626.v1
Autor:
Pere Puigserver, Piotr Sicinski, Andrew X. Zhu, Marc Bilodeau, Amitabh Srivastava, Lipika Goyal, Clint D.J. Tavares, Elizabeth A. Perry, Maximilian Hatting, Kfir Sharabi, Jiaxin Liang, Chi Luo
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8463473c89916f7ecf4aadc720527931
https://doi.org/10.1158/0008-5472.22426614.v1
https://doi.org/10.1158/0008-5472.22426614.v1
Autor:
Pere Puigserver, Piotr Sicinski, Andrew X. Zhu, Marc Bilodeau, Amitabh Srivastava, Lipika Goyal, Clint D.J. Tavares, Elizabeth A. Perry, Maximilian Hatting, Kfir Sharabi, Jiaxin Liang, Chi Luo
Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c085328c4d42deb8b8d1c57414554f
https://doi.org/10.1158/0008-5472.c.6512409.v1
https://doi.org/10.1158/0008-5472.c.6512409.v1
Autor:
Geoffrey D. Girnun, Laszlo Boros, Pere Puigserver, Francesca Vazquez, Scott B. Vafai, Hong-bin Fang, William Twaddel, Lihui Ou, Ruby E. Dewi, Bor Jang Hwang, Kavita Bhalla
PDF file - 395K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787b1ff460736b56bba338e0a9dd50cc
https://doi.org/10.1158/0008-5472.22388282
https://doi.org/10.1158/0008-5472.22388282
PDF file - 344KB, Supplementary Figure 1. A, Levels of PGC1alpha target genes in PGC1α-suppressed tumors. Supplementary Figure 2. HIF-1alpha protein levels and glycolytic target genes in PGC1α negative and positive melanoma cells after exposure to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1513af33bf84d3c957d323fbf36a65ba
https://doi.org/10.1158/0008-5472.22399940
https://doi.org/10.1158/0008-5472.22399940
Autor:
Conor T. Ronayne, Christopher F. Bennett, Elizabeth A. Perry, Noa Kantorovic, Pere Puigserver
Publikováno v:
bioRxiv
Mitochondrial diseases are a group of disorders defined by defects in oxidative phosphorylation caused by nuclear- or mitochondrial-encoded gene mutations. A main cellular phenotype of mitochondrial disease mutations are redox imbalances and inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279c8ed5d93387050510f66d2a0df81f
https://europepmc.org/articles/PMC10028993/
https://europepmc.org/articles/PMC10028993/