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Akademický článek

Transmembrane signaling by a synthetic receptor in artificial cells

Autor: Ane Bretschneider Søgaard, Andreas Bøtker Pedersen, Kaja Borup Løvschall, Pere Monge, Josefine Hammer Jakobsen, Leila Džabbarova, Line Friis Nielsen, Sandra Stevanovic, Raoul Walther, Alexander N. Zelikin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Transmembrane signaling is the core adaptation in nature that allows cells to communicate. Here, the authors engineer signaling through the lipid bilayer using chemical, synthetic receptors for their use in the design of artificial cells.

Externí odkaz: https://doaj.org/article/d9661349c54041f0b7cda27311cb5580

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Akademický článek

Chemical zymogens for the protein cysteinome

Autor: Mireia Casanovas Montasell, Pere Monge, Sheiliza Carmali, Livia Mesquita Dias Loiola, Dante Guldbrandsen Andersen, Kaja Borup Løvschall, Ane Bretschneider Søgaard, Maria Merrild Kristensen, Jean Maurice Pütz, Alexander N. Zelikin

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Reversible on/off switches for enzyme activity are foundational in nature but are challenging to design using tools of synthetic chemistry. Here the authors design chemical zymogens amenable for activation via biomolecular interactions.

Externí odkaz: https://doaj.org/article/f86f49355a604cf09148fd650aea7473

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Akademický článek

Synthetic Artificial Apoptosis‐Inducing Receptor for On‐Demand Deactivation of Engineered Cells

Autor: Pere Monge, Kaja Borup Løvschall, Ane Bretschneider Søgaard, Raoul Walther, Thaddeus W. Golbek, Lars Schmüser, Tobias Weidner, Alexander N. Zelikin

Publikováno v: Advanced Science, Vol 8, Iss 13, Pp n/a-n/a (2021)

Abstract The design of a fully synthetic, chemical “apoptosis‐inducing receptor” (AIR) molecule is reported that is anchored into the lipid bilayer of cells, is activated by the incoming biological input, and responds with the release of a seco

Externí odkaz: https://doaj.org/article/62c06663a1c0469096a0338d5d42740e

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Akademický článek

Chemical Artificial Internalizing Receptors for Primary T Cells

Autor: Pere Monge, Anne Tvilum, Ane Bretschneider Søgaard, Kaja Borup Løvschall, Morten T. Jarlstad Olesen, Alexander N. Zelikin

Publikováno v: Advanced Science, Vol 7, Iss 18, Pp n/a-n/a (2020)

Abstract The newest generation of cell‐based technologies relies heavily on methods to communicate to the engineered cells using artificial receptors, specifically to deactivate the cells administered to a patient in the event of adverse effects. H

Externí odkaz: https://doaj.org/article/60838a236f924969a9b1ba8983753d9e

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Akademický článek

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Per‐glycosylation of the Surface‐Accessible Lysines: One‐Pot Aqueous Route to Stabilized Proteins with Native Activity

Autor: Azad Farzadfard, Ole Aalund Mandrup, Pere Monge, Andreas Bøtker Pedersen, Alexander N. Zelikin, Anja Benderoth, Daniel E. Otzen, Kenneth A. Howard, Raoul Walther, Jannik Nedergaard Pedersen

Publikováno v: Walther, R, Monge, P, Pedersen, A, Benderoth, A, Pedersen, J, Farzadfard, A, Mandrup, O, Howard, K, Otzen, D & Zelikin, A N 2021, ' Per-glycosylation of the Surface-Accessible Lysines : One-Pot Aqueous Route to Stabilized Proteins with Native Activity ', ChemBioChem, vol. 22, no. 14, pp. 2478-2485 . https://doi.org/10.1002/cbic.202100228

Chemical glycosylation of proteins is a powerful tool applied widely in biomedicine and biotechnology. However, it is a challenging undertaking and typically relies on recombinant proteins and site-specific conjugations. The scope and utility of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e867abcf5bcb80d38b2f009e217930
https://doi.org/10.1002/cbic.202100228

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Green self-immolative polymer: molecular antenna to collect and propagate the signal for zymogen activation

Autor: Pere Monge, Maria Kristensen, Sheiliza Carmali, Kaja Borup Løvschall, Mireia Montasell, Ane Bretschneider Søgaard, Jean-Maurice Pütz, Livia Loiola, Dante Guldbrandsen Andersen, Alexander N. Zelikin

Chemical zymogens of three different types were established herein around protein cysteinome, in each case converting the protein thiol into a disulfide linkage: zero length Z0, polyethylene glycol based ZPEG, and ZLA that features a fast-depolymeriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc08e4ba088ea582d507301da3e1c244
https://doi.org/10.1101/2021.07.25.453687

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Transmembrane signalling by a bionic receptor: biological input and output, chemical mechanism of signal transduction

Autor: Kaja Borup Løvschall, Raoul Walther, Pere Monge, Sandra Stevanovic, Alexander N. Zelikin, Line D. F. Nielsen

Signal transduction through sealed biological membranes is among the most important evolutionary achievements. Herein, we focus on the development of artificial signal transduction mechanisms and engineer a bionic receptor with capacity of transducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b04989c4005fb2b52362ea11a34d9683
https://doi.org/10.1101/2021.07.25.453684

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Chemical zymogens for the protein cysteinome

Publikováno v: Montasell, M C, Monge, P, Carmali, S, Loiola, L M D, Andersen, D G, Løvschall, K B, Søgaard, A B, Kristensen, M M, Pütz, J M & Zelikin, A N 2022, ' Chemical zymogens for the protein cysteinome ', Nature Communications, vol. 13, 4861 . https://doi.org/10.1038/s41467-022-32609-1
Montasell, M C, Monge, P, Carmali, S, Dias Loiola, L M, Andersen, D G, Løvschall, K B, Søgaard, A B, Kristensen, M M, Pütz, J M & Zelikin, A N 2022, ' Chemical zymogens for the protein cysteinome ', Nature Communications, vol. 13, no. 1, 4861 . https://doi.org/10.1038/s41467-022-32609-1

We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol group was converted into a mixed disulfide: with a small molecule, a non-degradable polymer, or with a fast-depolymerizing fuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4e65646886a13fea642fa1f735dc80
https://pubmed.ncbi.nlm.nih.gov/35982075

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Ceria Nanozyme and Phosphate Prodrugs: Drug Synthesis through Enzyme Mimicry

Autor: Tin H. Huynh, Anne Sofie Fruergaard, Pere Monge, Raoul Walther, Aref Mamakhel, Alexander N. Zelikin

Publikováno v: Walther, R, Huynh, T H, Monge, P, Fruergaard, A S, Mamakhel, A & Zelikin, A N 2021, ' Ceria Nanozyme and Phosphate Prodrugs : Drug Synthesis through Enzyme Mimicry ', ACS Applied Materials and Interfaces, vol. 13, no. 22, pp. 25685-25693 . https://doi.org/10.1021/acsami.1c03890

Nanozymes can mimic the activities of diverse enzymes, and this ability finds applications in analytical sciences and industrial chemistry, as well as in biomedical applications. Among the latter, prodrug conversion mediated by nanozymes is investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fe1eab753bb02cd76c9245fc63f36b
https://pubmed.ncbi.nlm.nih.gov/34033459

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