Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Percy A. Knolle"'
Autor:
Timothy R. McCulloch, Gustavo R. Rossi, Louisa Alim, Pui Yeng Lam, Joshua K. M. Wong, Elaina Coleborn, Snehlata Kumari, Colm Keane, Andrew J. Kueh, Marco J. Herold, Christoph Wilhelm, Percy A. Knolle, Lawrence Kane, Timothy J. Wells, Fernando Souza-Fonseca-Guimaraes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Natural killer (NK) cell function is regulated by a balance of activating and inhibitory signals. Tumor necrosis factor (TNF) is an inflammatory cytokine ubiquitous across homeostasis and disease, yet its role in regulation of NK cells remai
Externí odkaz:
https://doaj.org/article/7d3441596abf4db39ec0dbd7c8ea23d7
Autor:
Judith Sailer, Judith Nagel, Banu Akdogan, Adrian T. Jauch, Jonas Engler, Percy A. Knolle, Hans Zischka
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103256- (2024)
Higher eukaryotes’ life is impossible without copper redox activity and, literally, every breath we take biochemically demonstrates this. However, this dependence comes at a considerable price to ensure target-oriented copper action. Thereto its up
Externí odkaz:
https://doaj.org/article/44dfe9a0989b41839c16b72a5704ed11
Autor:
Valter Bergant, Daniel Schnepf, Niklas de Andrade Krätzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining transcriptomics, proteomics and recombinant viruses we show
Externí odkaz:
https://doaj.org/article/41b117276b3642cfa472a74a5a5f4522
Autor:
Jochen M. Wettengel, Katharina Strehle, Catharina von Lucke, Hedwig Roggendorf, Samuel D. Jeske, Catharina Christa, Otto Zelger, Bernhard Haller, Ulrike Protzer, Percy A. Knolle
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT The continuous genetic evolution of SARS-CoV-2 resulting in the immune escape variant of concern (VoC) Omicron poses a challenge to rapid and accurate diagnosis of infection, especially in high-risk groups such as healthcare workers. We perf
Externí odkaz:
https://doaj.org/article/36323ff370f74fcdaa08b780b173d4ed
Autor:
Knud Esser, Xiaoming Cheng, Jochen M. Wettengel, Julie Lucifora, Lea Hansen-Palmus, Katharina Austen, Armando A. Roca Suarez, Sarah Heintz, Barbara Testoni, Firat Nebioglu, Minh Tu Pham, Shangqing Yang, Alma Zernecke, Dirk Wohlleber, Marc Ringelhan, Mathias Broxtermann, Daniel Hartmann, Norbert Hüser, Julia Mergner, Andreas Pichlmair, Wolfgang E. Thasler, Mathias Heikenwalder, Georg Gasteiger, Andreas Blutke, Axel Walch, Percy A. Knolle, Ralf Bartenschlager, Ulrike Protzer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 2, Pp 201-221 (2023)
Background & Aims: A single hepatitis B virus (HBV) particle is sufficient to establish chronic infection of the liver after intravenous injection, suggesting that the virus targets hepatocytes via a highly efficient transport pathway. We therefore i
Externí odkaz:
https://doaj.org/article/9fd675743fc64b5f93ebf586a31ab2ba
Autor:
Beatrix D.G. Evers, Miriam Hils, Christoph Heuser, Inga M. Hölge, Désirée Argiriu, Yuliya Skabytska, Susanne Kaesler, Christian Posch, Percy A. Knolle, Tilo Biedermann
Publikováno v:
JID Innovations, Vol 3, Iss 4, Pp 100204- (2023)
Innate lymphoid cells (ILCs) are gatekeepers in barrier organs, where they maintain tissue integrity and contribute to host defense as well as tissue repair. Inappropriate activation of ILCs, however, can lead to immunopathology with detrimental resu
Externí odkaz:
https://doaj.org/article/792d8addf4144a979dbd35e52d7b92a6
Autor:
Nina Koerber, Alina Priller, Sarah Yazici, Tanja Bauer, Cho-Chin Cheng, Hrvoje Mijočević, Hannah Wintersteller, Samuel Jeske, Emanuel Vogel, Martin Feuerherd, Kathrin Tinnefeld, Christof Winter, Jürgen Ruland, Markus Gerhard, Bernhard Haller, Catharina Christa, Otto Zelger, Hedwig Roggendorf, Martin Halle, Johanna Erber, Paul Lingor, Oliver Keppler, Dietmar Zehn, Ulrike Protzer, Percy A. Knolle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Waning immunity to SARS-CoV-2 is of concern. Here the authors follow spike- and nucleocapsid specific immunity in convalescent individuals for 9 months observing a decline in antibody levels but persisting T cell response. Vaccination approximately 1
Externí odkaz:
https://doaj.org/article/bbeaccaf4069413988e20f5fcbf34dd9
Autor:
Max Luedemann, Daniela Stadler, Cho-Chin Cheng, Ulrike Protzer, Percy A. Knolle, Sainitin Donakonda
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 799-811 (2022)
Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of SARS-CoV-2 infection and
Externí odkaz:
https://doaj.org/article/c85cd5473077475f9b2b662a5f41b335
Autor:
Ruth Aguilar, Xue Li, Claudia S. Crowell, Teresa Burrell, Marta Vidal, Rocio Rubio, Alfons Jiménez, Pablo Hernández-Luis, Dieter Hofmann, Hrvoje Mijočević, Samuel Jeske, Catharina Christa, Elvira D'Ippolito, Paul Lingor, Percy A. Knolle, Hedwig Roggendorf, Alina Priller, Sarah Yazici, Carlo Carolis, Alfredo Mayor, Patrik Schreiner, Holger Poppert, Henriette Beyer, Sophia E. Schambeck, Luis Izquierdo, Marta Tortajada, Ana Angulo, Erwin Soutschek, Pablo Engel, Alberto Garcia-Basteiro, Dirk H. Busch, Gemma Moncunill, Ulrike Protzer, Carlota Dobaño, Markus Gerhard
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The ability of antibodies to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important correlate of protection. For routine evaluation of protection, however, a simple and cost-efficient anti-SARS-CoV-2 serologi
Externí odkaz:
https://doaj.org/article/a6e424f665b94f03bce0933c83ef8b75
Autor:
Till Bunse, Nina Koerber, Hannah Wintersteller, Jochen Schneider, Alexander Graf, Aleksandar Radonic, Andrea Thuermer, Max von Kleist, Helmut Blum, Christoph D. Spinner, Tanja Bauer, Percy A. Knolle, Ulrike Protzer, Eva C. Schulte
Publikováno v:
Microorganisms, Vol 11, Iss 6, p 1562 (2023)
Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we
Externí odkaz:
https://doaj.org/article/36345614650145adb44c75c6bdcfb444